Pierre-François Dequin,Marco Confalonieri
Pierre-François Dequin
Despite a fairly large number of comparative trials (which are, however, very heterogeneous), the role of corticosteroids in the adjuvant treatment of community-acquired pneumonia remains controversial. Nevertheless, recent randomized trial...
The Glucocorticoid System: A Multifaceted Regulator of Mitochondrial Function, Endothelial Homeostasis, and Intestinal Barrier Integrity [0.03%]
糖皮质激素系统：线粒体功能、内皮稳态和肠屏障完整性的多面调节器
G Umberto Meduri,Anna-Maria G Psarra
G Umberto Meduri
Critical illness initiates a cascade of systemic disturbances-including energy deficits, oxidative stress, endothelial injury, and intestinal barrier dysfunction. Mitochondria, the vascular endothelium, and the intestinal barrier are three ...
Lori Sakoda,Louise Henderson
Lori Sakoda
To be addedIn this review, we summarize recent evidence from approximately the last five years across the lung cancer screening (LCS) care continuum. First, we review the results from the NELSON trial, from the extended follow-up of other L...
Glucocorticoid Treatment in Severe COPD Exacerbations: Biological Rationale, Clinical Effects, and Practical Advice [0.03%]
重度COPD急性加重的糖皮质激素治疗：生物学依据、临床疗效及实用建议
Filippo Sartori,Giulia Sartori,Claudia Di Chiara et al.
Filippo Sartori et al.
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD), particularly those requiring hospitalization or intensive care unit (ICU) admission, represent a significant clinical and prognostic burden. Systemic corticosteroids rem...
Glucocorticoids and GRα Signaling in Critical Illness: Phase-Specific Homeostatic Corrections Across Systems [0.03%]
危重病状态下糖皮质激素与GRα信号转导：跨系统特异性稳态校正
G Umberto Meduri
G Umberto Meduri
Glucocorticoid (GC)-activated glucocorticoid receptor α (GRα) signaling-underpins survival and recovery during severe physiological stress. Rooted in evolution, these adjustments are not mere damage control; they constitute a coordinated,...
Jiao Liu,Qian Xing,Xiaojun Pan et al.
Jiao Liu et al.
Septic shock, the most severe manifestation of sepsis, is characterized by profound circulatory failure and carries the highest mortality risk among sepsis-related conditions. Current therapeutic strategies remain primarily supportive, emph...
Heterogeneity of Lung Phagocytes and Clearance of Apoptotic Cells in Lung Injury and Repair [0.03%]
肺损伤与修复过程中肺吞噬细胞的异质性及其清除凋亡细胞的作用
Stephanie M Bersie,Alexandra L McCubbrey
Stephanie M Bersie
Poor repair following lung injury is a significant cause of morbidity and mortality. Clearance of apoptotic cells, termed efferocytosis, has emerged as a key process that can influence repair outcomes and facilitate successful repair. Altho...
Glucocorticoid Treatment in Hospital-Acquired and Ventilator-Associated Pneumonia [0.03%]
医院获得性和机械通气相关性肺炎的糖皮质激素治疗
Cecile Poulain,Marwan Bouras,Antoine Roquilly
Cecile Poulain
Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) remain among the most frequent complications in critically ill patients. Despite the implementation of modern preventive strategies and the widespread use of broad-...
Factors Influencing Glucocorticoid Treatment Response: Mechanism-Based Strategies to Overcome Glucocorticoid Resistance and Restore GRα Function [0.03%]
影响糖皮质激素治疗反应的因素：基于机制的策略克服糖皮质激素抵抗和恢复GRα功能
G U Meduri
G U Meduri
(word count 290) Glucocorticoids (GCs) remain central to managing dysregulated systemic inflammation in critical illness, yet therapeutic response varies widely due to multifactorial glucocorticoid resistance (GCR). This chapter provides a ...
Reimagining Fibrosis Research, Outcomes, and Therapeutics Through the Lens of Resolution [0.03%]
从解析角度重新思考纤维化研究、结果和治疗
Sean M Fortier,Elizabeth F Redente,Marc Peters-Golden
Sean M Fortier
Tissue fibrosis contributes to progressive organ dysfunction in a multitude of chronic human diseases. Despite decades of ongoing research dedicated to determining the cellular and molecular origins of fibrosis across multiple organs, we co...