Nuclear receptor regulation of the adaptive response of bile acid transporters in cholestasis [0.03%]
核受体调节胆汁淤积中的胆盐转运体的适应性反应
Martin Wagner,Gernot Zollner,Michael Trauner
Martin Wagner
Although hereditary or acquired defects in hepatobiliary transporter systems cause or predispose to cholestasis, adaptive bile acid transporter changes can counteract cholestasis by reducing hepatocellular and systemic concentrations of ret...
Genetic determinants of drug-induced cholestasis and intrahepatic cholestasis of pregnancy [0.03%]
药物性肝内胆汁淤积症和妊娠期肝内胆汁淤积症的遗传决定因素
Christiane Pauli-Magnus,Peter J Meier,Bruno Stieger
Christiane Pauli-Magnus
Intrahepatic cholestasis of pregnancy and drug-induced cholestasis are two clinically important forms of acquired cholestatic liver disease. The understanding of the underlying mechanisms of acquired cholestasis has recently made considerab...
The spectrum of liver diseases related to ABCB4 gene mutations: pathophysiology and clinical aspects [0.03%]
与ABCB4基因突变相关的肝脏疾病谱系：病理生理及临床表现
Anne Davit-Spraul,Emmanuel Gonzales,Christiane Baussan et al.
Anne Davit-Spraul et al.
Class III multidrug resistance P-glycoproteins, Mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion. The role of an ABCB4 gene defect in liver disease h...
The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease [0.03%]
胆盐出口泵：遗传性和获得性胆汁淤积性肝病的临床和实验研究方面
Ping Lam,Carol J Soroka,James L Boyer
Ping Lam
The primary transporter responsible for bile salt secretion is the bile salt export pump (BSEP, ABCB11), a member of the ATP-binding cassette (ABC) superfamily, which is located at the bile canalicular apical domain of hepatocytes. In human...
Coen C Paulusma,Ronald P J Oude Elferink,Peter L M Jansen
Coen C Paulusma
Progressive familial intrahepatic cholestasis type 1 is a rare genetic liver disease that presents in the first year of life. Bile salts are elevated and these patients are often jaundiced. Despite the cholestasis, serum gamma-glutamyltrans...
James L Boyer
James L Boyer
Hepatocellular carcinoma and hepatic adenocarcinosarcoma in a patient with hepatitis B virus-related cirrhosis [0.03%]
乙型肝炎病毒相关肝硬化患者肝细胞癌和肝腺肉瘤一例报告
Qian Zhao,Chang-Qing Su,Hui Dong et al.
Qian Zhao et al.
The authors present the case of a 48-year-old man with hepatitis B cirrhosis, who developed two primary malignant liver tumors that were morphologically distinct from each other. The first tumor was a hepatocellular carcinoma and the second...
A 70-year-old woman with 10 years of markedly elevated alpha-fetoprotein measurements [0.03%]
70岁女性患者出现显著升高的甲胎蛋白指标，已达10年
Sherry X Hsu,Abby B Siegel,Paul D Berk
Sherry X Hsu
The incidence of hepatocellular carcinoma (HCC) is growing dramatically in the Western world. It is currently the fifth most common cancer worldwide, and the third most common cause of death from cancer. Studies clearly demonstrate that sur...
Nelson Fausto,Jean S Campbell
Nelson Fausto
The etiology of liver cancer is well known, but despite recent progress in the application of molecular techniques for the analysis of the development of these tumors, we still lack precise knowledge about pathogenesis of hepatocellular car...
Identification of novel oncogenes and tumor suppressors in hepatocellular carcinoma [0.03%]
肝细胞癌中新抗癌基因与肿瘤抑制基因的鉴定
Sandrine Imbeaud,Yannick Ladeiro,Jessica Zucman-Rossi
Sandrine Imbeaud
Identification of novel oncogenes and tumor suppressors in hepatocellular carcinoma (HCC) is challenging, both because of the tumor complexity and the difficulty in integrating the very large amount of data provided by different approaches....