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Population pharmacokinetics study on nebulized and intravenous administration of polymyxin B in patients with pneumonia caused by multidrug-resistant gram-negative bacteria [0.03%] 吸入和静脉给药多黏菌素B治疗多重耐药革兰阴性杆菌肺炎患者的群体药代动力学研究
Xueyong Li,Lili Zhou,Danjie Wang et al. Xueyong Li et al.
Polymyxin B (PMB) remains a last-line therapeutic agent for multidrug-resistant gram-negative bacteria (MDR-GNB) infections. However, reliable pharmacokinetic (PK) data to guide nebulized PMB dosing regimens in critically ill patients are l...
PKPD modeling of the inoculum effect of combined ceftazidime/avibactam and colistin against KPC-3 Klebsiella pneumoniae isolate [0.03%] 头孢他啶/阿维巴坦与多粘菌素联合对KPC-3耐药肺炎克雷伯菌的接种效应PK/PD模型研究
Romain Aubry,Julien M Buyck,Alexia Chauzy et al. Romain Aubry et al.
The inoculum effect (IE) characterizes a decrease in the antimicrobial effect of antibiotics with increasing inoculum. To face antimicrobial resistance, antibiotic combinations are progressively used. In this context, the effect of combinat...
Combating yellow fever virus with 7-deaza-7-fluoro-2'-C-methyladenosine [0.03%] 利用7-脱氧-7氟-2'-C-甲基腺苷对抗黄热病毒
Julia C LeCher,Vivian Vasconcelos Costa,Lauren N Rust et al. Julia C LeCher et al.
Yellow fever virus (YFV) is a deadly zoonotic flavivirus endemic in tropical/sub-tropical Africa and South America transmitted by mosquito vector (Aedes aegypti; Haemagogus leucocelaenus) to humans and non-human primates. There are no appro...
NDM-5-carried outer membrane vesicles impair the efficacy of antibiotics against bacterial infections [0.03%] NDM-5携带的外膜囊泡影响抗生素对细菌感染的作用效力
Lin Li,Yanfang Zhang,Liangyun Weng et al. Lin Li et al.
The intensifying use of antimicrobials in the rapidly growing livestock industry has heightened concerns over the proliferation of antibiotic resistance, particularly among Enterobacteriaceae producing β-lactamase. Elucidating the role of ...
Norelle L Sherry,Jean Y H Lee,Stefano G Giulieri et al. Norelle L Sherry et al.
Antimicrobial resistance (AMR) is a critical global public health threat, with bacterial pathogens of primary concern. Pathogen genomics has revolutionized the study of bacterial pathogens and provided deep insights into the mechanisms and ...
Q24.12024 Review Antimicrobial agents and chemotherapy. 2025 Apr 14:e0108224. DOI:10.1128/aac.01082-24 2025
Comparative efficacy of levofloxacin, azithromycin, and doxycycline prophylaxis and treatment in an experimental Ureaplasma murine lung infection model [0.03%] 左氧氟沙星、阿奇霉素和多西环素在小鼠脲原体肺感染模型中预防及治疗效果的比较研究
Derek Fleming,Maha Y Al-Jabri,Robin Patel Derek Fleming
Although lung transplant recipients who develop Ureaplasma-associated hyperammonemia syndrome are treated with Ureaplasma-targeted antibiotics, optimal therapy is incompletely defined, and typically not based on real-time antimicrobial susc...
Population pharmacokinetic analysis of tobramycin in serum and ELF using data from patients with pneumonia [0.03%] 基于肺部感染患者数据的地托溴铵在血清和ELF中的群体药代动力学分析
Scott A Van Wart,Michael Trang,M Courtney Safir et al. Scott A Van Wart et al.
Population pharmacokinetic analyses were undertaken to characterize epithelial lining fluid (ELF) penetration for tobramycin in pneumonia patients. A two-compartment model with zero-order intravenous input and first-order elimination linked...
Impact of hepatic impairment and renal failure on the pharmacokinetics of linezolid and its metabolites: contribution of hepatic metabolism and renal excretion [0.03%] 肝脏损害和肾衰对利奈唑胺及代谢产物药代动力学的影响：肝代谢和肾排泄的作用
Jinyao Liu,Yingying Pang,Wenyan Li et al. Jinyao Liu et al.
Linezolid, an oxazolidinone antibiotic, is used in patients with liver or kidney disease. However, the effects and mechanisms of hepatic impairment or renal failure on the pharmacokinetics of linezolid and its metabolites (PNU-142586 and PN...
Novel Plasmodium falciparum Kelch13 polymorphisms in Cameroon with structural and physicochemical impact [0.03%] 喀麦隆新型恶性疟原虫Kelch13多态性及其结构和理化特性的影响
Loick P Kojom Foko,Jahnvi Jakhan,Geetika Narang et al. Loick P Kojom Foko et al.
The recent emergence of Plasmodium falciparum (Pf) parasites resistant to artemisinin-based combination therapies (ACT) in Africa has outlined the need for continuous molecular surveillance of artemisinin partial resistance. Here, the genet...
Harnessing the effect of iron deprivation to attenuate the growth of opportunistic pathogen Acinetobacter baumannii [0.03%] 利用铁剥夺抑制条件致病菌鲍曼不动杆菌的生长效应
Sujata Saha,Debasrita RoyChowdhury,Ali Hossain Khan et al. Sujata Saha et al.
Acinetobacter baumannii is an opportunistic pathogen having high infectivity among immunocompromised patients. The bacteria are resistant to major first-line antibiotics and have become a serious concern in the aspect of nosocomial and comm...