Understanding the Impact of Mutations in the Cystathionine Beta-Synthase Gene: Towards Novel Therapeutics for Homocystinuria [0.03%]
cystathionine β-合成酶基因突变的影响：同型半胱氨酸尿症新型治疗策略的研究
Tomas Majtan,Ela Mijatovic,Maria Petrosino
Tomas Majtan
Protein misfolding and conformational instability drive protein conformational disorders, causing either accelerated degradation and loss-of-function, as in inherited metabolic disorders like lysosomal storage disorders, or toxic aggregatio...
HEB Restrains Effector Gene Expression during Early CD8+ Memory Precursor T Cell Differentiation [0.03%]
HEB在早期CD8⁺记忆前体T细胞分化过程中限制效应基因的表达
Joanne Pui-Ting Leung,Siamak Haddadi,Michael J Geuenich et al.
Joanne Pui-Ting Leung et al.
Memory T cells are essential for maintaining long-term adaptive immunity. Memory cell precursors and short-lived effector cells emerge from undifferentiated naïve T cells directly downstream of TCR signaling but little is known about how t...
Liver Receptor Homolog-1 Deficiency Impairs Alcohol-Associated Liver Disease Owing to Decrease of Aldehyde Dehydrogenase 1 Family Member B1 Gene Expression [0.03%]
肝受体同源物-1缺乏通过降低醛脱氢酶1家族成员B1基因表达而削弱酒精相关性肝病
Min-Hee Seo,Jae-Ho Lee,Eun-Ho Lee et al.
Min-Hee Seo et al.
Ethanol is detoxified in the liver, and its intake causes hepatic lipid accumulation. The liver receptor homolog-1 (LRH-1) regulates lipid and bile acid metabolism, but its role in ethanol metabolism remains unclear. This study aimed to exp...
An Intrinsically Disordered Region of the FACT Subunit, Spt16, Promotes Chromatin Disassembly in Stimulating the Pre-Initiation Complex Formation at the Promoter for Transcription Initiation In Vivo [0.03%]
染色质拆卸在体内促进转录起始位点pre-initiation复合体的形成中FACT亚基Spt16内在无序区域的作用
Priyanka Barman,Sukesh R Bhaumik
Priyanka Barman
Previous structural and biochemical studies revealed that a negatively charged intrinsically disordered region (IDR) at the C-terminal of the Spt16 subunit of an evolutionarily conserved heterodimeric histone chaperone, FACT (Facilitates ch...
ALYREF Promotes Progression of Intrahepatic Cholangiocarcinoma through Increasing the Level of Isocitrate Dehydrogenase 1 in an m5C-Dependent Manner [0.03%]
ALYREF通过m5C依赖的方式增加异柠檬酸脱氢酶1的水平促进肝内胆管癌进展
Zhiqiang Hao,Haixiang Yang,Wei Zhu et al.
Zhiqiang Hao et al.
RNA 5-methylcytosine (m5C) modification has emerged as an important regulatory mechanism in the progression of human cancers, including hepatobiliary tumors. The m5C "reader" Aly/REF export factor (ALYREF) was recently found to be identifie...
Elevated Type I Interferon Signaling Defines the Proliferative Advantage of ARF and p53 Mutant Tumor Cells [0.03%]
增高的I型干扰素信号通路使ARF和p53突变的肿瘤细胞获得生长优势
Alex Mabry,Catherine E Kuzmicki,Angelina O&#x;Brien et al.
Alex Mabry et al.
The tumor suppressors p53 and ARF collaborate to prevent unwarranted cell proliferation and as such are two of the most frequently mutated genes in human cancer. Concomitant loss of functional p53 and ARF leads to massive gains in cell prol...
Rui Zhang,Marc A Vooijs,Tom Gh Keulers
Rui Zhang
Lysosomes are organelles that play pivotal roles in macromolecule digestion, signal transduction, autophagy, and cellular homeostasis. Lysosome instability, including the inhibition of lysosomal intracellular activity and the leakage of the...
Protein Phosphatase 1 Regulatory Subunit PNUTS Prevents CENP-A Mislocalization and Chromosomal Instability [0.03%]
蛋白磷酸酶1调节亚基PNUTS防止CENP-A错定位和染色体不稳定
Vinutha Balachandra,Makenzie Thomas,Roshan L Shrestha et al.
Vinutha Balachandra et al.
Chromosomal instability (CIN), a major hallmark of cancer, can be driven by defects in the integrity of centromere or kinetochore structure. Coordinated control of phosphorylation and dephosphorylation activities during cell division is cri...
Noncoding RNA, ncRNA-a3, Epigenetically Regulates TAL1 Transcriptional Program During Erythropoiesis [0.03%]
非编码RNA ncRNA-a3在红细胞生成过程中表观遗传调节TAL1转录程序
Meghana Matur,Yasin Uzun,Xiangguo Shi et al.
Meghana Matur et al.
Hematopoietic transcription is a combinatorial control of transcription factors, chromatin modifiers, and non-coding RNAs. TAL1 is a critical regulator of normal and malignant hematopoiesis. However, mechanism underlying regulation of TAL1 ...
Investigating the Aggregation and Prionogenic Properties of Human Cancer-Related Proteins [0.03%]
人类癌症相关蛋白的聚集和朊性属性的研究
Dustin Goncharoff,Zhiqiang Du,Shriram Venkatesan et al.
Dustin Goncharoff et al.
Cancer encompasses a range of severe diseases characterized by uncontrolled cell growth and the potential for metastasis. Understanding the mechanism underlying tumorigenesis has been a central focus of cancer research. Self-propagating pro...