Exploring the Diverse Signaling Mechanisms of 17β-Estradiol Deficiency and Replacement: Impacts on Cognitive Dysfunction in a Post-Menopausal Experimental Model [0.03%]
探讨雌二醇缺乏及替代治疗多样化的信号机制：在绝经后认知功能障碍动物模型中的影响
Mona A El-Bana,Jihan Hussein,Sherien M El-Daly et al.
Mona A El-Bana et al.
This study aimed to investigate the pathways affected by estradiol deficiency during menopause and how these pathways are modified with 17β-estradiol replacement to mitigate menopause-related changes, particularly in cognitive function and...
Metabolic profiling of bioactive components from Schizophyllum commune Fries in hypercholesterolemic Wistar-Kyoto rats using LC-QTOF-MS analysis [0.03%]
LC-QTOF-MS分析法结合大鼠模型的裂褶菌活性成分代谢组学研究
Rushitha Sadasevevam,Norhaniza Aminudin,Noorlidah Abdullah
Rushitha Sadasevevam
Atherosclerosis is an inflammatory condition that contributes to myocardial infarction, cardiac arrest and stroke. Current knowledge of mushroom metabolomics in the context of atherosclerosis remains inadequate. Hence, further investigation...
Phagocytosis is differentially regulated by LPS in M1- and M2-like macrophages via PGE2 formation and EP4 signaling [0.03%]
脂多糖通过PGE2的形成和EP4信号传导不同调节M1和M2型巨噬细胞的吞噬作用
Rebecca Kirchhoff,Michel André Chromik,Nils Helge Schebb
Rebecca Kirchhoff
Phagocytosis is a key process in human innate immune response. Human macrophages are important phagocytes engulfing and neutralizing pathogens and cell debris. In addition, they modulate the inflammatory process by releasing cytokines and l...
Magnoflorine Alleviates Nonalcoholic Fatty Liver Disease by Modulating Lipid Metabolism, Mitophagy and Inflammation [0.03%]
Magnoflorine通过调节脂质代谢、线粒体自噬和炎症来缓解非酒精性脂肪肝病
Liming Wang,Yan Yang,Haibing Sun et al.
Liming Wang et al.
Background: Nonalcoholic fatty liver disease (NAFLD) is a prevalent liver condition associated with metabolic syndrome, often aggravated by inflammation and mitochondrial dysfunction. This study aims to explore the therap...
Advances and Challenges in Lipid Droplet Isolation for Animal Tissues and Cells [0.03%]
动物组织和细胞内脂滴分离的研究进展与挑战
Yangli Pei,Siyu Wu,Zheng Feng
Yangli Pei
Lipid droplets (LDs) are essential intracellular organelles involved in lipid storage and metabolism, playing critical roles in various cellular processes and diseases. Researchers must efficiently isolate and analyze LDs to understand lipi...
Protection of lutein against the toxic effect of cisplatin on liver in male rat [0.03%]
叶黄素对顺铂所致雄性大鼠肝毒性的影响研究
Ibrahim Aktas,Fatih Mehmet Gur,Sedat Bilgiç
Ibrahim Aktas
Objective: A major challenge in cancer treatment is the detrimental effects of anticancer drugs on healthy organs and tissues. This study aims to investigate the protective effects of Lutein (LU) against Cisplatin (CT)-in...
The effect of highly bioavailable forms of curcumin on lipoprotein(a) plasma levels: a systematic review and meta-analysis of randomized clinical studies [0.03%]
高生物利用度的姜黄素对脂蛋白(a)血浆水平的影响：随机对照试验的系统评价和meta分析
Federica Fogacci,Ashot Avagimyan,Arturo Cesaro et al.
Federica Fogacci et al.
Curcumin is a bioactive compound derived from the rhizome of Curcuma longa (turmeric) that has garnered increasing attention for its potential health benefits. However, its use in clinical practice is limited due to its generally poor bioav...
Oxysterols, age-related-diseases and nutritherapy: focus on 7-ketocholesterol and 7β-hydroxycholesterol [0.03%]
氧化固醇、与年龄有关的疾病和营养治疗：7-酮基胆固醇和7β-羟基金属固醇为重点的例子
Anne Vejux,Imen Ghzaiel,John J Mackrill et al.
Anne Vejux et al.
Age-related diseases are often associated with a disruption of RedOx balance that can lead to lipid peroxidation with the formation of oxysterols, especially those oxidized on carbon-7: 7-ketocholesterol (also known as 7-oxo-cholesterol) an...
An Updated Systematic Review and Meta-Analysis of Pomegranate Consumption on Lipid Profile [0.03%]
石榴摄入对血脂影响的系统评价和 meta 分析更新报告
Kaiqin Liang,Wengong Cheng,Aiqiong Huang
Kaiqin Liang
Pomegranate, rich in bioactive compounds such as polyphenols and flavonoids, has been studied for its potential lipid-modulating effects, yet evidence remains inconsistent. This systematic review and meta-analysis aimed to evaluate the impa...
Effects of walnut consumption on biomarkers of oxidative stress: A systematic review and meta-analysis of randomized controlled trials [0.03%]
碧根果摄取对氧化压力生物指标的影响：随机对照试验的系统回顾及元分析
Vali Musazadeh,Mahsa Mahmoudinezhad,Nilofar Hamidi et al.
Vali Musazadeh et al.
Oxidative stress is caused by an imbalance between accumulation and production of oxygen reactive species (ROS) in tissues and cells and play a key role in many diseases. This systematic review and meta-analysis of randomized controlled tri...