Integrated Molecular Docking and Gene Expression Analyses Suggest a Potential Interaction Between Diphtheria Toxin and Bcl-2 in HT-29 Colorectal Cancer Cells [0.03%]
基于分子对接及基因表达分析的白喉毒素与Bcl-2潜在相互作用的研究
Elif Ercan,Tugba Yalcinkaya,Belkis Levent et al.
Elif Ercan et al.
Diphtheria toxin (DT) has been reported to exhibit cytotoxic effects in several cancer models; however, the molecular mechanisms underlying its apoptotic activity remain incompletely understood. In our previous study, DT was shown to induce...
Ferulic Acid Suppresses Diabetes-Induced Atherosclerosis by Targeting Oxidative Stress, NF-κB p65/iNOS, and miRNAs Pathways [0.03%]
大黄素通过针对氧化应激、NF-κB p65/iNOS和miRNAs途径抑制糖尿病诱导的动脉粥样硬化
Taqwa A Abdelhamed,Ahmed A G El-Shahawy,Fatma I Abo El-Ela et al.
Taqwa A Abdelhamed et al.
Atherosclerosis, a major complication of diabetes mellitus, involves complex metabolic and inflammatory disruptions that remain inadequately addressed by current therapies. Ferulic acid (FA), a plant-derived polyphenol, possesses antioxidan...
Mitigation of Cisplatin-Induced Neurotoxicity via Nrf2/HO-1 Signaling and Autophagy: The Protective Role of Vitamin D [0.03%]
维生素D通过Nrf2/HO-1信号传导和自噬减轻顺铂引起的神经毒性：维生素D的保护作用
Songul Cuglan,Azibe Yildiz,Kevser Tanbek
Songul Cuglan
This study examined the impact of vitamin D (Vit D) treatment on oxidative stress in the brain caused by cisplatin (CP). A total of 21 Wistar Albino rats were allocated into three groups: control; CP, which received a single dose of 7 mg/kg...
Co-Exposure of N-Methyl-N-Nitrosourea and Benzo[A]Pyrene Elicits Toxicity in Drosophila Melanogaster [0.03%]
N-甲基-N-亚硝脲和苯并[a]芘共暴露引起果蝇毒性反应
Judith Chizoba Madu,Amos Olalekan Abolaji,Oluwatosin Adekunle Adaramoye
Judith Chizoba Madu
Human exposure to environmental pollutants is multi-variant with resultant interactive effects such as oxidative stress, and it's associated with several disease pathogenesis. This study aimed to assess the effects on behavioural pattern, r...
Silymarin Attenuates Arsenic-Induced Mitochondrial Dysfunction and Suppression of Nrf2/ARE-Regulated Phase II Detoxification Genes in Rat Brain [0.03%]
奶蓟素改善砷诱导的脑线粒体功能障碍及Nrf2/ARE调节的Ⅱ相解毒基因抑制作用
Annu Verma,Manoj Soni,Karuna Nandal et al.
Annu Verma et al.
Arsenic, an environmentally widespread and highly poisonous metalloid, presents major risks to health by interfering with cellular mechanisms and compromising mitochondrial performance. This research evaluated the mitigating effects of sily...
Construction of a Breast Cancer Predictive Nomogram Based on Diverse Cell Death Methods and Reveal Tumor Microenvironment Characterization [0.03%]
基于多种细胞死亡方法的乳腺癌预测 nomogram 的构建及肿瘤微环境特征解析
Rihan Wu,Zirui Wang,Yuanrui Bai et al.
Rihan Wu et al.
This study aimed to develop a robust predictive model and nomogram for breast cancer (BC) based on genes associated with diverse cell death methods. A prognostic model was constructed using the LASSO Cox method, incorporating twelve genes (...
Protective Role of Apigenin-PEGylated Chitosan Nanoparticles Against Pesticide Deltamethrin-Induced Liver Injury via Antioxidant Activation, NF-κB Inhibition, and Bcl-2/Bax/Caspase-3 Signaling Modulation [0.03%]
芹菜素-聚乙二醇修饰的壳聚糖纳米颗粒通过抗氧化激活、NF-κB抑制和Bcl-2/Bax/Caspase-3信号调节对抗杀虫剂氯氟氰菊酯引起的肝损伤的作用研究
Ekramy M Elmorsy,Ahmad Najem Alshammari,Mohammed Saleh Alfawaz et al.
Ekramy M Elmorsy et al.
The present investigation evaluated the liver-protective effect of apigenin encapsulated in PEGylated chitosan nanoparticles (APG-PCHNPs) against hepatotoxicity induced by pesticide deltamethrin (DLM) in rats. Sixty rats were randomly alloc...
Occupational Exposure to Chemical Solvents and Heavy Metals and Oxidative Stress-Related Sperm Dysfunction in Textile Workers [0.03%]
职业接触化学溶剂和重金属对纺织工人氧化应激相关精子功能障碍的影响
P Madhan Kumar,R Parameswari,R Babujanarthanam
P Madhan Kumar
Occupational exposure to chemical solvents and heavy metals among workers in textile-related industries has emerged as a significant risk factor for male reproductive dysfunction; however, the underlying biological mechanisms remain incompl...
Acrylamide Exposure Activates EGFR-PI3K in Intestinal Macrophages to Promote the Onset and Progression of Inflammatory Bowel Disease [0.03%]
丙烯酰胺通过激活肠道巨噬细胞中的EGFR-PI3K信号通路促进炎症性肠病的发生发展
Zhangchi Sun,Luodan Wang
Zhangchi Sun
To investigate the impact and mechanisms of acrylamide (AA), an environmental pollutant, on inflammatory bowel disease (IBD). We exposed normal mice and chronic colitis mouse models to AA and examined the pathological changes in intestinal ...