Takahiro Kodama,Tetsuo Takehara
Takahiro Kodama
This review examines the latest epidemiological and molecular pathogenic findings of metabolic-associated hepatocellular carcinoma (HCC). Its increasing prevalence is a significant concern and reflects the growing burden of obesity and meta...
Marialena Mouzaki,Jessica G Woo,Senad Divanovic
Marialena Mouzaki
Pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) is common and can be seen as early as in utero. A growing body of literature suggests that gestational and early life exposures modify the risk of MASLD development ...
Anna Tutusaus,Albert Morales,Pablo García de Frutos et al.
Anna Tutusaus et al.
TAM (TYRO3, AXL, and MERTK) protein tyrosine kinase membrane receptors and their vitamin K-dependent ligands GAS6 and protein S (PROS) are well-known players in tumor biology and autoimmune diseases. In contrast, TAM regulation of fibrogene...
UDCA for Drug-Induced Liver Disease: Clinical and Pathophysiological Basis [0.03%]
UDCA对药物性肝病的临床和病理生理学依据
Fernando Bessone,Geraldine L Hillotte,Natalia Ahumada et al.
Fernando Bessone et al.
Drug-induced liver injury (DILI) is an adverse reaction to medications and other xenobiotics that leads to liver dysfunction. Based on differential clinical patterns of injury, DILI is classified into hepatocellular, cholestatic, and mixed ...
Tailored Model of Care for Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease [0.03%]
与代谢功能障碍相关性脂肪肝疾病的个体化治疗模型
Mohamed El-Kassas,Abeer Awad,Mohamed Elbadry et al.
Mohamed El-Kassas et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), is increasing globally, creating a growing public health concern. However, this disease is often not diagnosed, an...
Algorithms for Early Detection of Silent Liver Fibrosis in the Primary Care Setting [0.03%]
初级保健环境中早期检测隐性肝纤维化的算法
Katrine Tholstrup Bech,Katrine Prier Lindvig,Maja Thiele et al.
Katrine Tholstrup Bech et al.
More than one-third of the adult world population has steatotic liver disease (SLD), with a few percent of individuals developing cirrhosis after decades of silent liver fibrosis accumulation. Lack of systematic early detection causes most ...
Liver Transplantation for Hepatocellular Carcinoma: A Narrative Review and A Glimpse into The Future [0.03%]
肝细胞癌的肝脏移植：一项叙述性综述及对未来的展望
Hao Liu,Vrishketan Sethi,Xingjie Li et al.
Hao Liu et al.
Liver transplantation (LT) is a highly effective treatment for carefully selected patients with hepatocellular carcinoma (HCC). In this review, we explored the development of LT selection criteria and organ allocation policies, comparing or...
Novel Therapeutic Approaches in Treatment of Acute-on-Chronic Liver Failure [0.03%]
急性-on-慢性肝衰竭的新型治疗策略
MohammadMahdi Saeidinejad,Ahmed Elshabrawi,Supachaya Sriphoosanaphan et al.
MohammadMahdi Saeidinejad et al.
Acute-on-chronic liver failure (ACLF), a clinical syndrome that can develop at any stage in the progression of cirrhotic liver disease, is characterized by an acute decompensation in liver function with associated multiorgan failure and hig...
Cathrin L C Gudd,Roosey Sheth,Mark R Thursz et al.
Cathrin L C Gudd et al.
In recent years cancer treatment has been revolutionized by the development and wide application of checkpoint inhibitor (CPI) drugs, which are a form of immunotherapy. CPI treatment is associated with immune-related adverse events, off-tar...
Oluwashanu Balogun,Kari Nejak-Bowen
Oluwashanu Balogun
The porphyrias are a group of metabolic disorders that are caused by defects in heme biosynthesis pathway enzymes. The result is accumulation of heme precursors, which can cause neurovisceral and/or cutaneous photosensitivity. Liver is comm...