Enrico Pompili,Giulia Iannone,Daniele Carrello et al.
Enrico Pompili et al.
Acute-on-chronic liver failure (ACLF) is defined as a clinical syndrome that develops in patients with chronic liver disease characterized by the presence of organ failure and high short-term mortality, although there is still no worldwide ...
Lung-Yi Mak,Tobias Boettler,Upkar S Gill
Lung-Yi Mak
Over 300 million individuals worldwide are chronically infected with hepatitis B virus and at risk for progressive liver disease. Due to the lack of a therapy that reliably achieves viral elimination and the variability of liver disease pro...
Therapeutic Potential of Nutraceuticals against Drug-Induced Liver Injury [0.03%]
营养补充剂防治药物性肝损伤的潜在价值
Namya Sethi,Manoj Khokhar,Mitali Mathur et al.
Namya Sethi et al.
Drug-induced liver injury (DILI) continues to be a major concern in clinical practice, thus necessitating a need for novel therapeutic approaches to alleviate its impact on hepatic function. This review investigates the therapeutic potentia...
Role of the Gut Microbiome in Metabolic Dysfunction-Associated Steatotic Liver Disease [0.03%]
肠道微生物组在代谢功能异常性脂肪肝病中的作用
Salim Maher,Jayashi Rajapakse,Emad El-Omar et al.
Salim Maher et al.
The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD)-previously described as nonalcoholic fatty liver disease-continues to rise globally. Despite this, therapeutic measures for MASLD remain limited. Recently, t...
Patient-Reported Outcomes in Metabolic Dysfunction-Associated Steatotic Liver Disease [0.03%]
与代谢紊乱相关肝脂肪变性疾病的患者报告结果
Aurora Barberá,Trenton M White,Anish K Arora et al.
Aurora Barberá et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and can progress to serious complications, including metabolic dysfunction-associated steatohepatitis (MASH), cirrhosis, end...
Babu Lal Meena,Shiv Kumar Sarin
Babu Lal Meena
Portal vein thrombosis (PVT) is one of the common complications of cirrhosis. The incidence of PVT correlates with liver disease severity-higher incidence in patients with Child-Turcotte-Pugh (CTP) C, large spontaneous portosystemic shunts,...
Mitochondria and Alcohol-Associated Liver Disease: Pathogenic Role and Target for Therapy [0.03%]
线粒体与酒精相关性肝病：发病机制作用及治疗靶点
Sandra Torres,Josiah Hardesty,Monica Barrios et al.
Sandra Torres et al.
Alcohol-associated liver disease (ALD) is one of the leading causes of chronic liver disease and a major cause of liver-related death. ALD is a multifactorial disease triggered by the oxidative metabolism of alcohol which leads to the activ...
Ype P de Jong
Ype P de Jong
Rodents are commonly employed to model human liver conditions, although species differences can restrict their translational relevance. To overcome some of these limitations, researchers have long pursued human hepatocyte transplantation in...
Hepatic Extracellular Matrix and Its Role in the Regulation of Liver Phenotype [0.03%]
肝细胞外基质及其在调节肝脏表型中的作用
Gavin E Arteel
Gavin E Arteel
The hepatic extracellular matrix (ECM) is most accurately depicted as a dynamic compartment that comprises a diverse range of players that work bidirectionally with hepatic cells to regulate overall homeostasis. Although the classic meaning...
You-Jin Choi,Yeonsoo Kim,Seonghwan Hwang
You-Jin Choi
This review explores the biological aspects of neutrophils, their contributions to the development of steatotic liver disease, and their potential as therapeutic targets for the disease. Although alcohol-associated and metabolic dysfunction...