GLP-1RAs regulate lipid metabolism and induce autophagy through AMPK/SIRT1 pathway to improve NAFLD [0.03%]
GLP-1受体激动剂通过AMPK/SIRT1途径调节脂质代谢和诱导自噬以改善非酒精性脂肪肝病
Qiang Zhang,Jingyuan Wang,Xiaojin Hu et al.
Qiang Zhang et al.
Background: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of cirrhosis and a major risk factor for hepatocellular carcinoma and liver-related death. Diabetes medications have been studied as potential treat...
Effects of Statin Use on Blood Pressure and Other Hypertension-related outcome Indicators in Hypertensive Patients: A Systematic Review and Meta-analysis [0.03%]
他汀类药物对高血压患者血压及相关结果指标的影响：系统评价和.meta.分析
Zhaohan Chu,Wei Yue,Qingqing Mu et al.
Zhaohan Chu et al.
Aims: This meta-analysis delved into the impact of statin therapy, both as a monotherapy and in conjunction with antihypertensive medications, on blood pressure levels and outcomes pertinent to hypertension. ...
Decreased plasma lipoxin A4, resolvin D1, protectin D1 are correlated with the complexity and prognosis of coronary heart disease: a retrospective cohort study [0.03%]
冠心病的复杂性和预后的相关性研究中血浆脂氧素A4、分解物D1、保护素D1的含量降低：一项回顾性队列研究
Yun-Fei Wang,Xue-Tao Zhu,Ze-Ping Hu
Yun-Fei Wang
This study aimed to assess the predictive capacity of specialized pro-resolving mediators (SPMs) regarding the complexity and prognosis of coronary heart disease (CHD). Total of 602 CHD patients were included in this study and categorized i...
E2F7 upregulates MCM4 and fatty acid metabolism to advance lung adenocarcinoma metastasis [0.03%]
E2F7通过上调MCM4和脂肪酸代谢来促进肺腺癌的转移
WuAsen Tang,Deming Zhang,Di Liu et al.
WuAsen Tang et al.
[BACKGROUND]: MCM4, a key protein in MCM, is frequently overexpressed in cancers, but its specific role in lung adenocarcinoma (LUAD) metastasis is unclear. [METHODS]: Bioinformatics revealed the mRNA expression pattern of MCM4 in LUAD, whi...
SUPPRESSION OF ADIPOSE TGF-β1 BY PROBIOTICS ALLEVIATES METABOLIC DISTURBANCE IN EXPERIMENTALLY INDUCED PCOS [0.03%]
益生菌抑制脂肪组织TGF-β1改善实验性PCOS的代谢紊乱
Kehinde S Olaniyi,Doris O Okara,Stephanie E Areloegbe
Kehinde S Olaniyi
Background: Polycystic ovarian syndrome (PCOS) is critically characterized with metabolic and endocrine dysfunctions, precipitating metabolic syndrome and infertility in reproductive aged women. Adipose tissue dysfunction...
Ceramide and DNA damage in Liver Fibrosis: Exploring the Implications of Eicosapentaenoic Acid Encapsulation in Cellulose Nanocrystals [0.03%]
肝纤维化中的神经酰胺和DNA损伤：探讨封装在纤维素纳米晶体中的二十碳五烯酸的含义
Jihan Hussein,Mona A El-Bana,Rehab A Mohamed et al.
Jihan Hussein et al.
Ceramide plays a crucial role in promoting liver fibrosis by inducing apoptosis and inflammation in hepatocytes. Oxidative stress accelerates fibrosis by elevating levels of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), an indicator for the...
Involvement of COX inhibitor and arachidonic acid in manipulating obesity and obesity-induced bone resorption markers in obese mice [0.03%]
COX抑制剂和花生四烯酸在操纵肥胖小鼠的肥胖及由肥胖引发的骨吸收标记物中的作用
Rahima Begum,Sourav Roy,Md Abdur Rahman Ripon et al.
Rahima Begum et al.
Obesity and bone-loss have remained a focus of research. Obesity stimulates adipose tissue expansion and adipocyte hypertrophy, resulting in chronic low-grade inflammation in the adipocytes. This enlarged adipocyte secretes a variety of pro...
Effect of Menaquinone-7 (MK-7) Supplementation on Anthropometric Measurements, Glycemic Indices, and Lipid Profiles: A Systematic Review and Meta-Analysis of Randomized Controlled Trials [0.03%]
Menaquinone-7（MK-7）补充对人体测量、血糖指标和血脂的影响：随机对照试验的系统评价和荟萃分析
Omid Nikpayam,Ali Jafari,Amirhossein Faghfouri et al.
Omid Nikpayam et al.
Background: Menaquinone-7 (MK-7) is a type of vitamin K that has a longer half-life and stays in the body for a more extended period compared to other types of vitamin K. Recently, the effects of this vitamin on body weig...
The interplay of LDLR, PCSK9, and lncRNA- LASER genes expression in coronary artery disease: implications for therapeutic interventions [0.03%]
低密度脂蛋白受体、PCSK9和长链非编码RNA-LASER基因在冠状动脉疾病中的相互作用：对治疗干预的意义
Tayebe Ghiasvand,Jamshid Karimi,Iraj Khodadadi et al.
Tayebe Ghiasvand et al.
Background and purpose: Coronary artery disease (CAD) is defined as stenosis of coronary arteries due to atherosclerosis. The etiology of atherosclerosis can be attributed to a disruption in lipid metabolism, specifically...
Aspirin-triggered RvD1 (AT-RvD1) modulates epithelial-mesenchymal transition on bronchial epithelial cells stimulated with cigarette smoke extract [0.03%]
阿司匹林触发的RvD1(AT-RvD1)调节香烟烟雾提取物刺激的支气管上皮细胞的上皮间充质转化
Aline Beatriz Mahler Pereira,Bethânia Alves Gontijo,Sarah Cristina Sato Vaz Tanaka et al.
Aline Beatriz Mahler Pereira et al.
The epithelial-mesenchymal transition (EMT) plays significant role in airway remodeling during chronic obstructive pulmonary disease (COPD) and lung cancer. Aspirin-triggered resolvin D1 (AT-RvD1) presents anti-inflammatory and pro-resoluti...