Dilnar Mahmut,Valerie Gouon-Evans
Dilnar Mahmut
Endothelial cell dysfunction and loss are key drivers of acute and chronic liver disease, underscoring a critical unmet need for liver vascular-targeted therapies. Liver sinusoidal endothelial cells are specialized endothelial cells that fo...
Rui Ma,Haoran Meng,Xiutong Chen et al.
Rui Ma et al.
This review explores the pivotal and multifaceted roles of neutrophils in the context of liver pathophysiology. While traditionally recognized as primary effectors of antibacterial immunity, recent evidence reveals that these abundant leuko...
Feng Su,Alejandro Torres-Hernandez,Ryan Hickey et al.
Feng Su et al.
The clinical management of hepatocellular carcinoma (HCC) has evolved significantly over the past decade. Key advances include the introduction of immune-based treatment options, which now serve as the foundation for systemic therapies. Add...
Gemma Iserte,Neus Llarch,Andrew M Moon et al.
Gemma Iserte et al.
Hepatocellular carcinoma (HCC) care is rapidly evolving, driven by a relentless pursuit of improved patient outcomes, enhanced quality of life, and increased patient empowerment. This transformation draws inspiration from innovative concept...
Patient-derived models of liver cancer to inform therapeutic decision: recent updates [0.03%]
肝癌患者衍生模型的治疗决策：最新进展
Kelley Weinfurtner,Rudra Amin,Nicholas Skuli et al.
Kelley Weinfurtner et al.
Primary liver cancer remains a global health challenge due to rising incidence, limited curative options, and poor overall survival. Poor outcomes stem from tumor heterogeneity, limited efficacy of current therapies, and co-morbid chronic l...
Vinay Jahagirdar,Elina Stoffel,Kaanthi Rama et al.
Vinay Jahagirdar et al.
Aina Anton,Scott Laurence Friedman,Bruno Cogliati
Aina Anton
Primary liver cancer, or hepatocellular carcinoma (HCC), typically emerges in fibrotic livers where persistent inflammation and extracellular matrix (ECM) remodeling create a permissive niche for malignant transformation. Although cirrhosis...
Nutrition and Liver Disease [0.03%]
营养与肝病
Allison Franz,Henry Shay,Irina Kirpich et al.
Allison Franz et al.
The liver is a dynamic organ that plays a central role in metabolism and serves several critical functions in maintaining overall nutritional health, including helping maintain metabolic homeostasis by ensuring energy needs are met, elimina...
Hanna Blaney,Adelina Horhat,Abdulmalik Saleem et al.
Hanna Blaney et al.
Alcohol-associated liver disease (ALD) is a leading cause of liver disease worldwide, caused by hazardous alcohol use. Many patients with ALD also have alcohol use disorder (AUD), a chronic mental health condition characterized by a cluster...
Combined hepatocellular-cholangiocarcinoma: a clinical and molecular review [0.03%]
肝细胞癌与胆管癌的临床和分子特征综述
Shaodian Xu,Julien Calderaro
Shaodian Xu
Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver malignancy characterized by the coexistence of both hepatocellular and biliary morphological differentiation. It is thought to represent less than 5% of all prima...