Paula O Narvaez-Ramirez,Cristian C Serrano-Mayorga,Ingrid G Bustos et al.
Paula O Narvaez-Ramirez et al.
Solid organ transplantation (SOT) has significantly increased over the past few decades, with more than 170,000 SOTs performed worldwide in 2023. Although immunosuppressive treatments have improved patient survival, they have also increased...
Terra C Swanson,Brent W Kinder,Joshua M Clark
Terra C Swanson
The National Cancer Institute (NCI) estimates that over 2 million Americans will be diagnosed with cancer in 2025. A significant proportion of these patients will receive chemotherapeutics, radiation, molecularly targeted therapies, or immu...
Michael Z Root,Joyce S Lee
Michael Z Root
Cryptogenic organizing pneumonia (COP), formerly called bronchiolitis obliterans organizing pneumonia (BOOP), was first described in the 1980s and is classified as a rare idiopathic interstitial pneumonia (IIP). COP classically presents in ...
Christopher F Pastore,Brennan D Stadler,Anne Sperling et al.
Christopher F Pastore et al.
Chronic lung disease is a sequela of unresolving pathogenesis in the lung. Current estimates report approximately 7.4% of the world's population live with chronic respiratory diseases. The architectural differences in the airways and indivi...
Pierre-François Dequin,Marco Confalonieri
Pierre-François Dequin
Despite a fairly large number of comparative trials (which are, however, very heterogeneous), the role of corticosteroids in the adjuvant treatment of community-acquired pneumonia remains controversial. Nevertheless, recent randomized trial...
The Glucocorticoid System: A Multifaceted Regulator of Mitochondrial Function, Endothelial Homeostasis, and Intestinal Barrier Integrity [0.03%]
糖皮质激素系统：线粒体功能、内皮稳态和肠屏障完整性的多面调节器
G Umberto Meduri,Anna-Maria G Psarra
G Umberto Meduri
Critical illness initiates a cascade of systemic disturbances-including energy deficits, oxidative stress, endothelial injury, and intestinal barrier dysfunction. Mitochondria, the vascular endothelium, and the intestinal barrier are three ...
Lori Sakoda,Louise Henderson
Lori Sakoda
To be addedIn this review, we summarize recent evidence from approximately the last five years across the lung cancer screening (LCS) care continuum. First, we review the results from the NELSON trial, from the extended follow-up of other L...
Glucocorticoid Treatment in Severe COPD Exacerbations: Biological Rationale, Clinical Effects, and Practical Advice [0.03%]
重度COPD急性加重的糖皮质激素治疗：生物学依据、临床疗效及实用建议
Filippo Sartori,Giulia Sartori,Claudia Di Chiara et al.
Filippo Sartori et al.
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD), particularly those requiring hospitalization or intensive care unit (ICU) admission, represent a significant clinical and prognostic burden. Systemic corticosteroids rem...
Glucocorticoids and GRα Signaling in Critical Illness: Phase-Specific Homeostatic Corrections Across Systems [0.03%]
危重病状态下糖皮质激素与GRα信号转导：跨系统特异性稳态校正
G Umberto Meduri
G Umberto Meduri
Glucocorticoid (GC)-activated glucocorticoid receptor α (GRα) signaling-underpins survival and recovery during severe physiological stress. Rooted in evolution, these adjustments are not mere damage control; they constitute a coordinated,...
Jiao Liu,Qian Xing,Xiaojun Pan et al.
Jiao Liu et al.
Septic shock, the most severe manifestation of sepsis, is characterized by profound circulatory failure and carries the highest mortality risk among sepsis-related conditions. Current therapeutic strategies remain primarily supportive, emph...