Mechanisms of Lipid Droplet Accumulation in Steatotic Liver Diseases [0.03%]
脂质 droplets在肝脂肪变性疾病中累积的机制
Joseph L Dempsey,George N Ioannou,Rotonya M Carr
Joseph L Dempsey
The steatotic diseases of metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-associated liver disease (ALD), and chronic hepatitis C (HCV) account for the majority of liver disease prevalence, morbidity, and mortality...
Alcohol-Related Liver Disease: Is There a Safe Alcohol Consumption Limit for Liver Disease? [0.03%]
饮酒相关肝病：肝病患者安全的饮酒量限度是多少？
Katrina Pekarska,Richard Parker
Katrina Pekarska
This review is to evaluate how much alcohol is safe in the context of alcohol-related liver disease (ALD). In patients without an established diagnosis of ALD consuming alcohol at quantities below 12 to 20 g daily with alcohol-free days is ...
Kai Zhu,Olivia Tsai,Daljeet Chahal et al.
Kai Zhu et al.
The COVID-19 pandemic has resulted in significant worldwide morbidity and mortality. In this review, we examine the intricate relationships between COVID-19 and liver diseases. While respiratory manifestations of COVID-19 are well known, it...
Baoyi Jiang,Yulin Zhou,Yanting Liu et al.
Baoyi Jiang et al.
Cytokines are important components of the immune system that can predict or influence the development of liver diseases. IL-37, a new member of the IL-1 cytokine family, exerts potent anti-inflammatory and immunosuppressive effects inside a...
Genetic Contributions to Biliary Atresia: A Developmental Cholangiopathy [0.03%]
遗传因素在胆道闭锁中的作用：一种发育性胆管病
Dominick J Hellen,Saul J Karpen
Dominick J Hellen
Biliary atresia (BA) is the most prevalent serious liver disease of infancy and childhood, and the principal indication for liver transplantation in pediatrics. BA is best considered as an idiopathic panbiliary cholangiopathy characterized ...
Tannaz Ranjbarian,Bernd Schnabl
Tannaz Ranjbarian
Globally, liver disease caused by alcohol is becoming more prevalent each year. Misuse of alcohol causes a spectrum of liver diseases, such as liver steatosis, steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. The cornerst...
Brian Pearlman
Brian Pearlman
First discovered over 40 years ago, the hepatitis delta virus (HDV) is a unique RNA virus, requiring hepatitis B virus (HBV) antigens for its assembly, replication, and transmission. HBV and HDV can be acquired at the same time (coinfection...
Kshitij Deshmukh,Udayan Apte
Kshitij Deshmukh
Exposure to hepatotoxic chemicals is involved in liver disease-related morbidity and mortality worldwide. The liver responds to damage by triggering compensatory hepatic regeneration. Physical agent or chemical-induced liver damage disrupts...
Vik Meadows,Zhenning Yang,Veronia Basaly et al.
Vik Meadows et al.
Chronic liver diseases encompass a wide spectrum of hepatic maladies that often result in cholestasis or altered bile acid secretion and regulation. Incidence and cost of care for many chronic liver diseases are rising in the United States ...
Shawna A Cooper,Enis Kostallari,Vijay H Shah
Shawna A Cooper
Liver sinusoidal endothelial cells (LSECs) are key players in maintaining hepatic homeostasis. They also play crucial roles during liver injury by communicating with liver cell types as well as immune cells and promoting portal hypertension...