Heterogeneity of Lung Phagocytes and Clearance of Apoptotic Cells in Lung Injury and Repair [0.03%]
肺损伤与修复过程中肺吞噬细胞的异质性及其清除凋亡细胞的作用
Stephanie M Bersie,Alexandra L McCubbrey
Stephanie M Bersie
Poor repair following lung injury is a significant cause of morbidity and mortality. Clearance of apoptotic cells, termed efferocytosis, has emerged as a key process that can influence repair outcomes and facilitate successful repair. Altho...
Glucocorticoid Treatment in Hospital-Acquired and Ventilator-Associated Pneumonia [0.03%]
医院获得性和机械通气相关性肺炎的糖皮质激素治疗
Cecile Poulain,Marwan Bouras,Antoine Roquilly
Cecile Poulain
Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) remain among the most frequent complications in critically ill patients. Despite the implementation of modern preventive strategies and the widespread use of broad-...
Factors Influencing Glucocorticoid Treatment Response: Mechanism-Based Strategies to Overcome Glucocorticoid Resistance and Restore GRα Function [0.03%]
影响糖皮质激素治疗反应的因素：基于机制的策略克服糖皮质激素抵抗和恢复GRα功能
G U Meduri
G U Meduri
(word count 290) Glucocorticoids (GCs) remain central to managing dysregulated systemic inflammation in critical illness, yet therapeutic response varies widely due to multifactorial glucocorticoid resistance (GCR). This chapter provides a ...
Reimagining Fibrosis Research, Outcomes, and Therapeutics Through the Lens of Resolution [0.03%]
从解析角度重新思考纤维化研究、结果和治疗
Sean M Fortier,Elizabeth F Redente,Marc Peters-Golden
Sean M Fortier
Tissue fibrosis contributes to progressive organ dysfunction in a multitude of chronic human diseases. Despite decades of ongoing research dedicated to determining the cellular and molecular origins of fibrosis across multiple organs, we co...
Lynn Y-W Shong,David C-L Lam
Lynn Y-W Shong
Lung cancer remains the leading cause of cancer-related deaths worldwide, with its burden shaped by evolving risk factors, demographic changes, and healthcare disparities. Over the past decades, while age-standardized incidence and mortalit...
Daniel Scullin,Joseph Barney
Daniel Scullin
Neuromuscular diseases encompass a wide array of clinical manifestations, age at presentation, and severity of morbidity and mortality. Central to most patients with these disorders are symptoms of dyspnea and increased work of breathing re...
Peeling Back the Layers of the Bleomycin Model of Lung Fibrosis: Lessons Learned, Factors to Consider, and Future Directions [0.03%]
剥开肺纤维化博来霉素模型的层面：吸取教训、考虑因素和未来方向
Patricia Brazee,Nancy Allen,Rachel Knipe et al.
Patricia Brazee et al.
Bleomycin-induced lung injury remains the most widely used and well-characterized experimental model for studying pulmonary fibrosis, particularly idiopathic pulmonary fibrosis (IPF). This review provides a comprehensive analysis of the ble...
Matthew Triplette,Melinda C Aldrich
Matthew Triplette
Lung cancer is the leading cause of cancer deaths worldwide, claiming more lives than other age-related and screen-detectable cancers. Cigarette smoking remains the most important risk factor. However, despite common perceptions, risk is no...
Yunan Nie,Anne C Chiang
Yunan Nie
Small-cell lung cancer (SCLC) is a high-grade, aggressive neuroendocrine tumor with a particularly poor prognosis, characterized by early metastases and rapid development of therapy resistance. There have historically been few treatment opt...
Ferran Barbé,Adriano D S Targa,David Gozal
Ferran Barbé