Integrated Patient Digital and Biomimetic Twins for Precision Medicine: A Perspective [0.03%]
用于精准医疗的集成化患者数字孪生和生物仿生孪生：展望论文
Mark T Miedel,Mark E Schurdak,Andrew M Stern et al.
Mark T Miedel et al.
A new paradigm for drug development and patient therapeutic strategies is required, especially for complex, heterogeneous diseases including metabolic dysfunction-associated steatotic liver disease (MASLD). Heterogeneity in MASLD patients i...
Souradipta Ganguly,Sadatsugu Sakane,Kanani Hokutan et al.
Souradipta Ganguly et al.
Aging is characterized by the progressive deterioration of cell and tissue functions. The liver, which regulates metabolic homeostasis, detoxification, and immune responses, undergoes structural and functional changes with age. These includ...
Sarah Shalaby,Wagner Enrique Ramírez-Quesada,Asunción Ojeda et al.
Sarah Shalaby et al.
Portosinusoidal vascular disorders (PSVD) represent a group of rare conditions characterized by abnormalities in the liver's vascular architecture, often manifesting with clinical features of portal hypertension (PH), in the absence of cirr...
Preface (Introduction): Metabolic Liver Disease: A New Era in Hepatology [0.03%]
序言（前言）：代谢性肝病：肝病学的新时代
Ashwani K Singal
Ashwani K Singal
Mads Israelsen,Eric Trépo,Aleksander Krag et al.
Mads Israelsen et al.
Metabolic and alcohol-related liver disease (MetALD) is a subcategory of steatotic liver disease (SLD) characterized by the coexistence of cardiometabolic risk factors and elevated alcohol intake. The global prevalence of MetALD is estimate...
Elisabeth Tatscher,Samy Mady,Peter Fickert
Elisabeth Tatscher
Primary sclerosing cholangitis (PSC) is a rare, progressive cholestatic disease of unknown etiology and characterized by inflammation and stricturing of intrahepatic and/or extrahepatic bile ducts. This process leads to bile duct scarring, ...
Big Data Analytics in Large Cohorts: Opportunities and Challenges for Research in Hepatology [0.03%]
大数据在大型队列中的分析：肝病学研究的机会与挑战
Helen Ye Rim Huang,Kai Markus Schneider,Carolin Schneider
Helen Ye Rim Huang
Advances in big data analytics, precision medicine, and artificial intelligence are transforming hepatology, offering new insights into disease mechanisms, risk stratification, and therapeutic interventions. In this review, we explore how t...
IgG4-Related Cholangitis [0.03%]
IgG4相关的胆管炎
Ulrich Beuers,David C Trampert
Ulrich Beuers
IgG4-related cholangitis (IRC) is a rare fibroinflammatory disease of the biliary tree and liver and presents the major hepatobiliary manifestation of IgG4-related systemic disease (IgG4-RD). IRC also includes the IgG4-related inflammatory ...
Liver Neurobiology: Regulation of Liver Functions by the Nervous System [0.03%]
肝脏神经生物学：神经系统对肝功能的调节作用
Boris Mravec,Maria Szantova
Boris Mravec
The nervous system plays an important role in the regulation of liver functions during physiological as well as pathological conditions. This regulatory effect is based on the processing of signals transmitted to the brain by sensory nerves...
Huanli Jiao,Han Wang,Jia Li et al.
Huanli Jiao et al.
Cirrhosis is an important cause of morbidity and death in patients with chronic liver disease. It can be divided into compensatory and decompensated stages. During the decompensation period, complications such as esophageal and gastric vari...