Elevated Uric Acid and Metabolic Dysfunction-Associated Steatotic Liver Disease Progression: Where There's Smoke, is There Fire? [0.03%]
尿酸升高与代谢功能障碍相关脂肪性肝病进展：有烟必有火吗？
Eric E Kelley,Owen M Woodward,Nicholas K H Khoo
Eric E Kelley
Hyperuricemia and metabolic dysfunction-associated steatotic liver disease share overlapping risk factors, yet the mechanistic contribution of uric acid remains unclear. Generation of uric acid occurs exclusively by xanthine oxidoreductase,...
Richa Gupta,Rodrigo M Florentino,Amala Alenchery et al.
Richa Gupta et al.
Bile secretion is dependent on the structural and functional integrity of membrane transport systems in hepatocytes and cholangiocytes. Progressive familial intrahepatic cholestasis (PFIC) is a heterogeneous group of disorders resulting fro...
Metabolic Dysfunction-Associated Steatotic Liver Disease Reprograms the Hepatic Metastatic Niche [0.03%]
代谢功能异常相关性脂肪肝病重新编程肝脏转移微环境
Mustafa Karabicici,Ekihiro Seki
Mustafa Karabicici
Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized as a driver of metastatic progression in the liver. In addition to its association with hepatocellular carcinoma, the steatotic liver supports metas...
Kathryn Thompson,Hima Veeramachaneni,Ram Subramanian
Kathryn Thompson
Extracorporeal liver support (ECLS) systems provide detoxification and synthetic function support for patients with acute liver failure and acute-on-chronic liver failure to achieve spontaneous recovery of hepatic function or to bridge to l...
Ting Feng,Jiaming Li,Xiaoyi Ma et al.
Ting Feng et al.
Traditional classifications of metabolic dysfunction-associated steatotic liver disease (MASLD) based on histology or biochemical traits are insufficient to capture this complexity and clinical strategies rely on generalized treatment appro...
Hepatosystemic T cell licensing in MASLD-associated neuroinflammation [0.03%]
与MASLD相关神经炎症中的肝系统性T细胞活化限制
Britton Spencer Cartee,Fabiola Diniz,Ravi Rai et al.
Britton Spencer Cartee et al.
"The liver is the origin of the veins and the source of the blood." - Galen, De Usu Partium Galen's hepatocentric physiology foreshadowed the liver-brain axis, a network linking vagal signaling, cytokines, metabolites, and migratory immune ...
Dilnar Mahmut,Valerie Gouon-Evans
Dilnar Mahmut
Endothelial cell dysfunction and loss are key drivers of acute and chronic liver disease, underscoring a critical unmet need for liver vascular-targeted therapies. Liver sinusoidal endothelial cells are specialized endothelial cells that fo...
Rui Ma,Haoran Meng,Xiutong Chen et al.
Rui Ma et al.
This review explores the pivotal and multifaceted roles of neutrophils in the context of liver pathophysiology. While traditionally recognized as primary effectors of antibacterial immunity, recent evidence reveals that these abundant leuko...
Feng Su,Alejandro Torres-Hernandez,Ryan Hickey et al.
Feng Su et al.
The clinical management of hepatocellular carcinoma (HCC) has evolved significantly over the past decade. Key advances include the introduction of immune-based treatment options, which now serve as the foundation for systemic therapies. Add...
Gemma Iserte,Neus Llarch,Andrew M Moon et al.
Gemma Iserte et al.
Hepatocellular carcinoma (HCC) care is rapidly evolving, driven by a relentless pursuit of improved patient outcomes, enhanced quality of life, and increased patient empowerment. This transformation draws inspiration from innovative concept...