Zihui Gao,Ali Sinehsepehr,Seyed Hadi Hashemi et al.
Zihui Gao et al.
Circulating tumor DNA (ctDNA), a fragment of cell-free DNA derived from malignant cells, has emerged as a promising biomarker in oncology. These DNA fragments carry essential genomic and epigenetic alterations, including point mutations, lo...
Lactic Acid Promotes TNBC Lung Metastasis via TGF-β/Smad-Driven Lipid Metabolic Toxicity and NK Cell Dysfunction [0.03%]
乳酸通过TGF-β/Smad驱动的脂质代谢毒性促进三阴性乳腺癌肺转移和NK细胞功能障碍
Peiling Zhu,Zhisheng Tian,Ying Wang et al.
Peiling Zhu et al.
Lactic acid in the tumor microenvironment (TME) drives triple-negative breast cancer (TNBC) progression by coordinately reprogramming lipid metabolism and suppressing immune function. RNA-Seq analysis of lactate-treated MDA-MB-231 and NK-92...
Upregulation of lncRNA SATB1-AS1 in Serum Promotes Sepsis Progression By Suppressing miR-124-3p and Enhancing Inflammatory Mediator Release [0.03%]
血清中长链非编码 RNA SATB1-AS1 的上调通过抑制 miR-124-3p 和增强炎性介质的释放促进脓毒症的发展
Lihong Zhang,Yi Gu,Lin Yang et al.
Lihong Zhang et al.
Sepsis is a life-threatening systemic inflammatory response syndrome. The long non-coding RNA SATB1-AS1 exhibits abnormal expression in blood samples from sepsis patients. This study explores the regulatory role of SATB1-AS1 in sepsis. This...
Cannabidiol Protects Against 1-Methyl-4-Phenylpyridinium and Manganese-Induced Neurotoxicity via Nod-Like Receptor Protein 3 Inflammasome Suppression [0.03%]
大麻二酚通过抑制NLRP3炎性小体保护神经毒性
Göksun Demirel,Anıl Yirün,Deniz Arca Çakir et al.
Göksun Demirel et al.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neurodegeneration, alpha-synuclein (α-Syn) accumulation, and neuroinflammation. The NOD-Like Receptor (NLR) family pyrin domain containing 3 NLRP3 infla...
Exploring the Anticancer Potential of Pterostilbene Through Modulation of the NRF2-NFκB-COX-2 Network [0.03%]
通过调节NRF2-NFκB-COX-2网络探讨白藜芦醇茋的抗肿瘤潜力
Kunka Mohanram Ramkumar,Goutham V Ganesh,Vipin Gopinath et al.
Kunka Mohanram Ramkumar et al.
Pterostilbene (PTS) is a naturally occurring analogue of resveratrol (RES) with high bioavailability, making it a promising alternative for diverse biological applications. PTS exhibits dose-dependent effects on cellular signaling, which re...
Dynorphin B Promotes Autophagy and Cytotoxicity in Thyroid Cancer Cells via the mTORC1-TFE3 Axis [0.03%]
Dynorphin B通过mTORC1-TFE3轴促进甲状腺癌细胞自噬和细胞毒性
Xuesong Wu,Xuesong Zhai,Lizhen Ren et al.
Xuesong Wu et al.
Autophagy can either support tumor survival or induce cell death in thyroid cancer. This process is a promising therapeutic target. This study aimed to investigate the effects and molecular mechanisms of Dynorphin B in TPC-1 thyroid cancer ...
Neurobehavioral Toxicity of Acetamiprid in Male Rats and the Protective Role of Resveratrol: The Involvement of the PI3K/Akt/BDNF Pathway [0.03%]
茋对乙基됨feldram所致雄性大鼠神经行为毒性的保护作用及PI3K/Akt/BDNF信号通路的介导效应研究
Mohamed S Hassan,Ashraf M Morgan,Marwa A Ibrahim et al.
Mohamed S Hassan et al.
This study investigated the neurobehavioral toxicity of Acetamiprid (ACP), a neonicotinoid insecticide, in male rats and evaluated the potential neuroprotective effects of Resveratrol (RSV), a natural antioxidant found in grapes and peanuts...
Zingerone Inhibits ox-LDL-Induced Human Coronary Artery Endothelial Cells Senescence and Apoptosis in Association With Downregulation of HSP90AB1 in Coronary Artery Atherosclerotic Heart Disease [0.03%]
姜辣素通过下调HSP90AB1抑制冠状动脉粥样硬化患者内皮细胞衰老和凋亡
Shucan Ma,Ru Li,Zhifen Liu et al.
Shucan Ma et al.
Zingerone (Zin) exhibits multiple pharmacological properties, including anti-inflammatory, immunomodulatory, anxiolytic, anti-thrombotic, radioprotective, and antimicrobial activities. However, the therapeutic potential of Zin in coronary a...
Sevoflurane Alleviates Hypoxia/Reoxygenation-Induced Myocardial Injury by Regulating miR-300: An In Vitro Study [0.03%]
异氟醚通过调节miR-300缓解缺氧复氧诱导的心肌损伤：一项体外研究
Chenyu Wang,Zhenyun Tao,Shuai Wang et al.
Chenyu Wang et al.
The myocardial protective effect of sevoflurane (Sev) has been confirmed, but its potential molecular mechanism remains not fully elucidated. To unravel the functional contribution and mechanistic basis of miR-300, its involvement in sevofl...