Big Data Analytics in Large Cohorts: Opportunities and Challenges for Research in Hepatology [0.03%]
大数据在大型队列中的分析：肝病学研究的机会与挑战
Helen Ye Rim Huang,Kai Markus Schneider,Carolin Schneider
Helen Ye Rim Huang
Advances in big data analytics, precision medicine, and artificial intelligence are transforming hepatology, offering new insights into disease mechanisms, risk stratification, and therapeutic interventions. In this review, we explore how t...
IgG4-Related Cholangitis [0.03%]
IgG4相关的胆管炎
Ulrich Beuers,David C Trampert
Ulrich Beuers
IgG4-related cholangitis (IRC) is a rare fibroinflammatory disease of the biliary tree and liver and presents the major hepatobiliary manifestation of IgG4-related systemic disease (IgG4-RD). IRC also includes the IgG4-related inflammatory ...
Liver Neurobiology: Regulation of Liver Functions by the Nervous System [0.03%]
肝脏神经生物学：神经系统对肝功能的调节作用
Boris Mravec,Maria Szantova
Boris Mravec
The nervous system plays an important role in the regulation of liver functions during physiological as well as pathological conditions. This regulatory effect is based on the processing of signals transmitted to the brain by sensory nerves...
Huanli Jiao,Han Wang,Jia Li et al.
Huanli Jiao et al.
Cirrhosis is an important cause of morbidity and death in patients with chronic liver disease. It can be divided into compensatory and decompensated stages. During the decompensation period, complications such as esophageal and gastric vari...
Peng Cao,Hartmut Jaeschke,Hong-Min Ni et al.
Peng Cao et al.
Liver diseases are closely associated with various cell death mechanisms, including apoptosis, necroptosis, autophagy, pyroptosis, and ferroptosis. Each process contributes uniquely to the pathophysiology of liver injury and repair. Importa...
Wagner Ramírez-Quesada,Edilmar Alvarado-Tapias,Sarah Shalaby et al.
Wagner Ramírez-Quesada et al.
The onset of decompensation in advanced chronic liver disease (ACLD) is a hallmark in natural history, with a poor prognosis and a significantly increased liver-related mortality. Etiological treatments for viral hepatitis or abstinence in ...
Understanding and Treating Hepatorenal Syndrome: Insights from Recent Research [0.03%]
肝肾综合征的诊治研究进展及启示
Yuli Song,Xiaochen Yang,Chengbo Yu
Yuli Song
Acute kidney injury (AKI) is a critical and often fatal complication in decompensated cirrhosis, significantly affecting inpatient survival rates. Hepatorenal syndrome (HRS), a distinct subtype of AKI, develops in individuals with advanced ...
Tao Liu,FeiYu Zhang,Yue Feng et al.
Tao Liu et al.
Alcohol is generally believed to be metabolized in the liver by alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and to a much lesser extent cytochrome P450 2E1 (CYP2E1) and other enzymes. Recent studies suggest that gut also pla...
Primary Cilia in Hepatic Biliary Hyperplasia: Implications for Liver Diseases [0.03%]
肝胆管增生中的初级纤毛：对肝脏疾病的影响
Kishor Pant,Estanislao Peixoto,Sergio A Gradilone
Kishor Pant
Primary cilia, hair-like projections on the surface of various cell types, play crucial roles in sensing and regulating environmental cues within the liver, particularly among cholangiocytes. These structures detect changes in bile composit...
Juliane I Beier,Jianzhu Luo,Charis-Marie Vanderpuye et al.
Juliane I Beier et al.
Environmental pollutants significantly impact liver disease development, progression, and outcomes. This review examines the complex relationship between environmental exposures and liver pathology, from malignant conditions like hepatocell...