Digoxin-Induced Gut Dysbiosis: Mechanistic Links to Prostaglandin Dysregulation and Lipid Metabolic Imbalance [0.03%]
洋地黄诱导的肠道菌群失调：与前列腺素调节异常和脂质代谢紊乱的机制联系
Nila Ganamurali,Sarvesh Sabarathinam
Nila Ganamurali
Digoxin, a cardiac glycoside with established roles in heart failure and arrhythmia, increasingly exemplifies drug-microbiome-host interactions. Its bioavailability and efficacy are profoundly influenced by Eggerthella lenta-mediated reduct...
SREBF1 maintains the contractile phenotype of vascular smooth muscle cells via PPARγ signalling [0.03%]
SREBF1通过PPARγ信号维持血管平滑肌细胞的收缩表型
Xiaoying Chen,Huiling Jin,Guanyi Zheng
Xiaoying Chen
Background: Atherosclerosis is a complex chronic inflammatory disease. Although SREBF1 has been implicated in the regulation of atherosclerotic progression, its precise mechanisms remain incompletely understood. ...
Ehsan Pashay Ahi,Andrew H House
Ehsan Pashay Ahi
Lipidomics, the comprehensive study of cellular lipids and their roles in biological systems, has become a transformative tool across diverse fields of biology and medicine. Beyond its applications in studying metabolic disorders and cancer...
Revealing the Biochemical Regulations of L-PGDS in Hepatic Insulin-Resistance using HepG2 cells [0.03%]
采用HepG2细胞揭示肝胰岛素抵抗下L-PGDS的生化调控机制
Rhema Khairnar,Md Asrarul Islam,Kuljeet Singh et al.
Rhema Khairnar et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease, and its prevalence poses a serious health threat globally. MASLD is a multifactorial hepatic disorder, but insulin resistance is a ke...
Lipocalin Prostaglandin D₂ Synthase (L-PGDS) Deficiency Disrupts Heme Catabolism and Iron Homeostasis in Mice [0.03%]
脂钙蛋白前列腺素D2合成酶(L-PGDS)缺陷通过破坏小鼠血红素分解代谢和铁稳态导致铁过载
Matthew Stevenson,Bryan Chen,Ankita Srivastava et al.
Matthew Stevenson et al.
Efficient recycling of red blood cells (RBCs) requires not only heme cleavage but also stabilization of reactive intermediates generated during iron liberation. Lipocalin Prostaglandin D₂ Synthase (L-PGDS, β-trace protein), best known for...
The association of Cytochrome 4F2 rs2108622 genetic variant and non-genetic factors with essential hypertension among Jordanian patients attending the University of Jordan Hospital [0.03%]
约旦河西岸地区University of Jordan医院就诊的高血压患者细胞色素P450 4F2基因多态性与非遗传因素的相关性研究
Enas Yousef Alkasasbeh,Yazun Bashir Jarrar,Wiam Khalil et al.
Enas Yousef Alkasasbeh et al.
Background: Essential hypertension (EH) contributes to death and morbidity. CYP4 genes influence EH via 20-hydroxyeicosatetraenoic acid production. Identifying genetic risk factors may reveal biomarkers for EH among Jorda...
Pro-inflammatory differentiation by GM-CSF reduces prostanoid release and phagocytic activity in murine bone marrow-derived macrophages [0.03%]
GM-CSF诱导的促炎分化通过减少小鼠骨髓来源的巨噬细胞中的前列环素释放和吞噬活性来抑制免疫反应
Jianyang Liu,Helena Idborg,Marina Korotkova et al.
Jianyang Liu et al.
Murine bone marrow-derived macrophages (BMDMs) are widely used to study macrophage functions in vitro. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) are routinely used to differen...
Impact of Overexpression of Wild-type CFTR and Elexacaftor-Tezacaftor-Ivacaftor on Oxylipin Production by the CFBE41o- Bronchial Epithelial Cell Line [0.03%]
野生型CFTR和Elexacaftor-Tezacaftor-Ivacaftor过表达对CFBE41o-支气管上皮细胞系氧脂质生成的影响
Dustin G Brown,Jonathan Manke,Michael Armstrong et al.
Dustin G Brown et al.
A hallmark of cystic fibrosis (CF) is dysregulated lipid metabolism marked by an imbalance of pro-inflammatory to pro-resolving metabolites. Despite the breadth of evidence associating mutation of the cystic fibrosis conductance regulator (...
The role of eicosapentaenoic acid-loaded nanoparticles on alleviating drug resistance in xenograft breast cancer model [0.03%]
一种二十碳五烯酸载药纳米颗粒逆转移植瘤小鼠乳腺癌耐药性的研究
Fatma F Elsayed,Dina M Abo-Elmatty,Zakaria El-Khayat et al.
Fatma F Elsayed et al.
Background: Multidrug resistance (MDR) is a major dilemma in the effective chemotherapy treatment of breast cancer. Potential strategies to combat MDR include inhibiting efflux pumps such as ATP-binding cassette (ABC) tra...
Prostaglandin E2 is a crucial intermediator of 17β-estradiol-induced growth factor expression in bovine endometrial cells and explants [0.03%]
前列腺素E2是雌二醇诱导牛子宫内膜细胞和组织切片生长因子表达的关键介质
Wenhui Bao,Shuangyi Zhang,Jiamin Zhao et al.
Wenhui Bao et al.
Estradiol is a critical hormone that regulates morphological and functional changes in the bovine endometrium throughout the estrous cycle. Prostaglandin E2 (PGE2), a well-established inflammatory mediator, also plays an essential role in e...