Patient-derived models of liver cancer to inform therapeutic decision: recent updates [0.03%]
肝癌患者衍生模型的治疗决策：最新进展
Kelley Weinfurtner,Rudra Amin,Nicholas Skuli et al.
Kelley Weinfurtner et al.
Primary liver cancer remains a global health challenge due to rising incidence, limited curative options, and poor overall survival. Poor outcomes stem from tumor heterogeneity, limited efficacy of current therapies, and co-morbid chronic l...
Vinay Jahagirdar,Elina Stoffel,Kaanthi Rama et al.
Vinay Jahagirdar et al.
Aina Anton,Scott Laurence Friedman,Bruno Cogliati
Aina Anton
Primary liver cancer, or hepatocellular carcinoma (HCC), typically emerges in fibrotic livers where persistent inflammation and extracellular matrix (ECM) remodeling create a permissive niche for malignant transformation. Although cirrhosis...
Nutrition and Liver Disease [0.03%]
营养与肝病
Allison Franz,Henry Shay,Irina Kirpich et al.
Allison Franz et al.
The liver is a dynamic organ that plays a central role in metabolism and serves several critical functions in maintaining overall nutritional health, including helping maintain metabolic homeostasis by ensuring energy needs are met, elimina...
Hanna Blaney,Adelina Horhat,Abdulmalik Saleem et al.
Hanna Blaney et al.
Alcohol-associated liver disease (ALD) is a leading cause of liver disease worldwide, caused by hazardous alcohol use. Many patients with ALD also have alcohol use disorder (AUD), a chronic mental health condition characterized by a cluster...
Combined hepatocellular-cholangiocarcinoma: a clinical and molecular review [0.03%]
肝细胞癌与胆管癌的临床和分子特征综述
Shaodian Xu,Julien Calderaro
Shaodian Xu
Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver malignancy characterized by the coexistence of both hepatocellular and biliary morphological differentiation. It is thought to represent less than 5% of all prima...
Thomas J Wang,Ajaypal Singh
Thomas J Wang
Endohepatology is an emerging field that encompasses various diagnostic and therapeutic endoscopic ultrasound (EUS) techniques for the management of liver disease. It encompasses diagnostic techniques for fibrosis staging and portal hyperte...
Microbial Modulation of the Gut-Liver Axis in Autoimmune Liver Diseases [0.03%]
肠道菌群调控自身免疫性肝病中的肠肝轴作用
Shihui Wei,Juan Lu
Shihui Wei
Autoimmune liver diseases (AILDs), including autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis, are chronic inflammatory conditions influenced by complex interactions among genetic, environmental, and imm...
Oluwashanu Balogun,Kari Nejak-Bowen
Oluwashanu Balogun
The porphyrias are a group of metabolic disorders that are caused by defects in one of the eight enzymes that synthesize heme. A common feature of all porphyrias is accumulation of porphyrin precursors or porphyrins, which are intermediates...
Ammar Hassan,Elliot Tapper
Ammar Hassan
Patient centered care for chronic liver disease is an approach that supports patient engagement and proactive interventions aimed at preserving quality of life and function and preventing adverse outcomes. Patient centered care is fully rea...