Hypoxia: a link between fibrogenesis, angiogenesis, and carcinogenesis in liver disease [0.03%]
缺氧与肝病纤维化、血管生成和癌变之间的联系
Olivier Rosmorduc,Chantal Housset
Olivier Rosmorduc
Liver injury causes vascular disorganization and local tissue hypoxia starting early in disease course. In this context, hypoxia acts not only as an aggravating factor of cell damage and inflammation, but also as an inhibitor of liver regen...
Thomas A Wynn,Luke Barron
Thomas A Wynn
Macrophages are found in close proximity with collagen-producing myofibroblasts and indisputably play a key role in fibrosis. They produce profibrotic mediators that directly activate fibroblasts, including transforming growth factor-beta1 ...
Jean-Philippe Pradere,Juliane S Troeger,Dianne H Dapito et al.
Jean-Philippe Pradere et al.
Inflammation is strongly associated with chronic hepatic injury and the ensuing wound-healing process. Recent evidence from mouse models and human studies implicates Toll-like receptors (TLRs) as important regulators of the inflammatory res...
Cell death and fibrogenesis [0.03%]
细胞死亡与纤维化
Wajahat Mehal,Avlin Imaeda
Wajahat Mehal
Fibrosis is a common feature of chronic liver injury and is initiated by cell death inside the liver. Hepatocyte death results in apoptotic bodies and other cellular debris, which are phagocytosed by hepatic stellate cells (HSCs), resulting...
Hermann E Wasmuth,Frank Tacke,Christian Trautwein
Hermann E Wasmuth
Chemokines are a class of small chemotactic molecules with cytokine-like functions, which are well known to orchestrate inflammatory responses within different organs. Overall, more than 50 ligands and 19 receptors belong to the network. In...
D Montgomery Bissell
D Montgomery Bissell
Lawrence U Liu,Lihui Qin,A S Knisely
Lawrence U Liu
We present a patient with an initial and acute presentation of jaundice and marked persistent pruritus. Laboratory and radiology test results eliminated the possibility of acute hepatitis A/B/C viral infections, primary biliary cirrhosis, a...
Bryan L Copple,Hartmut Jaeschke,Curtis D Klaassen
Bryan L Copple
Cholestasis is a reduction in bile flow that occurs from a variety of causes in humans. This produces hepatocellular injury and fibrosis. Considering that there are limited therapies for this disease, there has been interest in understandin...
Astrid Kosters,Saul J Karpen
Astrid Kosters
Hepatobiliary transport systems are essential for the uptake and excretion of a variety of compounds including bile acids. Disruption and dysregulation of this excretory pathway result in cholestasis, leading to the intrahepatic accumulatio...
Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis [0.03%]
有机溶质转运蛋白OSTα-OSTβ在胆盐转运和胆汁淤积中的作用
Carol J Soroka,Nazzareno Ballatori,James L Boyer
Carol J Soroka
Organic solute transporter alpha-beta (OSTalpha-OSTbeta) is a unique heteromeric transporter localized to the basolateral membrane of epithelial cells involved in sterol transport. It is believed to be the primary bile acid efflux transport...