Sinomenine Ameliorates Mitochondrial Dysfunction in PD-1 Inhibitor-Induced Myocardial Injury in Mice via the TLR4/NF-κB Pathway [0.03%]
蔓荆碱通过TLR4/NF-κB途径改善PD-1抑制剂诱导的小鼠心肌损伤中的线粒体功能障碍
Mengjiao Gao,Xinya Liu,Li Wu et al.
Mengjiao Gao et al.
Immune checkpoint inhibitors (ICIs) are widely used in cancer treatment but can cause severe cardiotoxicity. Anti-inflammatory and cardioprotective effects of sinomenine have been documented in existing research. However, it remains unclear...
dif-XerCD is Required for Chromosome Segregation During cSDR-Dependent Growth in Escherichia coli [0.03%]
dif-XerCD 原位重组系统参与调控黏质酸盐可诱导的cSDR-依赖性分裂生长期细菌染色体的精确分离
Taku Tanaka,Rino Fukatsu,Yumika Seki et al.
Taku Tanaka et al.
Escherichia coli cells can grow in a DnaA- and oriC-independent manner in rnhA-deficient cells that lack the major RNaseH activity. This mode of replication is named cSDR (constitutive stable DNA replication) and is believed to initiate fro...
Targeting Ubiquitinated Protein Aggregates in Neurodegenerative Diseases: current Status and Future Directions [0.03%]
神经退行性疾病中靶向泛素化蛋白聚集体的现状和未来方向
Masahiko Takahashi,Takayuki Abe,Masahiro Fujii
Masahiko Takahashi
Various cellular stressors inhibit translation initiation and promote ribosome disassembly, thereby transiently inducing stress granules (SGs), dynamic ribonucleoprotein condensates that contain mRNAs and RNA-binding proteins. Although SG a...
Global Profiling of Remodeled Subcellular Structures Due to Drug Treatment and Disease [0.03%]
药物治疗和疾病引起的重塑的亚细胞结构的全局分析
Rachel A Victor,Jesse J Altemus,Michelle A Lay et al.
Rachel A Victor et al.
Cellular biochemistry arises from various interactions between macromolecules, including proteins, nucleic acids, and lipids. These make up membrane-bound organelles, membrane-less compartments, and molecular assemblies and scaffolds. Chang...
Frequent Functional Orthology of Characterized Long Noncoding RNAs and Genomic Loci Associated with Complex Traits and Disorders [0.03%]
已知长链非编码RNA和与复杂性状及疾病相关的基因组位点频繁具有功能同源性
Mitchell J Cummins,John S Mattick
Mitchell J Cummins
Genome wide association studies (GWAS) have identified many haplotype blocks linked to a wide range of complex human traits, including intelligence, neuropsychiatric disorders, and immunological disorders, among many others. Approximately a...
So Masaki,Takayuki Nojima,Takako Oshiro-Ideue et al.
So Masaki et al.
Pyruvate kinase M (PKM) catalyzes the conversion of phosphoenolpyruvate to pyruvate in glycolysis and exists as two splice isoforms, PKM1 and PKM2, generated from alternative splicing of mutually exclusive exons 9 or 10, respectively. The e...
The Emerging Role of mTOR in Shaping the Cancer Cell Secretome and Plasticity [0.03%]
mTOR在塑造癌细胞分泌组和可塑性中的作用不容忽视
Tyler T Cooper,Ivan Topisirovic,Lynne M Postovit
Tyler T Cooper
As tumors expand and encounter hypoxia and nutrient deprivation, cancer cells must establish tight coordination between metabolic reprogramming, protein synthesis and secretory activity to enable effective adaptation. The mechanistic target...
KLF11 in Extracellular Vesicles Derived from adMSCs Inhibits Colorectal Cancer via Suppressing SOAT1-Mediated Lipogenesis [0.03%]
来源于adMSCs的外泌体中的KLF11通过抑制SOAT1介导的脂质生成抑制结直肠癌
Fan Yang,Haitao Yu,Jian Ni et al.
Fan Yang et al.
Colorectal cancer (CRC) remains one of the most frequently diagnosed and lethal malignancies. Recent studies showed that either adipose-derived mesenchymal stem cells (adMSCs) or the extracellular vesicles (EVs) they secrete retarded CRC pr...
ZRANB1 and ACSS2 Cooperate to Regulate Ubiquitination and Acetylation to Stabilize TWIST1 in Breast Cancer Metastasis [0.03%]
ZRANB1和ACSS2协作调节泛素化和乙酰化以稳定乳腺癌转移中的TWIST1蛋白质
Yeqing Xu,Liufang Zhou,Dizheng Liao et al.
Yeqing Xu et al.
The epithelial-mesenchymal transition (EMT) transcription factor TWIST1 plays a critical role in breast cancer progression. This study reveals that TWIST1 acetylation, which is elevated in metastatic breast cancer tissues, is regulated by a...
Gasdermin D Inhibition Attenuates Mitochondrial Damage and Cardiomyocyte Pyroptosis in Heart Failure with Preserved Ejection Fraction [0.03%]
gasdermin D 抑制减轻射血分数保留心力衰竭的心肌细胞线粒体损伤和细胞焦亡
Linlin Chen,Zhiming Jiang,Cheng Li et al.
Linlin Chen et al.
Heart failure with preserved ejection fraction (HFpEF) represents the most prevalent subtype of heart failure globally, with its underlying pathogenesis remaining incompletely elucidated. Pyroptosis and mitochondrial dysfunction have been i...