The effect of curcumin on paraoxonase 1 protein levels, gene expression, and enzyme activity: A systematic review of animal interventional studies [0.03%]
姜黄素对血清PARAOXONASE-1蛋白水平、基因表达及酶活性影响的动物实验系统评价研究
Fatemeh Hamedi-Kalajahi,Mohammad Alizadeh,Sorayya Kheirouri et al.
Fatemeh Hamedi-Kalajahi et al.
Background and aims: Paraoxonase (PON) proteins have various hydrolytic activities. The PON family is able to detoxify oxidized low-density lipoprotein. Additionally, differentiation of monocytes into macrophages, as the ...
Glucocorticoid resistance remodels liver lipids and prompts lipogenesis, eicosanoid, and inflammatory pathways [0.03%]
糖皮质激素抵抗重塑肝脏脂质并促进脂生成、二十烷酸和炎性途径
Genesee J Martinez,Zachary A Kipp,Wang-Hsin Lee et al.
Genesee J Martinez et al.
We have previously demonstrated that the glucocorticoid receptor β (GRβ) isoform induces hepatic steatosis in mice fed a normal chow diet. The GRβ isoform inhibits the glucocorticoid-binding isoform GRα, reducing responsiveness and indu...
EPA, DHA, and resolvin effects on cancer risk: The underexplored mechanisms [0.03%]
EPA、DHA和resolvin对癌症风险的影响：未被充分探索的机制
Yoshiyuki Kiyasu,Xiangsheng Zuo,Yi Liu et al.
Yoshiyuki Kiyasu et al.
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplements have exhibited inconsistent effects on cancer risk, and their potential efficacy as cancer preventive agents has been increasingly questioned, especially in recent large...
PGC-1α inhibits NLRP3 signaling through transcriptional activation of POP1 to alleviate inflammation and strengthen osteogenic differentiation of lipopolysaccharide-induced human periodontal stem cells [0.03%]
PGC-1α通过转录激活POP1抑制NLRP3信号，以缓解炎症并增强脂多糖诱导的人牙周干细胞成骨分化能力
Fuying Liang,Shanshan Huang
Fuying Liang
Periodontitis is a chronic infectious disease that affects the oral health of adults. Periodontal stem cells (PDLSCs) have good self-renewal and multipotential differentiation abilities to maintain the integrity of periodontal support struc...
Zerumbone exhibits anti-inflammatory effects by suppressing eicosanoid signaling: Evidence from LPS-induced peripheral blood leukocytes [0.03%]
zerumbone通过抑制脂氧素信号显示其抗炎作用：来自LPS诱导的外周血白细胞的证据
Vinayak Uppin,Mehrdad Zarei,Pooja Acharya et al.
Vinayak Uppin et al.
Zerumbone, a sesquiterpene isolated from Zingiber zerumbet, has many bioactivities, exhibiting anti-inflammatory properties. However, the effect of zerumbone on the eicosanoid signaling pathway has yet to be examined. Here, we deciphered th...
Changes in cardiovascular arachidonic acid metabolism in experimental models of menopause and implications on postmenopausal cardiac hypertrophy [0.03%]
绝经模型中心血管花生四烯酸代谢改变及对绝经后心脏肥大的影响
Samar H Gerges,Ayman O S El-Kadi
Samar H Gerges
Menopause is a normal stage in the human female aging process characterized by the cessation of menstruation and the ovarian production of estrogen and progesterone hormones. Menopause is associated with an increased risk of several differe...
Soluble epoxide hydrolase inhibition reverses cognitive dysfunction in a mouse model of metabolic syndrome by modulating inflammation [0.03%]
通过调节炎症反应缓解代谢综合征小鼠认知功能障碍的可溶性环氧化物水解酶抑制剂研究
Thierno M Bah,Catherine M Davis,Elyse M Allen et al.
Thierno M Bah et al.
Midlife metabolic syndrome (MetS) is associated with cognitive impairment in late life. The mechanism of delayed MetS-related cognitive dysfunction (MetSCD) is not clear, but it has been linked to systemic inflammation and chronic cerebral ...
Platelets and extracellular vesicles in disease promotion via cellular cross-talk and eicosanoid biosynthesis [0.03%]
细胞通讯和二十烷酸生物合成在血小板和细胞外囊泡介导的疾病发生发展中的作用
Annalisa Contursi,Stefania Tacconelli,Sara Di Berardino et al.
Annalisa Contursi et al.
New insights have been gained on the role of platelets beyond thrombosis. Platelets can accumulate in damaged and inflamed tissues, acting as a sentinel to detect and repair tissue damage. However, by releasing several soluble factors, incl...
Real time changes in the expression of eicosanoid synthesizing enzymes during inflammation [0.03%]
炎症过程中依可索底合成酶表达的实时变化
Hannah C Huff,Justin S Kim,Abhishek Ojha et al.
Hannah C Huff et al.
Immune responses during inflammation involve complex, well-coordinated lipid signaling pathways. Eicosanoids are a class of lipid signaling molecules derived from polyunsaturated fatty acids such as arachidonic acid and constitute a major n...
Impact of flaxseed supplementation on lipid profile and liver enzymes in patients with non-alcoholic fatty liver disease: Systematic review and meta-analysis of randomized controlled trials [0.03%]
亚麻籽补充对非酒精性脂肪肝病患者血脂和肝酶影响的系统评价和meta分析
Dyari H Ahmed,Hawal Lateef Fateh
Dyari H Ahmed
Since the effects of flaxseed supplementation on lipid profile and liver enzymes are still controversial, a meta-analysis of randomized controlled trials was conducted in the present study to assess the effect of flaxseed supplementation on...