Rui Xue,Yahong Cai,Guangzhen Bai et al.
Rui Xue et al.
This study investigates the effect of lentivirus-mediated ERO1L silencing on non-small cell lung cancer (NSCLC) cell invasion and migration and explores its underlying molecular mechanisms. RO1L expression was examined in NSCLC tissues. A54...
Capmatinib Counteracts LPS-Induced Pulmonary and Testicular Injury Through Attenuating TLR4/NF-κB, PERK/PI3K, and Caspase-1/GSDMD Signaling Pathways [0.03%]
Capmatinib通过抑制TLR4/NF-κB、PERK/PI3K和Caspase-1/GSDMD信号通路对抗LPS诱导的肺部和睾丸损伤
Esraa G El-Waseif,Sara H Hazem,Dalia H El-Kashef et al.
Esraa G El-Waseif et al.
Lipopolysaccharide (LPS)-mediated systemic inflammatory response accounts for the LPS pathogenicity in multi organs as lung and testis. LPS could cause a dysregulation of host response to infection, which may lead to life-threatening organ ...
Reproductive Toxicities of Anticancer Drugs in Females: A Systematic Review of Mechanisms, Consequences, Clinical Implications, and Oncofertility Care [0.03%]
抗癌药物的生殖毒性：系统性回顾机制、后果、临床意义及肿瘤生殖医学护理
Ahmed Aldarmahi,Ashif Iqubal
Ahmed Aldarmahi
With the advances in molecular diagnostics and newer treatment approaches, the overall survival and quality of life of patients have increased significantly. However, many anticancer drugs often cause ovarian damage or toxicity, leading to ...
Effective Amelioration of Alzheimer's Disease in Preclinical Models With Electrophilic Compounds via Nrf2 Pathway Activation [0.03%]
通过Nrf2通路激活有效改善阿尔茨海默病小鼠模型的病情
Lie Yuan,Muhammad Arif Asghar,Yazhen Zhang et al.
Lie Yuan et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, memory loss, and behavioral changes, with no effective treatments currently available. Oxidative stress has been shown to be associated with AD, bu...
The GLP-1 Receptor Agonist Liraglutide Promotes Anticancer Activities in MCF7 Breast and PC-3 Prostate Cancer Cells by Modulating Glycolysis, Oxidative Stress and Adipokines [0.03%]
GLP-1受体激动剂利拉格列净通过调节糖酵解，氧化应激和脂肪细胞因子在MCF7乳腺癌和PC-3前列腺癌细胞中发挥抗癌作用
Bassem Refaat,Mohamed E Elzubier,Akhmed Aslam et al.
Bassem Refaat et al.
This research explored the anticancer activities of the glucagon-like peptide-1 receptor agonist (GLP1Ra) liraglutide using MCF7 breast and PC-3 prostate cancer cell lines. The study focused on key molecular pathways related to glycolysis a...
Kaempferol Protects Against Hindlimb Ischemia-Reperfusion Injury via Activation of PPARα Signaling [0.03%]
芸香素通过激活PPARα信号对抗后肢缺血再灌注损伤
Yuehe Liu,Muliang Lin,Hong Qian et al.
Yuehe Liu et al.
Limb ischemia-reperfusion (I/R) injury is a life-threatening complication of acute limb ischemia that can result in severe skeletal muscle damage and limb loss, yet effective pharmacological therapies remain limited. Kaempferol (KAE), a nat...
The PVT1/miR-216a-5p/TLR4 Signaling Axis Regulates the Inflammation and Intestinal Epithelial Barrier Function of Ulcerative Colitis [0.03%]
PVT1/miR-216a-5p/TLR4信号轴调节溃疡性结肠炎炎症及肠上皮屏障功能
Meixiao Liu,Zhiguang Xu,Linqi Zhang et al.
Meixiao Liu et al.
Ulcerative colitis (UC) is a chronic, relapsing disease, imposing a heavy disease burden and severely reducing the quality life of patients. This study verified the influence of the PVT1/miR-216a-5p/TLR4 signaling axis on UC. LPS-stimulated...
Diabetes Mellitus Enhances Immune Suppression in Ovarian Cancer via CD155 Upregulation Mediated by the HSP70/P65 Axis [0.03%]
糖尿病通过HSP70 / P65轴介导的CD155上调增强卵巢癌免疫抑制
Lan Han,Yali Zhang,Yan Song et al.
Lan Han et al.
Diabetes mellitus (DM) is increasingly recognized for its role in modifying the tumor microenvironment, but its influence on immune checkpoints in cancer remains underexplored. This study investigates how diabetes-associated conditions infl...
Design of Novel Hybrid Thiourea-Phosphonate Derivatives as Potential Anti-TMV Agents: In Silico Evaluation and (S,O)-Pharmacophoric Site Identification [0.03%]
新型混合噻二唑-膦酸衍生物作为潜在的抗TMV制剂的设计：计算机评估和（S，O）药效团位点识别
Taibi Ben Hadda,Faisal A Almalki,Luai Z Hasoun et al.
Taibi Ben Hadda et al.
In the present study, a series of novel chiral thiourea derivatives incorporating an α-aminophosphonate moiety were designed to target the coat protein (CP) of tobacco mosaic virus (TMV). Their potential anti-TMV activity was further evalu...
Exploring the Role of Wt1/Spon2 Axis in Prostate Cancer Progression and Fibroblast Dynamics [0.03%]
Wt1/Spon2轴在前列腺癌进展和成纤维细胞动态中的作用探讨
Dun Xue,Long Tan,Fengshuai Yang et al.
Dun Xue et al.
The role of the transcription factor Wt1 in prostate cancer (PCa) remains unclear. This study utilized public scRNA-seq datasets and TCGA data to investigate how Wt1 regulates the transition from normal fibroblasts (NFs) to cancer-associate...