Liver Transplantation for Hepatocellular Carcinoma: A Narrative Review and A Glimpse into The Future [0.03%]
肝细胞癌的肝脏移植：一项叙述性综述及对未来的展望
Hao Liu,Vrishketan Sethi,Xingjie Li et al.
Hao Liu et al.
Liver transplantation (LT) is a highly effective treatment for carefully selected patients with hepatocellular carcinoma (HCC). In this review, we explored the development of LT selection criteria and organ allocation policies, comparing or...
Novel Therapeutic Approaches in Treatment of Acute-on-Chronic Liver Failure [0.03%]
急性-on-慢性肝衰竭的新型治疗策略
MohammadMahdi Saeidinejad,Ahmed Elshabrawi,Supachaya Sriphoosanaphan et al.
MohammadMahdi Saeidinejad et al.
Acute-on-chronic liver failure (ACLF), a clinical syndrome that can develop at any stage in the progression of cirrhotic liver disease, is characterized by an acute decompensation in liver function with associated multiorgan failure and hig...
Cathrin L C Gudd,Roosey Sheth,Mark R Thursz et al.
Cathrin L C Gudd et al.
In recent years cancer treatment has been revolutionized by the development and wide application of checkpoint inhibitor (CPI) drugs, which are a form of immunotherapy. CPI treatment is associated with immune-related adverse events, off-tar...
Oluwashanu Balogun,Kari Nejak-Bowen
Oluwashanu Balogun
The porphyrias are a group of metabolic disorders that are caused by defects in heme biosynthesis pathway enzymes. The result is accumulation of heme precursors, which can cause neurovisceral and/or cutaneous photosensitivity. Liver is comm...
Sierra R Wilson,Andrew W Duncan
Sierra R Wilson
The liver's unique chromosomal variations, including polyploidy and aneuploidy, influence hepatocyte identity and function. Among the most well-studied mammalian polyploid cells, hepatocytes exhibit a dynamic interplay between diploid and p...
Fátima Manzano-Núñez,Lara Prates Tiago Aguilar,Christine Sempoux et al.
Fátima Manzano-Núñez et al.
Biliary tract cancer is a devastating malignancy of the bile ducts and gallbladder with a dismal prognosis. The study of precancerous lesions has received considerable attention and led to a histopathological classification which, in some r...
Unraveling the Complexities of Immune Checkpoint Inhibitors in Hepatocellular Carcinoma [0.03%]
肝细胞癌免疫检查点抑制剂治疗的复杂性解析
Xinpu Han,Qianhui Sun,Manman Xu et al.
Xinpu Han et al.
Immune checkpoint inhibitors (ICIs) have emerged as effective therapeutics for multiple cancers. Nevertheless, as immunotherapeutic approaches are being extensively utilized, substantial hurdles have arisen for clinicians. These include cou...
Erratum to: Genetic Contributions to Biliary Atresia: A Developmental Cholangiopathy [0.03%]
遗传因素对胆道闭锁的贡献：一种发育性胆管疾病
Dominick J Hellen,Saul J Karpen
Dominick J Hellen
Published Erratum
Seminars in liver disease. 2023 Aug;43(3):e2. DOI:10.1055/s-0043-1776036 2023
Brian Pearlman
Brian Pearlman
Published Erratum
Seminars in liver disease. 2023 Aug;43(3):e1. DOI:10.1055/s-0043-1776037 2023
Rajesh Kumar Dutta,JiHye Jun,Kuo Du et al.
Rajesh Kumar Dutta et al.
The purpose of this review is to summarize current knowledge about the role of the Hedgehog signaling pathway in liver homeostasis and disease. Hedgehog is a morphogenic signaling pathway that is active in development. In most healthy tissu...