Aftab Ala,Michael Schilsky
Aftab Ala
The genetic background of patients with liver diseases modulates hepatic injury, with some individuals being predisposed to better defenses and regenerative capacity. In this review, we focus our description of this phenomenon on inherited ...
Tom H Karlsen,Arthur Kaser
Tom H Karlsen
Genetic variants within the major histocompatibility complex (MHC) on chromosome 6 have been shown to confer risk for primary sclerosing cholangitis (PSC) ~30 years ago. However, robust genetic associations outside this genetic region have ...
Jean-Charles Nault,Jessica Zucman-Rossi
Jean-Charles Nault
Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are two leading causes of cancer death in the world. Liver carcinogenesis is driven by genetic alterations in combination with viral and environmental factors. β-catenin and P53 mu...
Marcin Krawczyk,David Q-H Wang,Piero Portincasa et al.
Marcin Krawczyk et al.
Gallstone disease affects almost 20% of individuals in Westernized countries. As its incidence in the developing countries is rising considerably, currently, it is the second most common gastroenterological condition worldwide. Gallstone fo...
Gideon M Hirschfield,Pietro Invernizzi
Gideon M Hirschfield
Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease that has a prevalence of 1 in 1000 women over the age of 40. Treatment is presently limited to ursodeoxycholic acid, a hydrophilic bile acid that has nonspecific, choler...
Quentin M Anstee,Ann K Daly,Christopher P Day
Quentin M Anstee
Excess alcohol consumption with consequent alcoholic liver disease (ALD) and metabolic syndrome-related nonalcoholic fatty liver disease (NAFLD) are recognized as the most common causes of liver dysfunction worldwide. However, although the ...
Mark Thursz,Leland Yee,Salim Khakoo
Mark Thursz
The outcome of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are heterogeneous, ranging from an asymptomatic self-limiting infection to cirrhosis and hepatocellular carcinoma. Several viral environmental and demographic var...
Tom H Karlsen,Konstantinos N Lazaridis
Tom H Karlsen
Cholangiolocellular carcinoma: an innocent-looking malignant liver tumor mimicking ductular reaction [0.03%]
胆管细胞肝癌：一种类似于胆管反应的恶性肝脏肿瘤
Christine Sempoux,Cathy Fan,Paramjeet Singh et al.
Christine Sempoux et al.
The authors present an interesting case of a 60-year-old man who underwent right hepatectomy for a diagnosis of hepatocellular carcinoma (HCC) on a background of noncirrhotic chronic hepatitis C. Pathologic examination confirmed the presenc...
Revisiting the pathology of resected benign hepatocellular nodules using new immunohistochemical markers [0.03%]
运用新的免疫组化标记物重新评估切除的良性肝细胞结节的病理性质
Paulette Bioulac-Sage,Gaelle Cubel,Charles Balabaud et al.
Paulette Bioulac-Sage et al.
In this review, the authors focus on the use of immunohistochemistry to characterize the different types and subtypes of benign hepatocellular nodules. They describe the classical and currently accepted features leading to the easy and form...