Regulation of Glutathione Peroxidases (GPxs) in Breast Cancer: From Mechanisms to Targeted Therapeutics [0.03%]
乳腺癌中谷胱甘肽过氧化物酶（GPXs）的调控：从机制到靶向治疗
Hengyuan Yu,Ju Liao,Ke Zhao
Hengyuan Yu
Breast cancers (BCs) are the most widespread cancer type among females and constitute the second leading cause of cancer fatality. Although there have been some advances in recent years, BC mortality rates remain high, a grim fact that unde...
Therapeutic Effect of Zingerone on Reproductive Damage in Diabetic Male Rats: Potential Role of Sirt1/Nrf2/HO-1 and Bax/Bcl-2 Signaling Pathways [0.03%]
姜辣素对糖尿病雄性大鼠生殖损害的治疗作用及潜在机制研究
Edanur Güler Ekmen,Mehmet Çay,İbrahim Halil Güngör et al.
Edanur Güler Ekmen et al.
Diabetes mellitus exerts a deleterious effect on the male reproductive system, manifesting as a metabolic disease. Recent research has indicated that the ingestion of dietary supplements rich in natural antioxidants may reduce or prevent da...
Environmental Levels of Sodium p-Perfluorous Nonenoxybenzene Sulfonate Induce Nephritis in Renal Proximal Tubular Epithelial Cells via Modulation of Estrogen Signaling Pathways [0.03%]
环境中的钠-p全氟壬氧基苯磺酸通过调节雌激素信号通路诱导肾近曲管上皮细胞肾炎
De Xin Dang,Hui Yang,Shaoyong Xu
De Xin Dang
Sodium p-perfluorous nonenoxybenzene sulfonate (OBS), widely used as an alternative to per- and polyfluoroalkyl substances, has been implicated in toxicity across multiple organ systems. Currently, its effects on renal health remain poorly ...
Metformin Partially Lessens Autism-Related Behaviors in Mice Subjected to Maternal Separation Stress by Combating Hippocampal Neuroinflammation and Oxidative Stress Imbalance [0.03%]
二甲双胍通过对抗海马神经炎症和氧化应激失衡来减轻母体分离压力小鼠的自闭症相关行为
Zahra Vahed Dehkordi,Maryam Ghadiri,Hossein Amini-Khoei
Zahra Vahed Dehkordi
Autism spectrum disorder (ASD) is a neurological condition with growing global prevalence. One of the important factors involved in the pathophysiology of ASD is experiencing stress during early life, such as maternal separation (MS). Metfo...
Niacin Ameliorates EHDPHP-Induced Oxidative Stress and Mitochondrial Dysfunction in H9C2 Cells [0.03%]
烟酸改善EHDPHP诱导的H9C2细胞氧化应激及线粒体功能障碍的作用及其机制研究
Lizhi Dai,Jingxuan Wang,Jia Liu et al.
Lizhi Dai et al.
2-Ethylhexyl diphenyl phosphate (EHDPHP) is a widely used organophosphorus flame retardant frequently detected in environmental matrices and poses potential health risks. However, its cardiotoxic effects on mammalian cardiomyocytes and the ...
LINC00852 Enhances Glycolysis and Tumor Immunity in Pancreatic Cancer via the miR‑494‑3p/GPX8 Axis [0.03%]
长链非编码RNA LINC00852通过miR‑494‑3p/GPX8轴促进胰腺癌糖酵解和肿瘤免疫的作用机制研究
Changyuan Wang,Yi Li,Bole Tian
Changyuan Wang
We aimed to investigate the role and mechanism of LINC00852 in pancreatic cancer (PC), focusing on its regulation of glycolysis and tumor immunity through the miR‑494‑3p/GPX8 pathway. The expression of LINC00852, miR-494-3p, and GPX8 in P...
Mariah Pasternak,Noor Hussein,Veronica Piedra et al.
Mariah Pasternak et al.
A wide variety of cellular functions are performed by vacuoles, including storing nutrients and degrading waste. In cancer cells, some compounds can induce vacuole formation, frequently producing cell death. Interestingly, vacuole-induced d...
Activation of AMPK/SIRT1/PGC-1α Signaling Pathway by Casticin Protects Against S. aureus-Induced Endometritis [0.03%]
蔓荆素通过激活AMPK/SIRT1/PGC-1α信号通路抵抗金黄色葡萄球菌诱发的子宫内膜炎
Nanzhu Wang,Liyu Zhang,Xin Liu et al.
Nanzhu Wang et al.
Endometritis is a prevalent reproductive disorder predominantly triggered by microbial infection. Casticin exhibits diverse pharmacological properties, including anti-inflammatory and anti-tumor activities. However, its protective potential...
Modulation of GSK-3β as Therapeutic Target in Chronic Kidney Disease: Insights From Downstream Molecular Signaling Pathways and Therapeutic Potential of Plant-Derived Phytocompounds [0.03%]
GSK-3β在慢性肾脏病治疗中的作用及机制：来自下游分子信号通路和植物衍生成分的启示
Aftab Alam,Mohammad Usman,Rabea Parveen et al.
Aftab Alam et al.
Renal failure emerges as a more often cause and concern of chronic kidney disease (CKD), throughout the world. Glycogen synthase kinase-3β (GSK-3β) is the most important regulatory protein in CKD. It is a regulator of the main signaling p...