From decline to resurgence: current perspectives on Mycoplasma pneumoniae [0.03%]
从衰落走向复兴——肺炎支原体研究现状及展望
Ying Liu,Qing Ye
Ying Liu
SUMMARYMycoplasma pneumoniae pneumonia (MPP) is an acute respiratory infection caused by Mycoplasma pneumoniae (MP) and constitutes the primary cause of community-acquired pneumonia (CAP) among children aged 5 years and older in China. The ...
Advancement of LAMP technologies for rapid and accurate diagnosis of infectious diseases [0.03%]
LAMP技术在感染性疾病快速精准诊断中的应用进展
Ryan Chaffee,Nabil Royez,Jack Burke-Gaffney et al.
Ryan Chaffee et al.
SUMMARYLoop-mediated isothermal amplification (LAMP) is a type of isothermal nucleic acid amplification test (NAAT). Compared to more traditional NAATs, like polymerase chain reaction (PCR), LAMP is run at one consistent temperature, utiliz...
DNA sequencing for microbial surveillance in cystic fibrosis airways: advances, challenges, and clinical translation [0.03%]
囊性纤维化呼吸道微生物监测的DNA测序技术：进展、挑战及临床转化
Jessica A P Carlson-Jones,Thomas R Goddard,Bhavya Papudeshi et al.
Jessica A P Carlson-Jones et al.
SUMMARYDNA sequencing has revolutionized microbial surveillance in cystic fibrosis (CF), transforming pathogen identification from culture-dependent to total microbial community identification using molecular-based approaches. Techniques su...
Intra-amniotic infection: diagnosis, nomenclature, clinical significance, management, and microbiologic tools used for the diagnosis [0.03%]
宫内感染的诊断、命名、临床意义、处理及微生物学检测方法
Pisut Pongchaikul,Puntabut Warintaksa,Piroon Jenjaroenpun et al.
Pisut Pongchaikul et al.
SUMMARYIntra-amniotic infection is the main cause of spontaneous preterm birth and adverse maternal-fetal outcomes; therefore, rapid, robust, and accurate diagnosis remains a clinical priority. Conventional microbiological techniques, espec...
Leptospira-host interactions: advancing next-generation vaccines and diagnostics [0.03%]
钩端螺旋体与宿主的相互作用：推进新一代疫苗和诊断方法的发展
Bothammal Palanisamy,Syed M Faisal
Bothammal Palanisamy
SUMMARYLeptospirosis, a widespread zoonotic disease caused by pathogenic Leptospira species, remains a major public health challenge, particularly in tropical and subtropical regions. Despite advances in understanding Leptospira biology and...
Elhadji Birane Mboup,Julia Dubois,Marie-Ève Hamelin et al.
Elhadji Birane Mboup et al.
SUMMARYThe year 2026 marks the 25th anniversary of the discovery of human metapneumovirus (HMPV), which belongs to the metapneumovirus genus within the Pneumoviridae family. The respiratory syncytial virus (RSV), discovered in 1956, is a cl...
Diagnostic challenges in re-emerging rickettsioses: why current tools fall short [0.03%]
再发立克次体感染的诊断挑战：现有工具为何不足？
Yaawar Bashir Mir,Tasaduq Manzoor,Danish Mushtaq et al.
Yaawar Bashir Mir et al.
SUMMARYRickettsial diseases, encompassing scrub typhus, spotted fever group rickettsioses, and typhus group rickettsioses, represent a significant and escalating public health threat worldwide, particularly in the Asia-Pacific and sub-Sahar...
Current progress in developing mRNA-lipid nanoparticle vaccines against human bacterial pathogens [0.03%]
针对人类细菌病原体的mRNA-脂质纳米颗粒疫苗研发进展
Brody Pullinger,Nichaela Harbison-Price,Ismail Sebina et al.
Brody Pullinger et al.
SUMMARYThe messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccine platform is the newest tool in the vaccination arsenal for combating infectious diseases, rare genetic diseases, and cancer. Since 2020, major advances in preclinical and clin...
Matthew Dietz,Subbaya Subramanian,Christopher Staley
Matthew Dietz
SUMMARYColorectal cancer (CRC) is a significant global health concern that is growing in prevalence, especially in younger populations. The gut microbiome is an increasingly recognized factor in the development and progression of numerous d...
Influence of fungi on epithelial homeostasis and role in inflammatory diseases [0.03%]
真菌对上皮稳态的影响及其在炎症性疾病中的作用
Liam F Peterson,Jingyi Wang,Neil A R Gow et al.
Liam F Peterson et al.
SUMMARYThe skin harbors a diverse fungal community that contributes to both epidermal homeostasis and inflammatory disease. Historically, studies of cutaneous fungi focused primarily on opportunistic infections in immunocompromised hosts. A...