Limitations in the Design of Critical Care Studies and Suggestions for Future Research Directions [0.03%]
重症监护研究设计的局限性及对未来研究方向的建议
Guanfranco Umberto Meduri,Simone Lannini,Jim M Smit
Guanfranco Umberto Meduri
Glucocorticoid (GC) therapy has been a cornerstone of critical care; however, its full potential has been constrained by fixed-dose regimens and trial designs that predate current insights into the dynamic, phase-specific functions of gluco...
Pulmonary Infections in Patients Receiving Corticosteroids and Other Immunomodulators [0.03%]
接受皮质类固醇和其他免疫调节剂治疗患者的肺部感染
Emily S Hartman,Rodrigo Cavallazzi
Emily S Hartman
The prevalence of immunosuppression in the general population has been increasing over time due to a combination of factors, including advances in health care and the emergence of new therapies. Population-based studies show that approximat...
Monographic Issue on Glucocorticoid Therapy in Critical Illness and Respiratory Disease [0.03%]
重症和呼吸系统疾病糖皮质激素治疗专题研究
Guanfranco Umberto Meduri,Antoni Torres
Guanfranco Umberto Meduri
Pascalin Roy,Sara Shadchehr,Anne Gonzalez
Pascalin Roy
Lung cancer is the leading cause of cancer incidence and mortality worldwide. Pulmonologists play a central role in the timely, guideline-concordant diagnosis and staging of lung cancer. Minimally invasive procedures must also provide suffi...
Advanced pulmonary sarcoidosis [0.03%]
重症肺结节病
Paolo Spagnolo,Zehra Dhanani,Paolo Cameli et al.
Paolo Spagnolo et al.
In sarcoidosis, pulmonary manifestations are almost universal; however, their severity ranges from asymptomatic to respiratory failure and death. Approximately 20% of patients progress to advanced pulmonary sarcoidosis (APS), a disease phen...
Neurosarcoidosis in Critical Care, Internal and Pulmonary Medicine: A Practical Approach [0.03%]
重症监护、内科和肺科神经肉芽肿病：实用方法
Munther M Queisi,Carlos A Pardo
Munther M Queisi
Neurosarcoidosis is a rare but clinically significant manifestation of sarcoidosis, often presenting with diverse neurologic symptoms that can lead to permanent disability if left untreated. This review aims to provide internists, pulmonolo...
Top 7 Diagnostic Dilemmas in Cardiac Sarcoidosis: Lessons from Clinical Practice [0.03%]
心脏肉芽肿病诊断的七大难题：临床经验教训
Anjali A Wagle,Irena Kuzma,Nisha A Gilotra
Anjali A Wagle
Cardiac sarcoidosis (CS) is a potentially fatal but often underrecognized manifestation of systemic sarcoidosis. Its diagnosis remains a major clinical challenge due to nonspecific symptoms, overlapping features with other cardiac and genet...
Genetics in Sarcoidosis and Its Burden as a Multisystem Disease [0.03%]
遗传学在 sarcoidosis 及其作为多系统疾病负担中的作用
Natalia V Rivera,Anders Eklund
Natalia V Rivera
Sarcoidosis is a complex, immune-mediated disease characterized by a broad spectrum of clinical and molecular phenotypes-often referred to as endophenotypes-some of which progress to chronic outcomes such as pulmonary fibrosis. Despite deca...
Critical Challenges: Respiratory Infections in Immunocompromised ICU Patients [0.03%]
免疫抑制ICU患者的呼吸道感染之关键挑战
Catia Cilloniz,Julio Ramirez
Catia Cilloniz
María Florencia Pilia,David Espejo-Castellanos,Christian Romero-Mesones et al.
María Florencia Pilia et al.
Severe asthma affects approximately 3-10% of the asthmatic population and is characterized by persistent symptoms and frequent exacerbations despite high-intensity therapy. Historically, glucocorticoids (GCs) have been the mainstay of treat...