Peroxin Pex8 couples stress responses, antifungal tolerance, and virulence regulation in Candida albicans [0.03%]
Bangsheng Xi,Yongqin Wu
Bangsheng Xi
Candida albicans, a World Health Organization critical-priority fungal pathogen, represents the predominant cause of candidemia. Therapeutic failure is sometimes driven by antifungal tolerance, a phenotype distinct from resistance, whose un...
Identification and characteristics of a novel acquired aminoglycoside phosphotransferase, APH(3')-IVb, from Riemerella anatipestifer [0.03%]
Mingkang Zhou,Zhishuang Yang,Mingshu Wang et al.
Mingkang Zhou et al.
A novel acquired aminoglycoside resistance gene, aph(3')-IVb, was identified via whole-genome sequencing of a multidrug-resistant Riemerella anatipestifer isolate from a duck. The gene encodes a 262-amino-acid phosphotransferase, APH(3')-IV...
Comparative in vitro activity of aztreonam-avibactam and aztreonam plus ceftazidime-avibactam against Stenotrophomonas maltophilia complex [0.03%]
Ashlan J Kunz Coyne,Rachel Gray,Pavani Gonnabathula et al.
Ashlan J Kunz Coyne et al.
Members of the Stenotrophomonas maltophilia complex are intrinsically multidrug-resistant pathogens that disproportionately affect critically ill patients. Aztreonam-avibactam (ATM-AVI), FDA approved in 2025, combines aztreonam (ATM; stable...
Inna A Volynkina,Michael O Bortyazh,Chih-Wei Chen et al.
Inna A Volynkina et al.
The rapid increase in antimicrobial resistance underscores the urgent need for new antibacterial agents. One promising strategy involves designing novel compounds through targeted chemical modifications of existing antibiotics. Azithromycin...
Piperacillin-tazobactam resistance in Klebsiella pneumoniae is often associated with IS 26- mediated blaSHV-1 amplification in a widespread Klebsiella-adapted plasmid [0.03%]
Guilhem Royer,Maxime Danjean,Christophe Rodriguez et al.
Guilhem Royer et al.
Piperacillin-tazobactam (TZP) resistance in Klebsiella pneumoniae involves diverse mechanisms with unclear prevalence and phenotypic impact. To elucidate these mechanisms, we analyzed K. pneumoniae clinical isolates resistant to TZP but sus...
Polygenic, cell-envelope adaptations drive high-frequency daptomycin resistance in Staphylococcus capitis NRCS-A from neonatal sepsis and NEC [0.03%]
Lara Kränkel,Janna Hauser,Jessica Slavetinsky et al.
Lara Kränkel et al.
Staphylococcus capitis NRCS-A is a major cause of neonatal sepsis worldwide and exhibits resistance to multiple antibiotics. We assessed the prevalence and mechanisms of daptomycin resistance (DAP-R) in bloodstream isolates from a German ne...
Comparative outcomes of ceftazidime-avibactam versus meropenem-vaborbactam for KPC-producing Enterobacterales infections [0.03%]
Sara M Karaba,Dariusz A Hareza,Jose M Munita et al.
Sara M Karaba et al.
Thirty-day mortality was similar in a propensity-score-weighted cohort of 73 patients with KPC-producing Enterobacterales infections treated with ceftazidime-avibactam or meropenem-vaborbactam. Emergence of resistance was higher in the ceft...
Multifunctional ACE2-nanobody fusion design for pan-specific neutralization and cardiovascular protection in SARS coronavirus infection [0.03%]
Traian Sulea,Matthew Stuible,Maria Moreno et al.
Traian Sulea et al.
Severe acute respiratory syndrome coronaviruses use the ACE2 receptor for viral entry while downregulating its activity, potentially leading to hypertension and major organ injuries. Dual-action technologies based on soluble ACE2 aimed to n...
Yue Zhang,Yi Tang,Yanjie Zhou et al.
Yue Zhang et al.
To evaluate the safety and efficacy of echinocandins (rezafungin, RZF; anidulafungin, AFG) in Candida albicans (C. albicans) endophthalmitis, with a particular focus on the novel drug RZF. In vitro safety was assessed by CCK-8 and live/dead...
Single point mutations in global regulatory genes restore cephalosporin resistance in a low-MIC Enterococcus faecium natural isolate [0.03%]
Miquel Sánchez-Osuna,Paula Bierge,Inmaculada Gómez-Sánchez et al.
Miquel Sánchez-Osuna et al.
Enterococcus faecium exhibits intrinsic resistance to cephalosporins (CPHs), yet the genetic determinants of this phenotype remain incompletely understood. To date, E. faecium strains with low minimum inhibitory concentrations (MICs) of CPH...