Combating Cadmium-Induced Neurotoxicity, Oxidative Stress, and Inflammatory Pathways Using DOPA-31, a Dioxopiperidinamide Derivative in an In Vivo Zebrafish Model [0.03%]
使用DOPA-31（一种二氧哌嗪衍生物）对抗镉诱导的神经毒性、氧化应激和炎症通路：斑马鱼体内模型研究
Santhanam Sanjai Dharshan,S Madesh,Karthikeyan Ramamurthy et al.
Santhanam Sanjai Dharshan et al.
Cadmium (Cd), a prevalent environmental toxin and pollutant capable of causing neurodegenerative diseases (NDs) like Alzheimer's and Parkinson's, primarily through oxidative stress, calcium imbalance, and neuroinflammation-induced mechanism...
Investigation of Malathion-Induced Testicular Inflammation: Role of miR-24-Regulated cGAS-STING Pathway and Autophagy: The Potential Modulatory Effect of Lactobacillus acidophilus [0.03%]
马拉硫磷诱导睾丸炎的机制研究：miR-24调控cGAS-STING信号通路及自噬的作用以及乳酸菌潜在的调节作用
Mai A Abd-Elmawla,Hekmat M El Magdoub,Yara M Aboulmagd et al.
Mai A Abd-Elmawla et al.
Malathion (MAL) exerts serious reproductive toxicity in males and leads to histopathological injuries in seminiferous tubules, sperm abnormalities, and hormonal disruptions such as reduced testosterone levels. The study assessed whether Lac...
Insights Into the Ameliorative Effect of Diacerein on Cyclophosphamide-Induced Testicular Toxicity: Targeting TLR4/NF-κB/IL-1β Pathway [0.03%]
二月桂酸吉派考斯龙改善环磷酰胺所致睾丸毒性的机制研究：靶向TLR4/NF-κB/IL-1β信号途径
Ayaat M Mohamed,Heba A Habib,Gehan H Heeba
Ayaat M Mohamed
Male infertility represents one of the most troublesome of cyclophosphamide (CYP), a frequent chemotherapeutic agent, restricting its clinical usage. Diacerein (DIA), an anthraquinone derivative inhibiting interleukin-1 beta (IL-1β), is of...
Integrated Metabolomic and Biochemical Profiling of Benzodioxane-Derived Hydrazones Targeting Nrf2 to Mitigate Cadmium-Induced Metabolic Dysregulation [0.03%]
苯并二氧杂己环衍生物腙类化合物通过靶向Nrf2作用缓解镉诱导的代谢紊乱的整合代谢组和生化轮廓分析
Aisha Rafique,Muhammad Sajid Hamid Akash,Shagufta Kamal et al.
Aisha Rafique et al.
Benzodioxane-derived hydrazones (BDHs) have emerged as promising antioxidant agents due to their redox-modulatory properties, structural versatility, and ability to activate cellular defense pathways. This study evaluated the protective pot...
MARCH3 Inhibits Tumorigenesis and Enhances Paclitaxel Sensitivity in Nasopharyngeal Carcinoma by Ubiquitinating Hexokinase 2 [0.03%]
MARCH3通过泛素化己糖激酶2抑制鼻咽癌发生及增强紫杉醇敏感性
Xinggu Luo,Qingshan Jiang,Zhifeng Liu et al.
Xinggu Luo et al.
Glycolytic enzyme hexokinase 2 (HK2) plays a crucial role in the development of several human cancers, including nasopharyngeal carcinoma (NPC). This project is designed to explore the role and mechanism of HK2 in NPC progression. HK2 and m...
MicroRNAs as Critical Regulators of Cardiovascular Homeostasis and Disease: Diagnostic and Therapeutic Horizons [0.03%]
microRNA在心血管稳态和疾病中的关键调节作用：诊断与治疗前景
Heba Ibrahim Abd El-Moaty,Ayman A Doghish,Sherif S Abdel Mageed et al.
Heba Ibrahim Abd El-Moaty et al.
Cardiovascular diseases (CVDs) continue to be the world's leading cause of death, driven by intricate processes such as inflammation, endothelial dysfunction, oxidative stress, and apoptosis. MicroRNAs (miRNAs), small non-coding RNAs that i...
MiR-20b-5p Is Involved in Hydroquinone-Induced TK6 Cell Cycle Arrest and Oxidative Damage Through JNK1 Signaling Pathway and Targeting Nrf2 [0.03%]
微RNA-20b-5p通过JNK1信号通路及靶向Nrf2参与对羟基苯醌诱导的TK6细胞周期阻滞和氧化损伤的作用研究
Pu Guo,Xiaoyi Hu,Lingxue Yu et al.
Pu Guo et al.
Hydroquinone (HQ), a metabolic byproduct of benzene, can cause oxidative damage. Oxidative stress triggers the excessive generation of reactive oxygen species (ROS), which in turn elicits diverse forms of cellular injury, including cell cyc...
Classifying Kidney Tumor via Adaptive SE-ResNeXt With Mutli-Novel Loss Function and Renal Mass Segmentation Using Pyramidal Attention-Based R2Unet++ Model [0.03%]
基于自适应SE-ResNeXt与多新颖损失函数的肾脏肿瘤分类及基于金字塔注意力的R2unet++肾病分割模型
Bipin Bihari Jayasingh,H Niroshini Infantia,Tejaswini Panse
Bipin Bihari Jayasingh
Kidney tumors are one of the prevalent types of tumor globally and it has become a significant health concern. It is the most frequent type of urological tumor. While kidney tumors can present in various forms, the majority of the tumors ar...
Sesamol As a Potential Anti-Fibrotic Agent Targeting ECM Dynamics in Oral Submucous Fibrosis [0.03%]
sesameol作为潜在的抗纤维化剂靶向口腔粘膜下纤维化中的细胞外基质动力学
Samreen Ramzan,Amreen Liaquat,Anum Islam et al.
Samreen Ramzan et al.
Oral Submucous Fibrosis (OSMF) is a chronic, progressive, and potentially malignant condition of the oral cavity. Despite the availability of various therapeutic approaches, no single medication has demonstrated complete efficacy in reversi...
miR-652-5p Promotes Neuroinflammation and Mediates Postoperative Cognitive Dysfunction in Rats by Targeting CNTNAP2 [0.03%]
microRNA-652-5p通过靶向CNTNAP2促进神经炎症并介导大鼠术后认知功能障碍
Shuai Wang,Yanyan Jiang,Dalong Wang et al.
Shuai Wang et al.
POCD model in rats was established using isoflurane anesthesia combined with surgery and an in vitro model was constructed by stimulating BV-2 microglial cells with lipopolysaccharide (LPS). A combination of techniques, including open field...