Novel insights into the pathophysiology of nonalcoholic fatty liver disease [0.03%]
非酒精性脂肪肝病病理生理的最新见解
Ariel E Feldstein
Ariel E Feldstein
Nonalcoholic fatty liver disease (NAFLD) is currently the most common form of chronic liver disease affecting both adults and children in the United States and many other parts of the world. NAFLD encompasses a wide spectrum of conditions a...
The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis [0.03%]
脂质代谢在酒精性和非酒精性脂肪肝发病机制中的作用
Margaret S Sozio,Suthat Liangpunsakul,David Crabb
Margaret S Sozio
Hepatic steatosis is now understood to play an important role in the development of advanced liver disease. Alcoholic and nonalcoholic fatty liver each begin with the accumulation of lipids in the liver. Lipid accumulation in the liver can ...
Management of chronic hepatitis B: status and challenges beyond treatment guidelines [0.03%]
慢性乙型肝炎的管理：现状和治疗指南之外的挑战
Johannes Wiegand,Florian van Bömmel,Thomas Berg
Johannes Wiegand
Several national and international guidelines have been published in the last years focusing on the problem of how to best treat patients with chronic hepatitis B virus (HBV) infection. Therapy with interferon or nucleos(t)ide analogues has...
Management of untreated and nonresponder patients with chronic hepatitis C [0.03%]
慢性丙型肝炎抗病毒治疗失败或未经治疗患者的管理策略
Leonard B Seeff,Marc G Ghany
Leonard B Seeff
Hepatitis C infection has evolved in the past quarter century from a newly recognized entity without a known pathogen (non-A, non-B hepatitis) to one of the world's most prevalent causes of liver disease, an important source for hepatocellu...
New insights into structure and replication of the hepatitis C virus and clinical implications [0.03%]
丙型肝炎病毒结构、复制新见解及其临床意义
Marion Poenisch,Ralf Bartenschlager
Marion Poenisch
With the advent of efficient systems to propagate the hepatitis C virus (HCV) in cultured cells important new discoveries have been made. For instance, several molecules required for HCV infection of hepatocytes have been identified and fir...
Hepatitis A and hepatitis C viruses: divergent infection outcomes marked by similarities in induction and evasion of interferon responses [0.03%]
肝炎A病毒和肝炎C病毒：迥异的感染结局呈现出在诱导及干扰素反应中的相似性
Lin Qu,Stanley M Lemon
Lin Qu
Hepatitis A and hepatitis C viruses (HAV and HCV) are both positive-strand ribonucleic acid (RNA) viruses with hepatotropic lifestyles. Despite several important differences, they share many biological and molecular features and similar gen...
Chronic hepatitis C of 28 years' duration characterized by early development of stage 2 (of 4) fibrosis but no significant progression over the subsequent 18 years [0.03%]
病程长达28年的慢性丙型肝炎早期即出现（分4级的）第2期肝纤维化，但其后18年进展不明显
Elizabeth C Verna,Jay H Lefkowitch,Paul D Berk
Elizabeth C Verna
A patient with chronic hepatitis B and regression of fibrosis during treatment [0.03%]
慢性乙型肝炎患者治疗期间纤维化消退的一例报告
Charissa Y Chang,Paul Martin,Anastasia Fotiadu et al.
Charissa Y Chang et al.
We present a patient with HBeAg-negative chronic hepatitis B, in whom significant regression of hepatic fibrosis was achieved after a lengthy antiviral treatment. A liver biopsy specimen obtained at initiation of treatment showed chronic he...
Silvia Curado,Didier Y R Stainier
Silvia Curado
Liver regeneration has traditionally been investigated in mammalian models. Recent technological developments in mouse genetics have greatly enhanced the resolving power of these studies. In addition, the zebrafish system has emerged as a c...
Iron homeostasis, hepatocellular injury, and fibrogenesis in hemochromatosis: the role of inflammation in a noninflammatory liver disease [0.03%]
铁稳态、肝细胞损伤和血色素沉着症中的纤维化：炎症在一个非炎性肝病中的作用
Grant A Ramm,Richard G Ruddell
Grant A Ramm
Iron is a crucially important element in normal cellular function and thus the regulation of iron homeostasis is tightly controlled. When this regulation is disrupted, for instance in hereditary hemochromatosis, abnormal intestinal absorpti...