Erratum for Chou et al., "Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance" [0.03%]
周等人文章的勘误：“体外筛选出的新型人巨细胞病毒UL54 DNA聚合酶基因突变可使贝西朵伏索菲产生抗药性”
Sunwen Chou,Ronald J Ercolani,E Randall Lanier
Sunwen Chou
Published Erratum
Antimicrobial agents and chemotherapy. 2026 Aug 7:e0102426. DOI:10.1128/aac.01024-26 2026
The effect of metformin on the pharmacokinetics of rifampicin, isoniazid, and pyrazinamide in adults with tuberculosis [0.03%]
二甲双胍对结核病成人患者利福平、异烟肼和吡嗪酰胺药代动力学的影响
Jacques Rossouw,Robert Wallis,Hardy Kornfeld et al.
Jacques Rossouw et al.
Metformin is under investigation as adjunctive host-directed therapy for tuberculosis (TB), which might interact with first-line TB treatment. We used population pharmacokinetic modeling to assess whether metformin alters first-line TB-drug...
NT-A9, a new triazole, exhibits potent antifungal activity against Candida and Cryptococcus species through potent ergosterol biosynthesis inhibition [0.03%]
NT-A9，一种新型三唑类化合物可通过强力抑制固醇生物合成展示出对假丝酵母和念珠菌强有力的抗真菌活性
Shuo Zhu,Tingjunhong Ni,Lu Gao et al.
Shuo Zhu et al.
Invasive fungal infections (IFIs) remain a major global health threat due to limited therapeutic options and rising azole resistance. NT-a9 is a novel triazole antifungal with potent activity against Candida and Cryptococcus species via str...
Establishment of epidemiological cutoff values for yeast-phase Talaromyces marneffei against six antifungal agents: a multicenter study in China [0.03%]
中国六种抗真菌药物对玛菲奴卡式囊霉（酵母型）的流行病学切值建立：多中心研究
Kai-Su Pan,Ying-Gai Song,Sha Lu et al.
Kai-Su Pan et al.
This study aimed to establish epidemiological cutoff values (ECVs) for amphotericin B, fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole against Talaromyces marneffei (T. marneffei) using the CLSI broth microdilution ...
Identification of a hypervirulent extensively drug-resistant ST383 Klebsiella pneumoniae sub-lineage carrying ICEKp5 in Lebanon [0.03%]
在黎巴嫩鉴定出一种携带ICEKp5的高毒力、多重耐药型ST383肺炎克雷伯菌亚系
Martine Abboud,Tia Clara Chaaya,Yara Daccache et al.
Martine Abboud et al.
Klebsiella pneumoniae ST383 has emerged as a high-risk clone, characterized by carbapenem resistance and increasing detection of hypervirulence determinants. We describe a phylogenetically distinct ST383 sub-lineage in Lebanon, defined by t...
Plasma concentrations of nirmatrelvir and molnupiravir required for inhibition of SARS-CoV-2 replication differ between rhesus macaques and humans [0.03%]
用于抑制恒河猴和人类中SARS-CoV-2复制的奈玛特韦和莫诺匹拉韦浓度不同
Ugo Avila-Ponce de Leon,Shadisadat Esmaeili,Katherine Owens et al.
Ugo Avila-Ponce de Leon et al.
Early during the COVID-19 pandemic, non-human primate (NHP) infection models emerged as highly useful tools for preclinical screening of antiviral drugs. However, it is uncertain whether NHP models can be used to precisely inform optimal do...
Genome-wide transposon screening uncovers phage resistance mechanisms and bidirectional effects on antibiotic susceptibility in carbapenem-resistant Klebsiella pneumoniae [0.03%]
全基因组转座子筛选揭示了碳青霉烯耐药肺炎克雷伯菌中的噬菌体抗性机制及其对药物敏感性的双向影响
Zhichen Zhu,Tengfei Long,Bingjie Wang et al.
Zhichen Zhu et al.
Phage therapy and phage-antibiotic combinations are promising strategies against multidrug-resistant pathogens like carbapenem-resistant Klebsiella pneumoniae (CRKP). However, the mechanisms underlying phage resistance and the molecular bas...
Emergence of mutHV76G in carbapenem-resistant Klebsiella pneumoniae disrupts DNA mismatch repair and results in a hypermutator phenotype [0.03%]
碳青霉烯耐药肺炎克雷伯菌中mutHV76G的出现破坏DNA错配修复并导致超突变表型
Shaoji Cheng,Cornelius J Clancy,Giuseppe Fleres et al.
Shaoji Cheng et al.
Hypermutation-driven evolution is a major contributor to antibiotic resistance in some bacterial pathogens, but its role in Klebsiella pneumoniae remains poorly defined. We analyzed 11 KPC-producing ST258 K. pneumoniae isolates collected se...
Targeting SARS-CoV-2 programmed -1 ribosomal frameshifting: structural dynamics and RNA-directed antiviral strategies [0.03%]
靶向SARS-CoV-2程序化-1核糖体 frameshifting： 结构动态和RNA导向的 抗病毒策略
Neha Jeena,Inshad Ali Khan
Neha Jeena
Programmed -1 ribosomal frameshifting (-1 PRF) is a translational recoding mechanism used by many RNA viruses to regulate the expression of viral replication proteins. In coronaviruses, including SARS-CoV-2, -1 PRF is controlled by a conser...
In vitro activity of zoliflodacin against Neisseria gonorrhoeae collected in the United States from 2020 to 2022 [0.03%]
2020至2022年美国地区淋病奈瑟菌对zoliflodacin的体外敏感性监测结果分析
Sarah M McLeod,Samir H Moussa,Meredith Hackel et al.
Sarah M McLeod et al.
Zoliflodacin is a first-in-class spiropyrimidinetrione, oral, single-dose antibacterial recently approved by the US FDA for treatment of uncomplicated urogenital gonorrhea. Isolates of Neisseria gonorrhoeae (n = 322) collected in the United...