Thomas J Wang,Ajaypal Singh
Thomas J Wang
Endohepatology is an emerging field that encompasses various diagnostic and therapeutic endoscopic ultrasound (EUS) techniques for the management of liver disease. It encompasses diagnostic techniques for fibrosis staging and portal hyperte...
Microbial Modulation of the Gut-Liver Axis in Autoimmune Liver Diseases [0.03%]
肠道菌群调控自身免疫性肝病中的肠肝轴作用
Shihui Wei,Juan Lu
Shihui Wei
Autoimmune liver diseases (AILDs), including autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis, are chronic inflammatory conditions influenced by complex interactions among genetic, environmental, and imm...
Oluwashanu Balogun,Kari Nejak-Bowen
Oluwashanu Balogun
The porphyrias are a group of metabolic disorders that are caused by defects in one of the eight enzymes that synthesize heme. A common feature of all porphyrias is accumulation of porphyrin precursors or porphyrins, which are intermediates...
Ammar Hassan,Elliot Tapper
Ammar Hassan
Patient centered care for chronic liver disease is an approach that supports patient engagement and proactive interventions aimed at preserving quality of life and function and preventing adverse outcomes. Patient centered care is fully rea...
Integrated Patient Digital and Biomimetic Twins for Precision Medicine: A Perspective [0.03%]
用于精准医疗的集成化患者数字孪生和生物仿生孪生：展望论文
Mark T Miedel,Mark E Schurdak,Andrew M Stern et al.
Mark T Miedel et al.
A new paradigm for drug development and patient therapeutic strategies is required, especially for complex, heterogeneous diseases including metabolic dysfunction-associated steatotic liver disease (MASLD). Heterogeneity in MASLD patients i...
Souradipta Ganguly,Sadatsugu Sakane,Kanani Hokutan et al.
Souradipta Ganguly et al.
Aging is characterized by the progressive deterioration of cell and tissue functions. The liver, which regulates metabolic homeostasis, detoxification, and immune responses, undergoes structural and functional changes with age. These includ...
Sarah Shalaby,Wagner Enrique Ramírez-Quesada,Asunción Ojeda et al.
Sarah Shalaby et al.
Portosinusoidal vascular disorders (PSVD) represent a group of rare conditions characterized by abnormalities in the liver's vascular architecture, often manifesting with clinical features of portal hypertension (PH), in the absence of cirr...
Preface (Introduction): Metabolic Liver Disease: A New Era in Hepatology [0.03%]
序言（前言）：代谢性肝病：肝病学的新时代
Ashwani K Singal
Ashwani K Singal
Mads Israelsen,Eric Trépo,Aleksander Krag et al.
Mads Israelsen et al.
Metabolic and alcohol-related liver disease (MetALD) is a subcategory of steatotic liver disease (SLD) characterized by the coexistence of cardiometabolic risk factors and elevated alcohol intake. The global prevalence of MetALD is estimate...
Elisabeth Tatscher,Samy Mady,Peter Fickert
Elisabeth Tatscher
Primary sclerosing cholangitis (PSC) is a rare, progressive cholestatic disease of unknown etiology and characterized by inflammation and stricturing of intrahepatic and/or extrahepatic bile ducts. This process leads to bile duct scarring, ...