Inhibiting CSNK2A Suppresses the Viability, Autophagy, Growth and Motility of Ectopic Endometrial Stromal Cells [0.03%]
抑制CSNK2A可抑制异位子宫内膜成纤维细胞的活力、自噬、生长和运动能力
Ming Li,Meiling Sun,Junying Liu et al.
Ming Li et al.
Endometriosis is an estrogen-dependent disorder characterized by ectopic growth of endometrial tissue. There is a lack of effective biomarkers for early detection and revealing mechanisms of endometriosis. CSNK2A1 is a compositionally activ...
Quercetin and Nephrotoxicity: A Narrative Review of Cellular Pathways and Therapeutic Possibilities [0.03%]
檞皮素与肾毒性：细胞途径和治疗可能性的叙述性回顾
Zahra Yazdanpanah,Hossein Sobhani,Mahboobeh Navabi et al.
Zahra Yazdanpanah et al.
Nephrotoxicity is a major clinical challenge, often triggered by chemotherapeutic agents, environmental toxins, and metabolic imbalances. Its underlying mechanisms-oxidative stress, inflammation, mitochondrial dysfunction, and apoptosis-can...
Astragaloside IV Ameliorates Acetaminophen-Induced Liver Injury via Targeting the PCK1/PPARG/RXRA-Mediated PPAR Signaling Pathway [0.03%]
ASTRAGALOSIDE Ⅳ通过靶向PCK1/PPARG/RXRA介导的PPAR信号通路改善乙酰氨基酚致肝损伤
Shunlei Jiang,Xia Ren,Xin Gao et al.
Shunlei Jiang et al.
Acetaminophen (APAP) overdose can induce hepatic injury and even acute liver failure. Astragaloside IV (AS-IV), a saponin isolated from Astragalus membranaceus, demonstrates protective effects on both digestive and immune systems owing to i...
Design, Synthesis, and Biological Evaluation of Novel Quinazoline-Thiazole Hybrids As Potential Anticancer Agents [0.03%]
新型喹唑啉-噻唑杂化物作为潜在抗肿瘤药物的设计、合成及生物活性评估
Sobhi M Gomha,Sami A Al-Hussain,Basant Farag et al.
Sobhi M Gomha et al.
A convenient synthetic route was developed for the preparation of structurally diverse quinazolinone-thiazole hybrids using a common thiosemicarbazide intermediate (2), which underwent cyclization with different electrophiles to afford thre...
Ellagic Acid Protects Multiple Organ Injury Induced by Cyclophosphamide-Mediated Oxidative Stress: Biochemical and Histological Insights [0.03%]
ellagic酸通过生化和组织学视角保护环磷酰胺介导的氧化应激所致多器官损伤
Asim Amitabh Sahu,Satendra Kumar Nirala,Monika Bhadauria
Asim Amitabh Sahu
Cyclophosphamide, a commonly used alkylating chemotherapeutic, induces acute multiple organ injury through oxidative stress, inflammation, and redox imbalance. The present study identifies oxidative signalling as a key mechanism of cyclopho...
ALOX15-Mediated 15-HETE Uptake Drives Lung Cancer Cells Ferroptosis and Enhances CD8+ T Cell Immunity in Lung Cancer [0.03%]
ALOX15介导的15-HETE摄取驱动肺癌细胞铁死亡并增强肺部免疫监视中的CD8+T细胞活性
Jianglong Wang,Gangyi Tang,Lin Zhang
Jianglong Wang
ALOX15 exerts tumor suppressor in numerous cancers. However, the role of ALOX15 in lung cancer is scarcely reported. This study aimed to investigate the role of ALOX15 in lung cancer. GSE225620 was used to analyzed the differentially expres...
Lutein Influences Cisplatin Sensitivity Through Differential Regulation of DNA Damage Response Genes in Breast Cancer Cells [0.03%]
叶黄素通过差异化调控DNA损伤反应基因影响乳腺癌细胞对顺铂的敏感性
Funda Demirtas Korkmaz,Zekeriya Duzgun,Aysegul Cebi
Funda Demirtas Korkmaz
This study investigated the effects of lutein, a natural carotenoid, and the chemotherapeutic agent cisplatin on three cell lines: HUVEC (non-cancerous), MDA-MB-231 (ER- breast cancer), and MCF-7 (ER+ breast cancer). Cells were treated with...
Tocilizumab and Dexamethasone Reduce TNF-α and IL-33 and Oxidative Stress in Kidney Tissue in Oleic Acid-Induced ARDS Model [0.03%]
托珠单抗和地塞米松可减少脂质氧化损伤性ARDS小鼠模型肾组织中TNF-α、IL-33及氧化应激损伤
Huseyin Serkan Erol,Beste Demirci,Mohammad Alhilal et al.
Huseyin Serkan Erol et al.
The most common extrapulmonary organ injury in cases of acute respiratory distress syndrome (ARDS) is acute kidney injury (AKI). This study was designed to investigate the effects of tocilizumab and dexamethasone on antioxidant and proinfla...
A Biphasic Mitochondrial Damage-Management System: The Mitochondrial Derived Vescicles as Yin and Yang [0.03%]
阴阳双相的线粒体损伤控制系统：线粒体衍生囊泡作为阴阳双方
Salvatore Nesci
Salvatore Nesci