Goniothalamin as a Styryl-Lactone Toxicophore in Cancer Models: Electrophile-Driven DNA Damage, Reactive Oxygen Species-Endoplasmic Reticulum Stress Signaling and Detoxification-Relevant Safety Considerations [0.03%]
goniothalamin作为抗癌模型中的肉桂酰乳酸毒物：路易斯碱驱动的DNA损伤、活性氧-内质网应激信号和解毒相关的安全性考虑因素
Nataša Joković,Strahinja Pešić,Marija Novaković et al.
Nataša Joković et al.
Goniothalamin (GTN), a natural styryl-lactone from the Goniothalamus genus, has demonstrated cytotoxic properties against a variety of human cancer cell lines with minimal effects on normal cells. Its traditional medicinal use and prelimina...
Protective Potential of Vinpocetine on Acrylamide Induced Liver Toxicity in Male Albino Rats [0.03%]
长春花碱对雄性 albino 大鼠丙烯酰胺致肝损伤的保护作用研究
Eman M S Shaheen,Marwa A E Abd El-Maksoud
Eman M S Shaheen
Acrylamide is a highly reactive carbonyl compound extensively utilized in industrial applications. It shows a significant association with oxidative stress, neurotoxic, and genotoxic effects. This study sought to assess the protective effec...
Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic-Therapeutic Directions of Cardiovascular Diseases [0.03%]
心肌脂代谢紊乱：心血管疾病病理核心及新的诊疗思路
Peiyun Xie,Qun Zeng,Hongrui Wang et al.
Peiyun Xie et al.
Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation (FAO) supplying the majority of ATP in the healthy adult heart. This review synthesizes the core regulatory network governing cardiac lipid ...
Phenylsulfonylethyl-Substituted Benzimidazolium Salts: Synthesis, Characterization, Crystal Structure, Molecular Docking, and Inhibitory Properties Against Various Enzymes [0.03%]
苯磺酰乙基取代的苯并咪唑𬭩盐：合成、表征、晶体结构、分子对接及其对各种酶的抑制性能研究
Yetkin Gök,Ali Kazancı,Yeliz Demir et al.
Yetkin Gök et al.
N-heterocyclic carbenes (NHCs) are chemical structures called heterocyclic structures that contain one or more nitrogen atoms. N-heterocyclic compounds are the basic building blocks of many drugs and biologically active molecules. One of th...
MiR-138-5p Suppresses Glucose Metabolism to Inhibit the Progression of Nasopharyngeal Carcinoma by Targeting the CENPN/PI3K/Akt/mTOR Signaling [0.03%]
miR-138-5p通过靶向CENPN/PI3K/Akt/mTOR信号通路抑制葡萄糖代谢以阻断鼻咽癌进展
Hongxia Guan,Yang Jiang,Hui Li
Hongxia Guan
Nasopharyngeal cancer (NPC) is a malignant tumor that originates from mucosal epithelial cells of the nasopharynx. As an emerging cancer-associated microRNA, miR-138-5p has been shown to modulate various malignant cell malignancies. However...
m6A-methylated circFANCB Promotes Gastric Cancer Progression by Regulating Cellular Ferroptosis Through miR-454-3p/CEACAM5 [0.03%]
circFANCB通过miR-454-3p/CEACAM5轴调节细胞铁死亡促进胃癌发生发展中的m6A甲基化作用
Haifeng Wang,Yan Li,Tiantian Sun et al.
Haifeng Wang et al.
Gastric cancer (GC) is a major global digestive malignancy with high incidence and mortality. Circular fanconi anemia complementation group B (circFANCB) expression is elevated in cancer, and its suppression suppresses tumor progression. Ho...
Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance [0.03%]
从代谢物到修饰因子：乳酰化在结直肠癌发生及耐药中的关键作用
Shuilan Yao,Yun Liang,Xinwen Liang et al.
Shuilan Yao et al.
Colorectal cancer (CRC) is a highly lethal malignancy worldwide. Lactylation, which serves as a key metabolic-epigenetic bridge driving malignant progression, is involved in CRC development, metastasis, immunosuppression, and drug resistanc...
Investigation of the Efficacy of Orientin in Streptozotocin-Induced Type 1 Diabetes Model and Pancreatic Beta-TC6 Cells [0.03%]
评估金丝桃素对链脲佐菌素诱导的I型糖尿病模型及胰岛β-TC6细胞疗效的研究
Bengul Ozdemir Sarikaya,Seyit Ali Bingol
Bengul Ozdemir Sarikaya
Diabetes mellitus is a major endocrine disorder with rapidly increasing global prevalence and numerous systemic complications. Orientin, a flavonoid isolated from various medicinal plants, is known for its potent antioxidant and anti-inflam...
PERK Signaling Pathway Mediates the Hepatoprotective Effects of Naringenin Against Cadmium-Induced Liver Injury in Rats [0.03%]
芸香素通过PERK信号通路介导大鼠肝脏镉毒性防护作用
Chengxiang Guo,Hao Ling,Mengmeng Gao et al.
Chengxiang Guo et al.
Cadmium (Cd), a heavy metal element with extensive industrial applications, exhibits significant toxicological risks in biological systems (Zhu et al. 2019). Naringenin (Nar), a bioactive flavonoid possessing potent antioxidant properties, ...
Nano-Rosmarinic Acid Protects Against Chlorfenapyr-Induced Testicular Toxicity Through Modulation of NRF2/HO-1 and NF-κB/NLRP3 Signaling Pathways [0.03%]
纳米石竹酸通过调节NRF2 / HO-1和NF-κB / NLRP3信号通路抵抗氯苯醚菊酯诱导的睾丸毒性
Ahmad Najem Alshammari,Ayat B Al-Ghafari,Huda A Al Doghaither et al.
Ahmad Najem Alshammari et al.
Chlorfenapyr (CFP) is a widely used pesticide associated with significant toxicological effects, including reproductive toxicity. Rosmarinic acid (RA) possesses potent antioxidant and anti-inflammatory properties; however, its therapeutic a...