Aberrant Expression of miR-25-3p/EZH2 Is Involved in T Cell Activation in Aplastic Anemia [0.03%]
miR-25-3p/EZH2异常表达参与再生障碍性贫血T细胞活化
Jian Gao,Ping Li,Huanyu Guo et al.
Jian Gao et al.
This research aims to investigate how aberrantly expressed miR-25-3p and EZH2 regulate T cell activation in aplastic anemia (AA) patients and to explore the underlying mechanisms. The study enrolled 26 severe AA (SAA) patients and 22 health...
Characterization of the m6A Epitranscriptome in Fibroblast Senescence [0.03%]
人成纤维细胞衰老过程中m6A表转录组的特征分析
Kotb Abdelmohsen,Nirad Banskota,Martina Rossi et al.
Kotb Abdelmohsen et al.
A critical developmental process affecting aging and age-associated disease, cell senescence is characterized by persistent growth arrest and adaptive gene expression patterns. A common RNA modification, N6-methyladenosine (m6A), regulates ...
Insights into FACT in Cancers with Targeted Therapeutic Implications [0.03%]
具有靶向治疗意义的癌症中FACT的功能和机制研究见解
Priyanka Barman,Sukesh R Bhaumik
Priyanka Barman
Facilitates chromatin transcription (FACT) is an evolutionarily conserved chromatin remodeling factor. It controls chromatin states in an ATP-independent manner via the regulation of chromatin assembly and disassembly. Through such regulati...
Human lncRNA, hLinfRNA7 (IDO1-AS) Regulates Cytokine Expression, Tryptophan Catabolism, and Inflammatory Response in Macrophage [0.03%]
人类长链非编码RNA hLinfRNA7（IDO1-AS）调节巨噬细胞中的细胞因子表达，色氨酸分解代谢和炎性反应
Ashcharya Rishi,Prarthana Guha,Nagashree Bhat et al.
Ashcharya Rishi et al.
Noncoding RNAs are emerging players in cell signaling and diseases. Recently, we discovered a series of novel lncRNAs that are critical players in inflammation. Here, we demonstrate that hLinfRNA7, a long human noncoding inflammation-associ...
mTORC1-Dependent Regulation of the CCL24-CCR3 Axis Controls Granuloma Formation and Maintenance in Sarcoidosis [0.03%]
mTORC1调节CCL24-CCR3轴控制肉芽肿形成和 sarcoidosis 中肉芽肿维持的作用机制研究
Xiongjian Rao,Jinpeng Liu,Derek B Allison et al.
Xiongjian Rao et al.
Sarcoidosis is a chronic granulomatous disease marked by persistent inflammation and immune cell aggregation, yet its molecular underpinnings remain incompletely understood, hindering the development of effective targeted therapies. Here, w...
The Novel Compound SIC-19 Triggers CUL4B-Mediated Ubiquitination and Degradation of SIK2 [0.03%]
新型化合物SIC-19通过CUL4B介导的SIK2泛素化降解发挥抗肿瘤作用
Yeqiu Zou,Jiaqi Liu,Shunpeng Zhu et al.
Yeqiu Zou et al.
Small-molecule inhibitors represent a novel potential therapeutic for tumors. Our previous work identified SIC-19, a small molecule compound that induces degradation of salt-inducible kinase 2 (SIK2), leading to apoptosis and reduced prolif...
A Novel Emerin/Nesprin-3 Interaction Mediates Nuclear Size Changes Induced by Oncogenic KRAS in Pancreatic Cancer Cells [0.03%]
致癌KRAS诱导的胰腺癌细胞核大小改变通过新型emerin/Nesprin-3相互作用介导
Kayla C LaRue-Nolan,Luis F Flores,Renzo E Vera et al.
Kayla C LaRue-Nolan et al.
Nuclear envelope (NE) proteins are essential for maintaining nuclear morphology, a central process controlling cellular phenotypes. While these proteins and structures are largely characterized in developmental biology, their function and a...
The Yeast AP-1 Factor Yap8 Recruits SAGA and SWI/SNF to Regulate ACR3 Expression and Arsenic Tolerance [0.03%]
酿酒酵母AP-1因子Yap8通过募集SAGA和SWI/SNF复合体调节ACR3表达及砷耐受性
Ewa Maciaszczyk-Dziubinska,Antonia M Romero,Nallani Vijay Kumar et al.
Ewa Maciaszczyk-Dziubinska et al.
The AP-1-like protein Yap8 is required for arsenic tolerance in the yeast Saccharomyces cerevisiae. Previous work has shown that Yap8 binds to arsenic via critical cysteine residues, which converts Yap8 into an active transcriptional regula...
Correction [0.03%]
改正
Published Erratum
Molecular and cellular biology. 2026 May 21:1-5. DOI:10.1080/10985549.2026.2672906 2026
Pharmacological Inhibition of Valosin-Containing Protein (VCP) Triggers Cardiac Hypertrophy and Heart Failure in Vivo [0.03%]
药物抑制含瓦尔松蛋白(VCP)触发在 vivo心脏肥大和心力衰竭
Federica Diofano,Benedict Allhoff,Deung-Dae Park et al.
Federica Diofano et al.
Valosin-containing protein (VCP) is a crucial ATPase involved in maintaining protein homeostasis through the ubiquitin-proteasome system (UPS) and endoplasmic reticulum-associated degradation (ERAD). Dysregulation of VCP has been implicated...