Peng Cao,Hartmut Jaeschke,Hong-Min Ni et al.
Peng Cao et al.
Liver diseases are closely associated with various cell death mechanisms, including apoptosis, necroptosis, autophagy, pyroptosis, and ferroptosis. Each process contributes uniquely to the pathophysiology of liver injury and repair. Importa...
Wagner Ramírez-Quesada,Edilmar Alvarado-Tapias,Sarah Shalaby et al.
Wagner Ramírez-Quesada et al.
The onset of decompensation in advanced chronic liver disease (ACLD) is a hallmark in natural history, with a poor prognosis and a significantly increased liver-related mortality. Etiological treatments for viral hepatitis or abstinence in ...
Understanding and Treating Hepatorenal Syndrome: Insights from Recent Research [0.03%]
肝肾综合征的诊治研究进展及启示
Yuli Song,Xiaochen Yang,Chengbo Yu
Yuli Song
Acute kidney injury (AKI) is a critical and often fatal complication in decompensated cirrhosis, significantly affecting inpatient survival rates. Hepatorenal syndrome (HRS), a distinct subtype of AKI, develops in individuals with advanced ...
Tao Liu,FeiYu Zhang,Yue Feng et al.
Tao Liu et al.
Alcohol is generally believed to be metabolized in the liver by alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and to a much lesser extent cytochrome P450 2E1 (CYP2E1) and other enzymes. Recent studies suggest that gut also pla...
Primary Cilia in Hepatic Biliary Hyperplasia: Implications for Liver Diseases [0.03%]
肝胆管增生中的初级纤毛：对肝脏疾病的影响
Kishor Pant,Estanislao Peixoto,Sergio A Gradilone
Kishor Pant
Primary cilia, hair-like projections on the surface of various cell types, play crucial roles in sensing and regulating environmental cues within the liver, particularly among cholangiocytes. These structures detect changes in bile composit...
Juliane I Beier,Jianzhu Luo,Charis-Marie Vanderpuye et al.
Juliane I Beier et al.
Environmental pollutants significantly impact liver disease development, progression, and outcomes. This review examines the complex relationship between environmental exposures and liver pathology, from malignant conditions like hepatocell...
Moira B Hilscher,Jonathan Johnson
Moira B Hilscher
Fontan associated liver disease (FALD) occurs in all patients who have undergone Fontan palliative repair for functional single ventricle congenital heart defects. While liver fibrosis is universal in patients who have undergone Fontan repa...
Role of Intestinal Barrier Disruption to Acute-on-Chronic Liver Failure [0.03%]
肠道屏障功能破坏在急性加重的慢性肝功能不全中的作用
Julian Pohl,Dimitrios Aretakis,Frank Tacke et al.
Julian Pohl et al.
Acute-on-chronic liver failure (ACLF) is a severe condition in patients with decompensated liver cirrhosis, marked by high short-term mortality. Recent experimental and clinical evidence has linked intestinal dysfunction to both the initiat...
Laura Sererols-Viñas,Gemma Garcia-Vicién,Paloma Ruiz-Blázquez et al.
Laura Sererols-Viñas et al.
Hepatic stellate cells (HSCs) are the liver's pericytes, and play key roles in liver homeostasis, regeneration, fibrosis and cancer. Upon injury, HSCs activate and are the main origin of myofibroblasts and cancer associated fibroblasts (CAF...
PATHOGENESIS AND MANAGEMENT OF INTESTINAL FAILURE-ASSOCIATED LIVER DISEASE [0.03%]
肠功能衰竭相关肝病的发病机制和处理方法
Sasha-Jane Abi-Aad,Mark Lovell,Racha Khalaf et al.
Sasha-Jane Abi-Aad et al.
Long-term parenteral nutrition (PN) has considerably improved the management of intestinal failure (IF) in children and adults, particularly those with short bowel syndrome; however, it carries a significant risk of hepatotoxicity, specific...