The hepatoprotective potential of tannic acid against doxorubicin-induced hepatotoxicity: Insights into its antioxidative, anti-inflammatory, and antiapoptotic mechanisms [0.03%]
单宁酸对阿霉素致肝损伤的保护潜力：其抗氧化，抗炎和抗凋亡机制的见解
Neslihan Özturk,Hamid Ceylan,Yeliz Demir
Neslihan Özturk
Doxorubicin (DOX), which is frequently used in cancer treatment, has limited clinical use due to adverse effects on healthy tissues, especially the liver. Therefore, it is necessary to research the molecular basis of DOX-induced organ and t...
Investigating the anticancer properties of six benzothiazolopyrimidine derivatives on colon carcinoma cells, in vitro and in vivo [0.03%]
体内外结直肠癌细胞中六种苯并噻唑嘧啶衍生物的抗肿瘤性质研究
Melika Bakharzi,Elham Attar,Hossein Garmabi et al.
Melika Bakharzi et al.
Colorectal cancer (CRC) is the third most common cancer in the world. Despite considerable improvements in the treatment of this cancer, further research to discover novel and more effective agents is ongoing. In this study, possible cytoto...
Toxicological effects of Honokiol on zebrafish and its underlying mechanism [0.03%]
Honokiol的毒理效应及其作用机制研究
Jue Lin,Hongli Liu,Xiaoli Huang et al.
Jue Lin et al.
The compound Honokiol, derived from the bark of Magnolia officinalis, possesses the ability to induce apoptosis and inhibit cellular damage caused by reactive oxygen species. The objective of this study was to investigate the toxicological ...
Protective effect of rutin on acrylamide induced ovarian inflammation, oxidative stress, DNA damage, and hormonal changes: Based on in silico and in vivo study [0.03%]
槲皮素对丙烯酰胺诱导的卵巢炎症、氧化应激、DNA损伤和激素变化的保护作用：基于计算机模拟和体内研究
Divya Gupta,Sadhana Shrivastava,Subodh Kumar et al.
Divya Gupta et al.
Acrylamide (AA) is a carcinogenic compound that affects people due to its frequent use in laboratories and industry as well as the high-temperature cooking of foods with high hydrocarbon content. AA is known to cause severe reproductive abn...
Sitagliptin synergizes 5-fluorouracil efficacy in colon cancer cells through MDR1-mediated flux impairment and down regulation of NFκB2 and p-AKT survival proteins [0.03%]
西他列汀通过多药耐药蛋白1介导的代谢流下降和NFκB2及p-AKT促生存蛋白质下调增强结直肠癌细胞中氟尿嘧啶的作用
Asmaa Eisa,Shaden M Hanafy,Hany Khalil et al.
Asmaa Eisa et al.
5-fluorouracil (5-FU) is an inexpensive treatment for colon cancer; however, its efficacy is limited by chemoresistance. This study investigates the combination therapy approach of 5-FU with Sitagliptin (Sita), a diabetic drug with potentia...
Hepatoprotective effect of astaxanthin against cholestasis liver fibrosis induced by bile duct ligation in adult Wistar rats [0.03%]
虾青素对胆管结扎诱导的成年Wistar大鼠肝纤维化的肝保护作用
Azadeh Laderian,Maedeh Ghasemi,Pejman Mortazavi et al.
Azadeh Laderian et al.
In this study, we evaluated the hepatoprotective effects of astaxanthin, a natural carotenoid, against the cholestatic liver fibrosis induced by bile duct ligation (BDL). Toward this end, male rats were subjected to BDL and treated with ast...
Effect of ferroptosis inhibitors in a murine model of acetaminophen-induced liver injury [0.03%]
ferroptosis抑制剂在对乙酰氨基酚致小鼠肝损伤中的作用研究
Olamide B Adelusi,Yasaman Etemadi,Jephte Y Akakpo et al.
Olamide B Adelusi et al.
Liver injury caused by acetaminophen (APAP) overdose is the leading cause of acute liver failure in western countries. The mode of APAP-induced cell death has been controversially discussed with ferroptosis emerging as a more recent hypothe...
Ezetimibe ketone protects against renal ischemia-reperfusion injury and attenuates oxidative stress via activation of the Nrf2/HO-1 signaling pathway [0.03%]
依折麦布酮通过激活Nrf2/HO-1信号通路对抗肾缺血再灌注损伤及氧化应激
Zhen Chen,Kai Wang,Xiaozhou He et al.
Zhen Chen et al.
Recently, ezetimibe (EZM) has been suggested to be a potent Nrf2 activator that is important for preventing oxidative stress. Interestingly, we found that its metabolite ezetimibe ketone (EZM-K) also has antioxidant effects. Thus, we invest...
VALD-2 mitigates cisplatin-induced acute kidney injury: Mechanistic insights into oxidative stress modulation and inflammation suppression [0.03%]
VALD-2缓解顺铂所致急性肾损伤：抗氧化应激和抗炎作用机制研究
Xuhui Zhao,Yuna Meng,Chunyan Dang et al.
Xuhui Zhao et al.
This study explores the compelling antitumor properties of VALD-2, a synthetic Schiff base ligand known for its low toxicity. The focus is on investigating VALD-2's protective role against cisplatin-induced acute kidney injury (AKI) in mice...
Synthesis of chitosan polyethylene glycol antibody complex for delivery of Imatinib in lung cancer cell lines [0.03%]
用于肺癌细胞系的伊马替尼输送的壳聚糖-聚乙二醇抗体复合物的合成
Mehrdad Kamali,Hanieh Jafari,Fatemeh Taati et al.
Mehrdad Kamali et al.
Lung cancer is known as the most common cancer. Although the Ramucirumab antibody is a second-line treatment for lung cancer, the high interstitial fluid pressure limits the antibody's performance. In this way, Imatinib is a chemotherapeuti...