Sierra R Wilson,Andrew W Duncan
Sierra R Wilson
The liver's unique chromosomal variations, including polyploidy and aneuploidy, influence hepatocyte identity and function. Among the most well-studied mammalian polyploid cells, hepatocytes exhibit a dynamic interplay between diploid and p...
Fátima Manzano-Núñez,Lara Prates Tiago Aguilar,Christine Sempoux et al.
Fátima Manzano-Núñez et al.
Biliary tract cancer is a devastating malignancy of the bile ducts and gallbladder with a dismal prognosis. The study of precancerous lesions has received considerable attention and led to a histopathological classification which, in some r...
Unraveling the Complexities of Immune Checkpoint Inhibitors in Hepatocellular Carcinoma [0.03%]
肝细胞癌免疫检查点抑制剂治疗的复杂性解析
Xinpu Han,Qianhui Sun,Manman Xu et al.
Xinpu Han et al.
Immune checkpoint inhibitors (ICIs) have emerged as effective therapeutics for multiple cancers. Nevertheless, as immunotherapeutic approaches are being extensively utilized, substantial hurdles have arisen for clinicians. These include cou...
Erratum to: Genetic Contributions to Biliary Atresia: A Developmental Cholangiopathy [0.03%]
遗传因素对胆道闭锁的贡献：一种发育性胆管疾病
Dominick J Hellen,Saul J Karpen
Dominick J Hellen
Published Erratum
Seminars in liver disease. 2023 Aug;43(3):e2. DOI:10.1055/s-0043-1776036 2023
Brian Pearlman
Brian Pearlman
Published Erratum
Seminars in liver disease. 2023 Aug;43(3):e1. DOI:10.1055/s-0043-1776037 2023
Rajesh Kumar Dutta,JiHye Jun,Kuo Du et al.
Rajesh Kumar Dutta et al.
The purpose of this review is to summarize current knowledge about the role of the Hedgehog signaling pathway in liver homeostasis and disease. Hedgehog is a morphogenic signaling pathway that is active in development. In most healthy tissu...
Mechanisms of Lipid Droplet Accumulation in Steatotic Liver Diseases [0.03%]
脂质 droplets在肝脂肪变性疾病中累积的机制
Joseph L Dempsey,George N Ioannou,Rotonya M Carr
Joseph L Dempsey
The steatotic diseases of metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-associated liver disease (ALD), and chronic hepatitis C (HCV) account for the majority of liver disease prevalence, morbidity, and mortality...
Alcohol-Related Liver Disease: Is There a Safe Alcohol Consumption Limit for Liver Disease? [0.03%]
饮酒相关肝病：肝病患者安全的饮酒量限度是多少？
Katrina Pekarska,Richard Parker
Katrina Pekarska
This review is to evaluate how much alcohol is safe in the context of alcohol-related liver disease (ALD). In patients without an established diagnosis of ALD consuming alcohol at quantities below 12 to 20 g daily with alcohol-free days is ...
Kai Zhu,Olivia Tsai,Daljeet Chahal et al.
Kai Zhu et al.
The COVID-19 pandemic has resulted in significant worldwide morbidity and mortality. In this review, we examine the intricate relationships between COVID-19 and liver diseases. While respiratory manifestations of COVID-19 are well known, it...
Baoyi Jiang,Yulin Zhou,Yanting Liu et al.
Baoyi Jiang et al.
Cytokines are important components of the immune system that can predict or influence the development of liver diseases. IL-37, a new member of the IL-1 cytokine family, exerts potent anti-inflammatory and immunosuppressive effects inside a...