Multi-Pathway Renoprotection by Betanin Against Docetaxel Nephrotoxicity: Modulation of Inflammation, ER Stress, Apoptosis, and Ferroptosis [0.03%]
花青素多通路保肾作用对抗多西他赛所致肾毒性：调节炎症、内质网应激、凋亡和铁死亡
Büşra Süzen Celbek,Nurhan Akaras,Hasan Şimşek et al.
Büşra Süzen Celbek et al.
Docetaxel (DTX), a cornerstone chemotherapeutic agent, has its clinical utility significantly limited by dose-dependent nephrotoxicity. This study investigated the multi-pathway renoprotective mechanisms of betanin (BTN), a natural antioxid...
The Relation Between Antibiotic Use and Gastrointestinal Cancer: A Systematic Review and Meta-Analysis [0.03%]
抗生素使用和胃肠道癌症之间的关系：系统回顾和meta分析
Yiwei Wang,Shining Jin,Longfei Xu et al.
Yiwei Wang et al.
Cancer remains a major cause of premature mortality worldwide, with incidence and mortality rates continuing to rise. Antibiotic use, while essential for treating infections, has been linked to an increased risk of certain cancers, particul...
NOTCH3 Modulates Inflammation and Fibrosis in HK2 Cells Under Diabetic Conditions Through TLR4/NF-κB and TGF-β1/Smad3 Signaling [0.03%]
NOTCH3通过TLR4/NF-κB和TGF-β1/Smad3信号调节HK2细胞糖尿病条件下的炎症反应及纤维化
RunHua Tian,ChunXi Zheng
RunHua Tian
To investigate the modulatory role of NOTCH3 in renal inflammatory and fibrotic processes during diabetic nephropathy (DN), focusing on TLR4/NF-κB and TGF-β1/Smad3 signaling pathways. HK2 cells were stimulated with BSA to mimic diabetic c...
Hepatoprotective Potential of Eugenol Against Pesticide Glyphosate-Induced Liver Injury via Nrf2/HO-1 Signaling and Modulation of Apoptosis and Inflammation in Rats [0.03%]
肉桂醇通过Nrf2/HO-1信号和对凋亡及炎症的调节在细胞水平上对抗除草剂Glyphosate引起的肝损伤的肝脏保护潜能研究
Esra Aktas Senocak,Omercan Alat,Ismail Bolat et al.
Esra Aktas Senocak et al.
Glyphosate (GLY) is a widely used herbicide active ingredient applied in agricultural, residential, and public areas. Although the European Chemicals Agency has stated that current evidence is insufficient to classify GLY as an endocrine di...
PGC-1α-Nrf2 Signaling Imbalance Mediates Doxorubicin-Induced Mitochondrial Dysfunction and Cardiac Injury [0.03%]
PGC-1α-Nrf2信号通路平衡失调介导了多柔比星致心肌线粒体功能障碍及损伤
Shaohuan Qian,Yue Guan,Zhuoya Yao et al.
Shaohuan Qian et al.
Doxorubicin (DOX)-induced cardiotoxicity is characterized by mitochondrial dysfunction and oxidative stress; however, the mechanistic interplay between mitochondrial metabolic regulation and antioxidant defense remains unclear. In this stud...
Diethyl Phthalate-Induced Oxidative Stress, Altered Biomarker Responses and Apoptosis in Zebrafish Larvae [0.03%]
邻苯二甲酸二乙酯对斑马鱼幼体诱发的氧化应激、生物标志物变化及凋亡效应
Eswar Marcharla,Sneha Hariharan,Smarika Chauhan et al.
Eswar Marcharla et al.
Diethyl phthalate (DEP) is a widespread and persistent organic pollutant that affects aquatic life and ecosystems. Our study uses zebrafish larvae to assess the effects of DEP on metabolic pathways involved in growth and development. Zebraf...
Tris(2-Chloroethyl) Phosphate (TCEP) Induces Respiratory Toxicity Through Oxidative Stress and Multi-Target Interactions: Evidence From Network Toxicology, Molecular Docking, and Experimental Validation [0.03%]
三(2-氯乙基)磷酸酯通过氧化应激和多靶点相互作用诱导呼吸毒性：来自网络毒理学、分子对接和实验验证的证据
Ruoyu Geng,Fei Ye,Qi Yan et al.
Ruoyu Geng et al.
Tris(2-chloroethyl) phosphate (TCEP) is a ubiquitous organophosphorus flame retardant and an emerging environmental contaminant of concern; however, the specific molecular mechanisms underlying its respiratory toxicity remain poorly underst...
RNF113A Protects Against Sepsis-Induced Myocardial Injury via Activation of the Keap1/Nrf2 Axis to Reduce Ferroptosis [0.03%]
RNF113A通过激活Keap1/Nrf2轴来减少铁死亡从而保护脓毒症诱导的心肌损伤
Linhui Shi,Yiru Weng,Longqiang Ye et al.
Linhui Shi et al.
Sepsis-induced myocardial injury (SIM) is a common complication of sepsis that can cause high morbidity and mortality. However, the molecular mechanisms underlying SIM have still not been fully elucidated. Ferroptosis is a novel form of cel...
Sevoflurane Induces Neurotoxicity and Cognitive Impairment by Up-Regulating Long Non-Coding RNA CEBPA-AS1 [0.03%]
异氟烷通过上调长链非编码RNA CEBPA-AS1诱导神经毒性及认知障碍
Jinpeng Fu,Ya-Wei Yuan,Zhen Ma
Jinpeng Fu
Sevoflurane may induce neurotoxicity and cognitive impairment, though the associated mechanisms remain unclear. This study aimed to investigate how long non-coding RNA CEBPA-AS1 contributed to the neurotoxicity and cognitive impairment indu...
Involvement of ARG2-Mediated Autophagy in Di-2-ethylhexyl Phthalate-Induced Testicular Injury [0.03%]
ARG2介导的自噬在Di-2-乙基己基邻苯二甲酸致睾丸损伤中的作用
Jinpu Peng,Rongyang Zeng,Nini An et al.
Jinpu Peng et al.
Di-2-ethylhexyl phthalate (DEHP) is a common industrial chemical with endocrine-disrupting properties, which is capable of causing developmental abnormalities in the male reproductive system, while the effect of DEHP on testicular cell auto...