Peter F Whitington
Peter F Whitington
Neonatal hemochromatosis (NH) is a clinical syndrome consisting of liver disease and pathologic siderosis of various extrahepatic tissues. NH is a form of secondary hemochromatosis in which severe fetal liver injury causes iron overload due...
A critical appraisal of advances in pediatric nonalcoholic Fatty liver disease [0.03%]
儿科非酒精性脂肪肝病进展的批判性评价
Nadia Ovchinsky,Joel E Lavine
Nadia Ovchinsky
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease in children; its rise has been related to the increasing prevalence of obesity. Significant advancements have been made in the investigation of the etiopatho...
Cara L Mack,Amy G Feldman,Ronald J Sokol
Cara L Mack
Biliary atresia (BA) is an infantile obstructive cholangiopathy of unknown etiology with suboptimal therapy, which is responsible for 40 to 50% of all pediatric liver transplants. Although the etiology of bile duct injury in BA in unknown, ...
Using human-induced pluripotent stem cells to model monogenic metabolic disorders of the liver [0.03%]
利用人类诱导多能干细胞模拟肝脏单基因代谢障碍性疾病
Maria Paulina Ordonez,Lawrence S B Goldstein
Maria Paulina Ordonez
A crucial problem in liver disease biology and a major obstacle to the development of new therapies is the inability to conduct mechanistic studies of live human hepatocytes. Liver tissue from patients is difficult to obtain and only reveal...
Advances in the evaluation and management of children with portal hypertension [0.03%]
儿童门静脉高压症的评估和治疗进展
Simon C Ling
Simon C Ling
Portal hypertension commonly accompanies advanced liver disease and gives rise to severe and life-threatening complications, including hemorrhage from esophageal varices. Diagnosis of portal hypertension in children currently relies on find...
Congenital portosystemic shunts in children: recognition, evaluation, and management [0.03%]
儿童先天性门体分流的识别、评估和处理措施
O Bernard,S Franchi-Abella,S Branchereau et al.
O Bernard et al.
Congenital portosystemic shunts are present in one in 30,000 children. Among the associated risks of severe complications are neonatal cholestasis, benign and malignant liver tumors, hepatopulmonary syndrome, portopulmonary hypertension, an...
Pediatric liver diseases [0.03%]
儿科肝病学杂志
Joel E Lavine
Joel E Lavine
Paul D Berk
Paul D Berk
A case of quadruple viral infections and elevated aminotransferase activities [0.03%]
四联病毒感染和转氨酶活性升高的病例报告
Devina Bhasin,Xuchen Zhang,Stephen C Ward et al.
Devina Bhasin et al.
A 40-year-old man with human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus (HBV) infection was referred for evaluation of abnormal liver enzyme activities. The patient was maintained on antiretroviral therapy ...
Michael Roggendorf
Michael Roggendorf
Hepatitis delta virus (HDV) causes severe hepatitis in carriers of hepatitis B virus (HBV). In ~90% of patients, HDV persists together with HBV and causes early development of cirrhosis and liver carcinoma. Worldwide ~15 million people are ...