Caffeine in the Context of Sorafenib Chemotherapy: Insights From Experimental Hepatocarcinogenesis [0.03%]
咖啡因在索拉非尼化疗背景下的作用：实验性肝癌发生发展的新见解
Leticia Cardoso Valente,Julia Stocco da Silva,Luana Riechelmann-Casarin et al.
Leticia Cardoso Valente et al.
Hepatocellular carcinoma (HCC) features a high mortality burden worldwide, highlighting the need for improved therapeutic strategies. Caffeine (CAF), a widely consumed bioactive compound, has been reported to exert chemopreventive effects i...
Etomidate Prevents Homocysteine‑Induced Endothelial Dysfunction by Suppressing PERK‑eIF2α‑ATF4 Signaling, Oxidative Stress, Mitochondrial Injury, and Autophagic Dysregulation [0.03%]
依托咪酯通过抑制PERK-eIF2α-ATF4信号传导、氧化应激、线粒体损伤和自噬失调来预防同型半胱氨酸诱导的内皮细胞功能障碍
Mingguan Song,Hongwei Tang
Mingguan Song
Elevated homocysteine (Hcy) is a potent instigator of cerebrovascular endothelial injury, yet effective preventive interventions are scarce. This study identifies the anesthetic etomidate as a protective agent against Hcy-mediated damage in...
Allicin Attenuates Silica-Induced Pulmonary Fibrosis by Targeting the Serpinb2/NF-κB Pathway [0.03%]
大蒜素通过靶向 Serpinb2/ NF- κ B 途径缓解硅致肺纤维化
Zhou Sijing,Wang Jiling,Wu Wenlong et al.
Zhou Sijing et al.
Silica-induced pulmonary fibrosis is a debilitating condition with limited therapeutic options. Allicin, a bioactive compound derived from garlic, has shown potential anti-inflammatory and antifibrotic properties. However, its role in silic...
Neuroprotective Effects of 3,6-Dihydroxyflavone in LPS-Stimulated BV-2 Microglial Cells and an MPTP-Induced Mouse Model of Parkinson's Disease [0.03%]
3,6-二羟基黄酮对LPS激活小胶质BV-2细胞和MPTP诱导的帕金森病模型小鼠的神经保护作用
Arulkumar Kuppamuthu,Divya Chinnappan,Namasivayam Elangovan
Arulkumar Kuppamuthu
Parkinson's disease (PD) is a leading neurodegenerative disorder and is triggered by genetic mutations, environmental toxins, and aging, with limited available treatments. 3, 6-dihydroxyflavone is a flavonoid with antioxidant, anti-apoptoti...
Differential and Combined Therapeutic Effects of Mesenchymal Stem Cells and Glutathione on Methotrexate-Induced Mucositis [0.03%]
间充质干细胞和谷胱甘肽分别及联合治疗甲氨蝶呤诱导的黏膜炎的差异及协同效应研究
Halime Tozak Yıldız,Hilal Akalın,Zeynep Burçin Gönen et al.
Halime Tozak Yıldız et al.
Methotrexate (MTX) is commonly used in chemotherapy but induces severe side effects, such as intestinal mucositis, which is characterized by oxidative stress, inflammation, and epithelial cell death. Mesenchymal stem cells (MSCs) and glutat...
miR-191-5p Is Involved in Polycystic Ovary Syndrome by Targeting SOX4 [0.03%]
微小核糖核酸-miR-191-5p通过靶向SOX4参与多囊卵巢综合征发病机制
Juan Du,Yanni A,Shaomeng Sun et al.
Juan Du et al.
Polycystic ovary syndrome (PCOS) is a common refractory reproductive endocrine disorder in women. It is urgent to identify reliable biomarkers and explore the underlying molecular mechanisms of PCOS pathogenesis. A total of 199 subjects wer...
Zeaxanthin Mitigates Hydroxychloroquine-Induced Retinal Toxicity and Metabolic Reprogramming in ARPE-19 Cells [0.03%]
叶黄素通过缓解羟氯喹诱导的色素上皮细胞代谢重组治疗羟氯喹引起的视网膜毒性
Münire Berna Asal Altıparmak,Emine Merve Yıldırım,Ozan Kaplan et al.
Münire Berna Asal Altıparmak et al.
Long-term usage of the commonly used autoimmune disease drug hydroxychloroquine (HCQ) can result in retinal toxicity due to elevated lysosomal pH, mitochondrial damage, and oxidative stress. Zeaxanthin (ZEA), a carotenoid found mostly in th...
Inhibition of Colorectal Cancer Cell Progression by Picroside II Through Modulation of the Notch1 Signaling Pathway [0.03%]
穿心莲内酯抑制Notch1信号通路诱导结直肠癌细胞周期阻滞和凋亡
Rui Wang,Wei Zhang,Fang Wang et al.
Rui Wang et al.
This study aimed to investigate the biological effects of Picroside II on colorectal cancer (CRC) cells, including its impacts on proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT), and to explore whether its me...
Agmatine Attenuates Methotrexate-Induced Hepatotoxicity: Targeting Oxidative Stress, Inflammation, and Apoptotic Pathways [0.03%]
_agmatine对甲氨蝶呤致肝损伤的保护作用:针对氧化应激、炎症和凋亡通路
Haitham M Sewilam,Dalia H El-Kashef,Hadeer M Abouelezz
Haitham M Sewilam
Drug-induced hepatic insult is the most frequent antecedent of liver dysfunction. The folic acid antagonist, Methotrexate (MTRX), has tremendous applications in the treatment of various tumors, autoimmune disorders, and inflammatory disease...
Selenium Ameliorates Paraquat-Induced Oxidative Stress and Reproductive Damage Through Restoration of Antioxidant Defense in Male Albino Rats [0.03%]
硒通过恢复抗氧化防御来改善百草枯诱导的氧化应激和雄性大鼠生殖损伤
Muhammad Razzaq Shahid,Muhammad Shahid Mehmood,Sajid Hussain et al.
Muhammad Razzaq Shahid et al.
Paraquat (PQ), a widely used non-selective herbicide, poses serious environmental and health risks due to its strong oxidative potential. Although its toxic impacts on the liver, kidneys, and lungs are well documented, limited information e...