Alcohol and liver fibrosis [0.03%]
酒精与肝纤维化
Francisco Javier Cubero,Raquel Urtasun,Natalia Nieto
Francisco Javier Cubero
Alcoholic liver disease involves significant crosstalk among intracellular signaling events in the liver. Overall, inflammatory and innate immune responses in Kupffer cells due to elevated gut-derived plasma endotoxin levels, increased reac...
Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis [0.03%]
酒精性肝炎和非酒精性脂肪肝发病机理的异同点
Wing-Kin Syn,Vanessa Teaberry,Steve S Choi et al.
Wing-Kin Syn et al.
Subpopulations of individuals with alcohol-induced fatty livers and nonalcoholic steatosis develop steatohepatitis. Steatohepatitis is defined histologically: increased numbers of injured and dying hepatocytes distinguish this condition fro...
Larry Siu,Julie Foont,Jack R Wands
Larry Siu
This review will focus on the prevalence of hepatitis c virus (HCV) infection in alcoholics with and without liver disease. Evidence will be presented to demonstrate that ethanol and chronic HCV infection synergistically accelerate liver in...
Hidekazu Tsukamoto,Keigo Machida,Alla Dynnyk et al.
Hidekazu Tsukamoto et al.
Alcoholic liver disease (ALD) is a lifestyle disease with its pathogenesis and individual predisposition governed by gene-environment interactions. Based on the "second hit" or "multiple hits" hypothesis, patients are predisposed to progres...
Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: implications for immunity [0.03%]
酒精诱导的肝实质与非实质细胞信号通路调节：对免疫的影响
Bharath Nath,Gyongyi Szabo
Bharath Nath
Alcoholic liver injury involves a complex array of derangements in cellular signaling of hepatic parenchymal and nonparenchymal cells as well as cells of the immune system. In the hepatocyte, chronic ethanol abuse leads to lipid accumulatio...
Kusum K Kharbanda
Kusum K Kharbanda
Alcoholic liver disease is a major health care problem worldwide. Findings have demonstrated that ethanol feeding impairs several of the multiple steps in methionine metabolism that leads to progressive liver injury. Ethanol consumption has...
Defeng Wu,Arthur I Cederbaum
Defeng Wu
Reactive oxygen species (ROS) are highly reactive molecules that are naturally generated in small amounts during the body's metabolic reactions and can react with and damage complex cellular molecules such as lipids, proteins, or DNA. This ...
Alcohol and liver disease [0.03%]
酒精与肝病
Natalia Osna
Natalia Osna