Siobhan A Cusack,Sebastián Riquelme-Barrios,Luis Rivera-Montero et al.
Siobhan A Cusack et al.
SUMMARYRNA modifications in the tRNA, rRNA, and mRNA constitute a widespread layer of post-transcriptional gene regulation, commonly known as the epitranscriptome. In bacteria, tRNA and rRNA modifications are well documented and play essent...
Helicobacter pylori geographic variation: a window into global differences in gastric cancer incidence [0.03%]
幽门螺杆菌的地域差异：一扇展示胃癌发病率全球差异的窗口
Chiamaka D Okoye,Georgia C Caso,Timothy L Cover
Chiamaka D Okoye
SUMMARYHelicobacter pylori infection is the strongest known risk factor for gastric cancer, a leading cause of cancer-related deaths worldwide. There is marked global geographic variation in both the incidence of gastric cancer and genetic ...
Lifestyle plasticity and the shared hypocrealean toolkit across Fusarium, Metarhizium, and Trichoderma [0.03%]
裂褶菌、绿僵菌和青霉菌共用的钩丝核盘菌工具箱及其生活方式的可塑性
Raymond J St Leger,Huiyu Sheng,Alexander X Hafer
Raymond J St Leger
SUMMARYFungi in the genera Fusarium, Metarhizium, and Trichoderma (FMT) are traditionally defined by their roles as plant pathogens, insect pathogens, and mycoparasites, respectively. However, these classifications obscure both their shared...
LD-transpeptidation in bacterial cell walls: biochemical principles and functional diversity [0.03%]
细菌细胞壁中的LD-转肽作用：生化原理与功能多样性
Barbara Walenkiewicz,Laura Alvarez,Felipe Cava
Barbara Walenkiewicz
SUMMARYPeptidoglycan (PG) is a dynamic, load-bearing polymer whose crosslinking chemistry governs envelope mechanics, growth modes, and stress tolerance. For decades, PG crosslinking was viewed primarily through the lens of penicillin-bindi...
Zhemin Zhang,Emma Kundracik,Wei Li et al.
Zhemin Zhang et al.
SUMMARYThe mycobacterial cell envelope, one of the most complex membranes found in bacteria, plays a major role in bacterial pathogenesis, virulence, and antimicrobial resistance. Biogenesis and modeling of this cell envelope are heavily in...
Yu Hua
Yu Hua
SUMMARYMendel's Law of Segregation posits an equal probability for each allele to be inherited during sexual reproduction. This process, however, is subverted by killer meiotic drivers (KMDs)-selfish genetic elements that enhance their own ...
From dividing to dormant: embracing the full activity spectrum for environmental microorganisms [0.03%]
从划分到休眠：拥抱环境微生物完整活性谱系
Ludivine Guigard,Victor Bal,A Fina Bintarti et al.
Ludivine Guigard et al.
SUMMARYMicroorganisms can cope with stress by entering dormancy, a viable state of reduced metabolic activity that enables persistence, dispersal, and long-term survival. However, microbial life in environmental systems is best understood a...
Juan Ortiz-Mateu,Luis Martinez-Gil
Juan Ortiz-Mateu
SUMMARYClass I fusion proteins are trimeric viral membrane proteins that mediate fusion between the virion and cellular membranes. In their prefusion state, they comprise three domains: a globular "head" domain that binds the target cell re...
Carmen Hoffbeck,Michael W Taylor
Carmen Hoffbeck
SUMMARYReptiles are a diverse and speciose class of animals that are broadly threatened by habitat loss, climate change, and other factors. From a microbiological perspective, reptiles have historically been examined as a source of disease,...
Overcoming the energy-dependent barrier to aminoglycoside uptake: multimodal strategies to sensitize Staphylococcus aureus persisters [0.03%]
克服氨基糖苷类药物摄取的能耗依赖性屏障：用于使耐药金黄色葡萄球菌休眠体敏感多模态策略
Seongeun Baek,Young June Choe,Philip S Yune et al.
Seongeun Baek et al.
SUMMARYPersistent Staphylococcus aureus infections pose a major therapeutic challenge due to the formation of metabolically dormant persister cells that survive antibiotic exposure without acquiring genetic resistance. Despite their potent ...