Leptospira-host interactions: advancing next-generation vaccines and diagnostics [0.03%]
钩端螺旋体与宿主的相互作用：推进新一代疫苗和诊断方法的发展
Bothammal Palanisamy,Syed M Faisal
Bothammal Palanisamy
SUMMARYLeptospirosis, a widespread zoonotic disease caused by pathogenic Leptospira species, remains a major public health challenge, particularly in tropical and subtropical regions. Despite advances in understanding Leptospira biology and...
Elhadji Birane Mboup,Julia Dubois,Marie-Ève Hamelin et al.
Elhadji Birane Mboup et al.
SUMMARYThe year 2026 marks the 25th anniversary of the discovery of human metapneumovirus (HMPV), which belongs to the metapneumovirus genus within the Pneumoviridae family. The respiratory syncytial virus (RSV), discovered in 1956, is a cl...
Diagnostic challenges in re-emerging rickettsioses: why current tools fall short [0.03%]
再发立克次体感染的诊断挑战：现有工具为何不足？
Yaawar Bashir Mir,Tasaduq Manzoor,Danish Mushtaq et al.
Yaawar Bashir Mir et al.
SUMMARYRickettsial diseases, encompassing scrub typhus, spotted fever group rickettsioses, and typhus group rickettsioses, represent a significant and escalating public health threat worldwide, particularly in the Asia-Pacific and sub-Sahar...
Current progress in developing mRNA-lipid nanoparticle vaccines against human bacterial pathogens [0.03%]
针对人类细菌病原体的mRNA-脂质纳米颗粒疫苗研发进展
Brody Pullinger,Nichaela Harbison-Price,Ismail Sebina et al.
Brody Pullinger et al.
SUMMARYThe messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccine platform is the newest tool in the vaccination arsenal for combating infectious diseases, rare genetic diseases, and cancer. Since 2020, major advances in preclinical and clin...
Matthew Dietz,Subbaya Subramanian,Christopher Staley
Matthew Dietz
SUMMARYColorectal cancer (CRC) is a significant global health concern that is growing in prevalence, especially in younger populations. The gut microbiome is an increasingly recognized factor in the development and progression of numerous d...
Influence of fungi on epithelial homeostasis and role in inflammatory diseases [0.03%]
真菌对上皮稳态的影响及其在炎症性疾病中的作用
Liam F Peterson,Jingyi Wang,Neil A R Gow et al.
Liam F Peterson et al.
SUMMARYThe skin harbors a diverse fungal community that contributes to both epidermal homeostasis and inflammatory disease. Historically, studies of cutaneous fungi focused primarily on opportunistic infections in immunocompromised hosts. A...
Coxsackievirus A6 on the rise: epidemiology, pathogenicity, evolutionary dynamics, and antiviral strategy [0.03%]
柯萨奇病毒A6流行趋势：流行病学、致病性、进化动力学及抗病毒策略
Xianfeng Zhou,Fenglan He,Ziqi Lin et al.
Xianfeng Zhou et al.
SUMMARYIn recent years, coxsackievirus A6 (CVA6) has become a predominant cause of hand, foot, and mouth disease (HFMD) worldwide, surpassing enterovirus A71 (EV-A71) and CVA16. The rise of CVA6 is of particular public health concern due to...
Intravesical therapies for catheter-associated urinary tract infections: current approaches and future directions [0.03%]
导管相关性尿路感染的膀胱内治疗：目前的方法及未来的发展方向
Chloe Linham,Mark Webber,Sheng Qi
Chloe Linham
SUMMARYUrinary tract infections (UTIs) are among the most common bacterial infections worldwide, with catheter-associated UTIs (CAUTIs) representing a major subset in healthcare settings. CAUTIs significantly increase patient morbidity, mor...
Plasmodium vivax malaria in India: microbiological barriers to diagnosis, treatment, and elimination [0.03%]
印度恶性疟疾的诊断、治疗和根除面临的微生物学障碍
Chandan Kumar,Praveen K Bharti,Himanshu Gupta
Chandan Kumar
SUMMARYPlasmodium vivax remains a major barrier to global malaria elimination due to dormant liver-stage hypnozoites that drive relapse and sustain transmission even in low-endemic settings. India accounts for nearly half of the global P. v...
The gut microbiome in preterm infants: development, dysbiosis, and disease implications [0.03%]
早产婴儿肠道微生物组的发育、失调及对疾病的启示
Enfu Tao,Lizhen Wang,Tianming Yuan
Enfu Tao
SUMMARYPreterm infants face a unique trajectory of gut microbiome assembly, shaped by the convergence of physiological immaturity, necessary clinical interventions, and the neonatal intensive care unit environment. This dysbiotic ecosystem-...