Deciphering the Formulation-Dependent Neurotoxicity of Irinotecan: An Integrated Pharmacovigilance and Mechanistic Study [0.03%]
解读伊立替康致神经毒性的剂型依赖性：基于药物警戒和机制研究的综合分析
Cheng Shen,Wei Ma,Jing Lu et al.
Cheng Shen et al.
Irinotecan is a key chemotherapeutic agent, but its neurotoxicity limits its utility. Observed differences in neurotoxicity between conventional and liposomal formulations are poorly characterized mechanistically. This study aimed to system...
Atorvastatin Reduces Alcohol-Related Cardiac and Liver Tissue Damage, Oxidative Stress, Inflammation, Apoptosis, and Thiol-Disulfide Imbalance in Rats [0.03%]
阿托伐他汀减轻酒精引起的心脏和肝脏组织损伤、氧化应激、炎症、凋亡及硫氧还蛋白不平衡作用机制研究(英文)
Cumaali Demirtas,Şahhan Kılıç,Mert Babaoğlu et al.
Cumaali Demirtas et al.
Excessive alcohol consumption causes significant cardio-hepatic damage. This study investigated the effects of standard (10 mg/kg) and high (40 mg/kg) doses of atorvastatin on fibrosis, hypertrophy, apoptosis, inflammation, oxidative stress...
Glucosamine Promotes Autophagy and Attenuates Hepatic Steatosis Via O-GlcNAcylation-Mediated Mechanisms [0.03%]
葡萄糖胺通过O-GlcNAc修饰介导的机制促进自噬并减轻肝脂肪变性
Jiwon Park,Dong Yeol Kim,Quynh T N Nguyen et al.
Jiwon Park et al.
Autophagy is a key cellular process regulating lipid turnover and maintaining hepatic homeostasis, and its impairment is closely associated with the pathogenesis of nonalcoholic fatty liver disease (NAFLD). In this study, we examined the ef...
Zingerone Alleviates Acetaminophen-Induced Liver Damage by Regulating Oxidative Stress, Inflammation, Apoptosis, Endoplasmic Reticulum Stress, and Autophagy [0.03%]
姜辣素通过调节氧化应激、炎症、凋亡、内质网应力和自噬来缓解对乙酰氨基酚致肝损伤
Serpil Aygörmez,Mustafa Makav,Sevda Eliş Yıldız et al.
Serpil Aygörmez et al.
The aim of this study is to investigate the protective effect of zingerone (ZNG), an antioxidant agent, against acetaminophen (APAP)-induced liver damage, which is used as an analgesic and antipyretic. For this purpose, twenty-eight male ra...
SRM 1650b Administration to Isolated Rat Heart Aggravates Ischemia-Reperfusion Injury via Mitochondrial Dysfunction and Downregulation of PI3K/Akt Signaling Pathways [0.03%]
SRM1650B通过线粒体功能障碍和PI3K/Akt信号通路下调加剧孤立大鼠心脏缺血再灌注损伤
Kirankumar Balu,Uvasshri Vijayakumar,Bhavana Sivakumar et al.
Kirankumar Balu et al.
Numerous studies have demonstrated an association between diesel particulate matter (DPM) exposure and cardiotoxicity; recent evidence further suggests that cardiomyocytes may directly internalize DPM. In the present study, we investigated ...
Serine Ameliorates Cadmium-Induced Testicular Injury by Regulating the PGAM1/PHGDH Signaling Pathway [0.03%]
丝氨酸通过调节PGAM1/PHGDH信号通路缓解镉诱导的睾丸损伤
Xueru Wang,Na Luo,Yonggang Ma et al.
Xueru Wang et al.
Cadmium (Cd) is a widespread environmental contaminant that impairs male reproductive function; however, the metabolic mechanisms underlying Cd-induced testicular toxicity remain incompletely understood. This study investigated whether seri...
Extracellular Vesicles in Acute Myeloid Leukemia: Opportunities and Obstacles for Therapeutic Advancement [0.03%]
急性髓系白血病中外泌体的机会与挑战：治疗进展中的机遇与障碍
Rongrong Hu,Zaker Ataullev,Luping Lou
Rongrong Hu
Acute myeloid leukemia (AML) is a disease characterized by uncontrolled proliferation and blocked maturation of hematopoietic stem and progenitor cells. Despite progress in its clinical management, many patients continue to relapse or show ...
Ameliorative Effects of Silymarin on Ovarian Ischemia/Reperfusion Injury via Modulation of Oxidative Stress and Inflammatory Pathways [0.03%]
奶蓟素通过调节氧化应激和炎症通路改善卵巢缺血再灌注损伤的积极作用
Saime Ozbek Sebin,Basak Gulakar,Ayhan Tanyeli et al.
Saime Ozbek Sebin et al.
Ischemia/reperfusion (IR) injury secondary to ovarian torsion results in oxidative stress, inflammation, and structural damage to the ovary. Silymarin (SLY), a natural flavonoid complex, possesses potent antioxidant and anti-inflammatory ef...
Silymarin Modulates 3-Nitropropionic Acid-Induced Oxidative Neurotoxicity and Apoptosis Through the Inhibition of TRPV1 Channel in Mouse Brain and Hippocampal Neurons [0.03%]
乳蓟素通过抑制瞬时受体电位香草酸亚型1通道调节3-硝基丙酸诱导的氧化神经毒性及凋亡：基于小鼠脑组织和海马神经元的研究
Abdulsamed Kükürt,Ömer Faruk Başer
Abdulsamed Kükürt
The stimulation of the TRPV1 channel through capsaicin (CAP) and oxidative stress induces increases of 3-Nitropropionic acid (3NPA)-induced brain and hippocampus injury, whereas its inhibition by antioxidant silymarin (SIL) and capsazepine ...
Mitochondrial Dysfunction in Ulcerative Colitis: Pathogenic Mechanisms and Novel Therapeutics [0.03%]
溃疡性结肠炎中的线粒体功能障碍：发病机制与新型疗法
Hongyan Ran,Siyuan Zhou,Hui Zou et al.
Hongyan Ran et al.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease driven by a complex interplay of mitochondrial dysfunction. These defects impair energy production, increases oxidative stress, and disrupts immune balance. Here we review thre...