Mitochondria and Alcohol-Associated Liver Disease: Pathogenic Role and Target for Therapy [0.03%]
线粒体与酒精相关性肝病：发病机制作用及治疗靶点
Sandra Torres,Josiah Hardesty,Monica Barrios et al.
Sandra Torres et al.
Alcohol-associated liver disease (ALD) is one of the leading causes of chronic liver disease and a major cause of liver-related death. ALD is a multifactorial disease triggered by the oxidative metabolism of alcohol which leads to the activ...
Ype P de Jong
Ype P de Jong
Rodents are commonly employed to model human liver conditions, although species differences can restrict their translational relevance. To overcome some of these limitations, researchers have long pursued human hepatocyte transplantation in...
Hepatic Extracellular Matrix and Its Role in the Regulation of Liver Phenotype [0.03%]
肝细胞外基质及其在调节肝脏表型中的作用
Gavin E Arteel
Gavin E Arteel
The hepatic extracellular matrix (ECM) is most accurately depicted as a dynamic compartment that comprises a diverse range of players that work bidirectionally with hepatic cells to regulate overall homeostasis. Although the classic meaning...
You-Jin Choi,Yeonsoo Kim,Seonghwan Hwang
You-Jin Choi
This review explores the biological aspects of neutrophils, their contributions to the development of steatotic liver disease, and their potential as therapeutic targets for the disease. Although alcohol-associated and metabolic dysfunction...
Frank Lammert,Henning Wittenburg
Frank Lammert
Gallstones are common and affect up to 20% of the general adult population and >20% of them will develop symptoms or complications of cholelithiasis. The high risk of gallbladder stone formation can be reduced by ursodeoxycholic acid in the...
Maria Pilar Ballester,Esra Nur Durmazer,Tingting Qi et al.
Maria Pilar Ballester et al.
Ammonia is a product of amino acid metabolism that accumulates in the blood of patients with cirrhosis and plays a pivotal role in the pathogenesis of hepatic encephalopathy (HE). Despite being one of the main drivers of brain dysfunction, ...
Ingrid Wei Zhang,Isabella Lurje,Georg Lurje et al.
Ingrid Wei Zhang et al.
Transplantation of the liver in combination with other organs is an increasingly performed procedure. Over the years, continuous improvement in survival could be realized through careful patient selection and refined organ preservation tech...
Application of Novel Biomarkers in MASLD: Precision Medicine Based Approach [0.03%]
新型生物标志物在MASLD中应用的精准医学方法学研究
Nimish Thakral,Hailemichael Desalegn,Luis Antonio Diaz et al.
Nimish Thakral et al.
The new nomenclature of metabolic dysfunction-associated steatotic liver disease (MASLD) emphasizes a positive diagnosis based on cardiometabolic risk factors (CMRFs). This definition is not only less stigmatizing but also allows for subcla...
Noninvasive Tests to Assess Fibrosis and Disease Severity in Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic-Dysfunction-Associated Steatohepatitis [0.03%]
评估代谢异常相关肝脂肪变性及其炎症性疾病纤维化和病情严重程度的无创检测方法
Monica A Tincopa,Rohit Loomba
Monica A Tincopa
Risk of disease progression and clinical outcomes in metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with fibrosis stage and presence of "at-risk metabolic dysfunction-associated steatohepatitis (MASH)." Altho...
Cheng Chen,Dechun Feng,Yang Wang et al.
Cheng Chen et al.
The liver has the great ability to regenerate after partial resection or injury, and the mechanisms underlying liver regeneration have been extensively investigated. Interestingly, acute liver injuries triggered by various etiologies are as...