Genetic Contributions to Biliary Atresia: A Developmental Cholangiopathy [0.03%]
遗传因素在胆道闭锁中的作用：一种发育性胆管病
Dominick J Hellen,Saul J Karpen
Dominick J Hellen
Biliary atresia (BA) is the most prevalent serious liver disease of infancy and childhood, and the principal indication for liver transplantation in pediatrics. BA is best considered as an idiopathic panbiliary cholangiopathy characterized ...
Tannaz Ranjbarian,Bernd Schnabl
Tannaz Ranjbarian
Globally, liver disease caused by alcohol is becoming more prevalent each year. Misuse of alcohol causes a spectrum of liver diseases, such as liver steatosis, steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. The cornerst...
Brian Pearlman
Brian Pearlman
First discovered over 40 years ago, the hepatitis delta virus (HDV) is a unique RNA virus, requiring hepatitis B virus (HBV) antigens for its assembly, replication, and transmission. HBV and HDV can be acquired at the same time (coinfection...
Kshitij Deshmukh,Udayan Apte
Kshitij Deshmukh
Exposure to hepatotoxic chemicals is involved in liver disease-related morbidity and mortality worldwide. The liver responds to damage by triggering compensatory hepatic regeneration. Physical agent or chemical-induced liver damage disrupts...
Vik Meadows,Zhenning Yang,Veronia Basaly et al.
Vik Meadows et al.
Chronic liver diseases encompass a wide spectrum of hepatic maladies that often result in cholestasis or altered bile acid secretion and regulation. Incidence and cost of care for many chronic liver diseases are rising in the United States ...
Shawna A Cooper,Enis Kostallari,Vijay H Shah
Shawna A Cooper
Liver sinusoidal endothelial cells (LSECs) are key players in maintaining hepatic homeostasis. They also play crucial roles during liver injury by communicating with liver cell types as well as immune cells and promoting portal hypertension...
How to Identify Advanced Nonalcoholic Fatty Liver Disease in the Primary Care Setting [0.03%]
如何在初级保健环境中识别非酒精性脂肪肝病的晚期阶段
Pegah Golabi,Dipam Shah,Zobair M Younossi
Pegah Golabi
Nonalcoholic fatty liver disease (NAFLD) affects 30 to 40% of the population globally and is increasingly considered the most common liver disease. Patients with type 2 diabetes, obesity, and cardiovascular diseases are at especially increa...
Mathias Ruiz,Florence Lacaille,Christina Schrader et al.
Mathias Ruiz et al.
Alpha-1 antitrypsin deficiency (AATD) arises due to inherited variants in SERPINA1, the AAT gene that impairs the production or secretion of this hepatocellular protein and leads to a gain-of-function liver proteotoxicity. Homozygous Pi*Z p...
Critical Care Management of Acute-on-Chronic Liver Failure: Certainties and Unknowns [0.03%]
急性肝衰竭并慢性肝病的重症监护：明确之处与未知之域
Enric Reverter,David Toapanta,Octavi Bassegoda et al.
Enric Reverter et al.
Intensive care unit (ICU) admission is frequently required in patients with decompensated cirrhosis for organ support. This entity, known as acute-on-chronic liver failure (ACLF), is associated with high short-term mortality. ICU management...
To TIPS or Not to TIPS in High Risk of Variceal Rebleeding and Acute-on-Chronic Liver Failure [0.03%]
对于急性-慢性肝功能衰竭和食管静脉曲张再出血高风险患者进行TIPS治疗吗？
Wenyi Gu,Markus Kimmann,Wim Laleman et al.
Wenyi Gu et al.
Variceal bleeding is a consequence of severe portal hypertension in patients with liver cirrhosis. Although the rate of bleeding has decreased over time, variceal bleeding in the presence of acute-on-chronic liver failure (ACLF) carries a h...