WNT1/ROR2 pathway enhances the Triple-Negative breast cancer invasion, migration, and Epithelial-Mesenchymal transition [0.03%]
WNT1/ROR2信号通路增强三阴性乳腺癌的侵袭、迁移和上皮间质转化能力
Xin Jin,Chunlan Fu,Yusa Chen et al.
Xin Jin et al.
It has been evidenced that ROR2 influences the growth of many tumors, including non-small cell lung cancer, osteosarcoma, and breast cancer. This research examined the effect of the WNT1/ROR2 signaling pathway on the progression of triple-n...
Multimodal action of phosphodiesterase 5 inhibitors against neurodegenerative disorders: An update review [0.03%]
磷酸二酯酶5抑制剂在神经退行性疾病中多模式作用的更新研究综述
Niraj Kumar Singh,Pranjul Singh,Prachi Varshney et al.
Niraj Kumar Singh et al.
Phosphodiesterase type 5 (PDE5) is an enzyme primarily found in the smooth muscle of the corpus cavernosum and also highly expressed in the substantia nigra, cerebellum, caudate, hippocampal regions and cerebellar purkinje cells, responsibl...
HIF1A/PCDH7 axis mediates fatty acid synthesis and metabolism to inhibit lung adenocarcinoma anoikis [0.03%]
HIF1A/PCDH7轴介导脂肪酸合成和代谢以抑制肺腺癌脱离诱导的细胞死亡
Xiaoyan Yang,Qingfeng Zhang,Liyang Wei et al.
Xiaoyan Yang et al.
Background: Aberrantly expressed PCDH7 participates in the malignant progression of many cancers. PCDH7 has been newly discovered as a risk factor in lung cancer, but its functional study in lung adenocarcinoma (LUAD) has...
A novel quinazoline derivative exhibits potent anticancer cytotoxicity via apoptosis and inhibition of angiogenesis in DMBA-induced mammary gland carcinoma [0.03%]
一种新型喹唑啉衍生物通过诱导细胞凋亡和抑制血管生成发挥高效的抗乳腺癌毒性作用
Soniya Rani,Rimjhim Trivedi,Mohd Nazam Ansari et al.
Soniya Rani et al.
Mammary gland carcinoma is one of the most prevalent and deadly diseases among women globally. It is a type of solid malignant tumor. In this malignant tumor, the microenvironment becomes hypoxic in rapidly proliferating cancer cells. These...
SIRT2 deacetylates and decreases the expression of FOXM1 in colon cancer [0.03%]
SIRT2通过去乙酰化抑制FOXM1表达进而抑制结肠癌细胞的生长和转移
Baris Yildiz,Ramazan Demirel,Jonas J Staudacher et al.
Baris Yildiz et al.
New FOXM1-specific inhibitors with the potential to be used for therapeutic purposes are under extensive research. We hypothesized that deacetylation of FOXM1 would decrease protein expression, thus providing novel therapeutic management of...
Daidzein ameliorates experimental traumatic brain injury-induced neurological symptoms by suppressing oxidative stress and apoptosis [0.03%]
黄豆苷元通过抑制氧化应激和凋亡改善实验性创伤性脑损伤所致的神经症状
Tehreem Haider,Salman Khan,Tehmina Bibi et al.
Tehreem Haider et al.
Traumatic brain injury (TBI) causes deficits in neurological function, induces pathological changes, and increases oxidative stress. The current investigation aimed to determine Daidzein's neuroprotective potential in experimental TBI. Init...
miR-195-5p inhibits cisplatin resistance in lung adenocarcinoma by regulating DNA damage via targeting E2F7 [0.03%]
miR-195-5p通过靶向E2F7调节DNA损伤来抑制顺铂耐药在肺腺癌中的作用
Huanghui Wu,Biaolong Zheng
Huanghui Wu
Lung adenocarcinoma (LUAD) emerges as one of the most lethal malignant tumors worldwide. Platinum-based combination chemotherapy remains one of the main methods for patients with advanced LUAD. Due to the resistance, the effect of this chem...
The mechanistic pathway induced by fenpropathrin toxicity: Oxidative stress, signaling pathway, and mitochondrial damage [0.03%]
fenpropathrin中毒诱导的机制路径：氧化应激、信号转导和线粒体损伤
Maher M Soliman,Adel F Tohamy,Abdelbary M Prince et al.
Maher M Soliman et al.
Fenpropathrin (FNP) is a kind of insecticide and acaricide known as pyrethroid. It is very effective, has a wide range of activities, and works quickly. Internationally, it is commonly considered the most powerful pyrethroid insecticide. Ne...
Vanillic acid ameliorates diethyl phthalate and bisphenol S-induced oxidative stress and neuroinflammation in the hippocampus of experimental rats [0.03%]
香草酸改善DEP和BPS诱导的实验大鼠海马区氧化应激及神经炎症作用研究
Ofem Effiom Eteng,Emmanuel Ifeanyichukwu Ugwor,Adewale Segun James et al.
Ofem Effiom Eteng et al.
Long-term adverse effects on human health are caused by exogenous compounds that alter the functions of biological systems, especially neuroendocrine disruptors like diethyl phthalate (DEP) and bisphenol S (BPS). Although vanillic acid (VA)...
Experimental colitis is comorbid with social interaction deficits and anxiety-like behaviors in mice: mechanistic intuitions into neuroinflammation and Claudin 5 expression in the hippocampus [0.03%]
实验性结肠炎伴发小鼠社交障碍和类似焦虑的行为：神经炎症及海马Claudin 5表达的机制推测
Sepehr Ebrahimi-Dehkordi,Maryam Anjomshoa,Sorayya Ghasemi et al.
Sepehr Ebrahimi-Dehkordi et al.
Inflammatory bowel disease (IBD) is accompanied by psychiatric disorders, including Schizophrenic-like manifestations. Although incompletely illustrated, intestinal mucosal membrane damage and blood-brain barrier (BBB) penetrability may hav...