Complications Associated with Glucocorticoids Treatment in Critically Ill Patients [0.03%]
危重病人的糖皮质激素治疗并发症
Paola Confalonieri,Nicolò Reccardini,Stefano Kette et al.
Paola Confalonieri et al.
Glucocorticoids (GCs) are essential immunomodulatory agents in the management of critically ill patients with severe systemic inflammation, particularly in conditions such as sepsis, acute respiratory distress syndrome, and severe community...
Malignancies Presenting with Alveolar Infiltrates: Diagnostic Pitfalls, Radiologic Clues, and Clinical Patterns [0.03%]
以肺泡浸润表现为特征的恶性肿瘤：诊断陷阱、影像学征象和临床模式
Akshay Mathavan,Akash Mathavan,Olga Gomez-Rojas et al.
Akshay Mathavan et al.
Alveolar infiltrates are a common but nonspecific radiologic finding that can obscure the diagnosis of underlying malignancy. While infections and inflammatory processes are typical considerations, a subset of cancers, both primary and seco...
Sushma Jonna,Jowan Al-Nusair,Giordano F Cittolin Santos et al.
Sushma Jonna et al.
Lung cancer represents the most common cause of cancer-related mortality globally, with non-small cell lung cancer (NSCLC) comprising the vast majority of cases. Outcomes for stage II-III NSCLC remain suboptimal due to late presentation, bi...
Lysosomal storage disorders [0.03%]
溶酶体贮积病
Jacopo Cefalo,Bruno Crestani,Alice Guyard et al.
Jacopo Cefalo et al.
Lysosomes are intra-cellular organelles that are responsible for degrading and recycling macromolecules. Lysosomal diseases (LDs) are a group of rare inherited diseases caused by deleterious variants affecting genes that encode the lysosoma...
Emerging Concepts in Pathogenesis, Multiomics Applications, and Clinical Research in Lymphangioleiomyomatosis [0.03%]
淋巴管平滑肌瘤病的发病机制、多组学应用和临床研究新概念
Jane J Yu,Nishant Gupta,Minzhe Guo et al.
Jane J Yu et al.
Lymphangioleiomyomatosis (LAM) is a rare, female-predominant, low-grade neoplasm characterized by infiltration of abnormal smooth muscle-like and epithelioid cells into the lung parenchyma, leading to cystic changes and progressive respirat...
General Approach to Immunocompromised Patients with Pneumonia: Insights from the Latest Consensus Documents [0.03%]
免疫缺陷患者肺炎诊治要点——最新共识解读
Julio Ramirez
Julio Ramirez
Immunocompromised adults with pneumonia represent a growing and heterogeneous patient population requiring a tailored diagnostic and therapeutic approach. This review synthesizes insights from the latest consensus documents and guidelines t...
Paula O Narvaez-Ramirez,Cristian C Serrano-Mayorga,Ingrid G Bustos et al.
Paula O Narvaez-Ramirez et al.
Solid organ transplantation (SOT) has significantly increased over the past few decades, with more than 170,000 SOTs performed worldwide in 2023. Although immunosuppressive treatments have improved patient survival, they have also increased...
Terra C Swanson,Brent W Kinder,Joshua M Clark
Terra C Swanson
The National Cancer Institute (NCI) estimates that over 2 million Americans will be diagnosed with cancer in 2025. A significant proportion of these patients will receive chemotherapeutics, radiation, molecularly targeted therapies, or immu...
Michael Z Root,Joyce S Lee
Michael Z Root
Cryptogenic organizing pneumonia (COP), formerly called bronchiolitis obliterans organizing pneumonia (BOOP), was first described in the 1980s and is classified as a rare idiopathic interstitial pneumonia (IIP). COP classically presents in ...
Christopher F Pastore,Brennan D Stadler,Anne Sperling et al.
Christopher F Pastore et al.
Chronic lung disease is a sequela of unresolving pathogenesis in the lung. Current estimates report approximately 7.4% of the world's population live with chronic respiratory diseases. The architectural differences in the airways and indivi...