Velvet regulators as master integrators of development, metabolism, and pathogenicity in filamentous fungi [0.03%]
织态调控因子通过整合丝状真菌的发育、代谢和致病性发挥主要作用
Wanping Chen,Ye-Eun Son,He-Jin Cho et al.
Wanping Chen et al.
SUMMARYThe velvet family of fungal regulatory proteins constitutes a unique and evolutionarily conserved set of transcriptional and epigenetic regulators that coordinate development, secondary metabolism, and pathogenicity in filamentous fu...
Rajeev Misra
Rajeev Misra
SUMMARYAntibiotic resistance is a major global health threat, with an estimated 1.14 million deaths in 2021 linked to antibiotic resistance. Mutations naturally arise as bacteria evolve to defend against and survive various environmental ch...
Discovery and biosynthesis of antifungal microbial secondary metabolites [0.03%]
抗真菌微生物次生代谢产物的发现和生物合成研究进展
Blondelle Matio Kemkuignou,Magnus Haahr,Matiss Maleckis et al.
Blondelle Matio Kemkuignou et al.
SUMMARYThe high mortality associated with invasive fungal infections, coupled with limited therapeutic options, underscores the urgent need for antifungal agents with novel mechanisms of action. Natural products represent a particularly val...
New tools for exploring parasite biology and elucidating host-pathogen interactions in cryptosporidiosis [0.03%]
用于探索隐孢子虫病寄生虫生物学和阐明宿主病原体相互作用的新工具
Abigail Kimball,Wanyi Huang,Iti Saraav et al.
Abigail Kimball et al.
SUMMARYCryptosporidiosis is a major public health concern, the extent of which has only truly been appreciated within the last decade. Cryptosporidium research has undergone a renaissance, with new insights into population structure, specie...
Shambhavi Garde,Debnita Mongal,Manjula Reddy
Shambhavi Garde
SUMMARYBacterial cell walls are made up of peptidoglycan (PG), a primary load-bearing layer that forms a protective exoskeleton around the cytoplasmic membrane. PG is a heteropolymer composed of glycan chains attached to short peptides that...
The many journeys of botulinum neurotoxins and the bacteria that produce them-evolutionary, geographic, and research-related movements that have contributed to our understanding of a diverse pathogen [0.03%]
肉毒杆菌神经毒素及其产生菌的多种旅程——进化、地理和研究相关运动使我们了解这一复杂病原体
Theresa J Smith
Theresa J Smith
SUMMARYBotulism is a neuroparalytic intoxication caused by a collection of large proteins, known as botulinum neurotoxins (BoNTs), that are related in amino acid sequence and structure. The extreme potency of BoNTs can be traced to their ab...
Ana Belén Ramos-Aloi,Luciana Soledad Arias,Alipio Pinto et al.
Ana Belén Ramos-Aloi et al.
SUMMARYThe primary objective of this review is to provide an update on the most recent findings concerning the adverse effects of Shiga toxin-producing Escherichia coli (STEC) on the central nervous system (CNS), from both clinical and expe...
Rebekkah E Pope,Rolf A Prade
Rebekkah E Pope
SUMMARYIn fungi, the endomembrane system is a pleiomorphic, dynamic network of organelles, driven by vesicle trafficking pathways, which maintain cellular homeostasis, hyphal polar growth, and the secretion of proteins and metabolites. In s...
Advancing Africa's bioeconomy and biosolutions through microbial natural product discovery: unlocking indigenous microbe potential for sustainability [0.03%]
通过微生物天然产物发现推动非洲生物经济和生物解决方案的发展：解锁土著微生物潜力以实现可持续发展
Adetomiwa Ayodele Adeniji,Du Toit Loots
Adetomiwa Ayodele Adeniji
SUMMARYAfrica's rich microbial diversity presents a significant opportunity to drive innovation in healthcare, agriculture, and industrial biotechnology through microbial natural product discovery. However, despite its potential, the contin...
Escherichia albertii: the still unfolding journey of a misdiagnosed pathogen that became a new species and a new member of the family of attaching and effacing enteric bacterial pathogens [0.03%]
爱氏志贺菌：一种被误诊的病原菌成为新物种及黏附性肠杆菌科病原菌家族的新成员之旅
Shinji Yamasaki,Atsushi Hinenoya,Dieter Bulach et al.
Shinji Yamasaki et al.
SUMMARYEscherichia albertii, initially identified as Hafnia alvei, by the commercial identification biochemical strip, API 20E, was isolated from an infant with diarrhea in Bangladesh in 1989. However, this bacterium was later renamed as a ...