Cannabidiol Protects Against 1-Methyl-4-Phenylpyridinium and Manganese-Induced Neurotoxicity via Nod-Like Receptor Protein 3 Inflammasome Suppression [0.03%]
大麻二酚通过抑制NLRP3炎性小体保护神经毒性
Göksun Demirel,Anıl Yirün,Deniz Arca Çakir et al.
Göksun Demirel et al.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neurodegeneration, alpha-synuclein (α-Syn) accumulation, and neuroinflammation. The NOD-Like Receptor (NLR) family pyrin domain containing 3 NLRP3 infla...
Exploring the Anticancer Potential of Pterostilbene Through Modulation of the NRF2-NFκB-COX-2 Network [0.03%]
通过调节NRF2-NFκB-COX-2网络探讨白藜芦醇茋的抗肿瘤潜力
Kunka Mohanram Ramkumar,Goutham V Ganesh,Vipin Gopinath et al.
Kunka Mohanram Ramkumar et al.
Pterostilbene (PTS) is a naturally occurring analogue of resveratrol (RES) with high bioavailability, making it a promising alternative for diverse biological applications. PTS exhibits dose-dependent effects on cellular signaling, which re...
Dynorphin B Promotes Autophagy and Cytotoxicity in Thyroid Cancer Cells via the mTORC1-TFE3 Axis [0.03%]
Dynorphin B通过mTORC1-TFE3轴促进甲状腺癌细胞自噬和细胞毒性
Xuesong Wu,Xuesong Zhai,Lizhen Ren et al.
Xuesong Wu et al.
Autophagy can either support tumor survival or induce cell death in thyroid cancer. This process is a promising therapeutic target. This study aimed to investigate the effects and molecular mechanisms of Dynorphin B in TPC-1 thyroid cancer ...
Neurobehavioral Toxicity of Acetamiprid in Male Rats and the Protective Role of Resveratrol: The Involvement of the PI3K/Akt/BDNF Pathway [0.03%]
茋对乙基됨feldram所致雄性大鼠神经行为毒性的保护作用及PI3K/Akt/BDNF信号通路的介导效应研究
Mohamed S Hassan,Ashraf M Morgan,Marwa A Ibrahim et al.
Mohamed S Hassan et al.
This study investigated the neurobehavioral toxicity of Acetamiprid (ACP), a neonicotinoid insecticide, in male rats and evaluated the potential neuroprotective effects of Resveratrol (RSV), a natural antioxidant found in grapes and peanuts...
Zingerone Inhibits ox-LDL-Induced Human Coronary Artery Endothelial Cells Senescence and Apoptosis in Association With Downregulation of HSP90AB1 in Coronary Artery Atherosclerotic Heart Disease [0.03%]
姜辣素通过下调HSP90AB1抑制冠状动脉粥样硬化患者内皮细胞衰老和凋亡
Shucan Ma,Ru Li,Zhifen Liu et al.
Shucan Ma et al.
Zingerone (Zin) exhibits multiple pharmacological properties, including anti-inflammatory, immunomodulatory, anxiolytic, anti-thrombotic, radioprotective, and antimicrobial activities. However, the therapeutic potential of Zin in coronary a...
Sevoflurane Alleviates Hypoxia/Reoxygenation-Induced Myocardial Injury by Regulating miR-300: An In Vitro Study [0.03%]
异氟醚通过调节miR-300缓解缺氧复氧诱导的心肌损伤：一项体外研究
Chenyu Wang,Zhenyun Tao,Shuai Wang et al.
Chenyu Wang et al.
The myocardial protective effect of sevoflurane (Sev) has been confirmed, but its potential molecular mechanism remains not fully elucidated. To unravel the functional contribution and mechanistic basis of miR-300, its involvement in sevofl...
Deinoxanthin Overcomes P-Glycoprotein-Mediated Multidrug Resistance in Breast Cancer Cells [0.03%]
脱氧色素克服乳腺癌细胞中P-糖蛋白介导的多药耐药性
Susithra Babu,Karankumar Balamurugan,Sugumar Baskar et al.
Susithra Babu et al.
Multidrug resistance (MDR) remains a critical barrier in effective cancer chemotherapy which is largely attributed to the overexpression of ATP-binding cassette (ABC) transporters. P-glycoprotein (P-gp) is the major ABC transporter which ac...
Inhibition of PI3K/Akt/mTOR/JAK-2/STAT-3 Signalling Pathways via Ligustrazine in Alcoholic Liver Disease Associated Neurological Dysfunction [0.03%]
淫羊藿素通过PI3K/Akt/mTOR/JAK-2/STAT-3信号通路抑制酒精性肝病相关神经功能损伤
Aarti Tiwari,Pradeep Kumar Samal
Aarti Tiwari
Alcoholic liver disease (ALD) is a prevalent chronic hepatic disorder characterized by the abnormal accumulation of fat in the liver. Current treatments for ALD primarily focus on liver function and metabolic concerns; however, emerging evi...
Protective Effect of Lycopene Against Oxaliplatin-Induced Nephrotoxicity by Modulation NF-κB/TNF-α/IL-1β, P53/Bax/Bcl2, and PI3K/AKT/mTOR Signaling Pathway [0.03%]
番茄红素通过调节NF-κB/TNF-α/IL-1β、P53/Bax/Bcl2以及PI3K/Akt/mTOR信号通路对抗奥沙利铂诱导的肾毒性的作用机制研究
Özge Kandemir,Sefa Küçükler,Selim Çomaklı et al.
Özge Kandemir et al.
Oxaliplatin (OXI), a platinum-based chemotherapeutic agent commonly used in colorectal Cancer treatment, has been linked to significant nephrotoxicity involving apoptosis, endoplasmic reticulum (ER) stress, inflammation, oxidative stress, a...
Role of Luteolin in Prevention of Oral, Esophageal, Gastric, Pancreatic, and Colon Cancers: Recent Trends and Future Perspectives [0.03%]
黄芩素在预防口腔、食管、胃、胰腺和结直肠癌中的作用：最近的趋势和未来展望
Abhilasha Sood,Arpit Mehrotra,Soniya Goyal et al.
Abhilasha Sood et al.
Cancers such as oral, esophageal, gastric, pancreatic, and colorectal malignancies represent a significant global health burden. Amid continuous efforts to develop effective pharmacological interventions, the natural flavonoid luteolin, whi...