A Mutation in the RNA-Binding Protein Cth2 Limits the Adaptation of a Subset of Wild Saccharomyces cerevisiae Yeast Strains to Iron Deficiency [0.03%]
一种RNA结合蛋白Cth2的突变限制了一部分野生酿酒酵母菌株适应铁缺乏的能力
Elena Valera-García,Raquel Sorribes-Dauden,Sergi Puig
Elena Valera-García
Iron is an essential micronutrient for eukaryotic organisms. In response to iron deficiency, the yeast Saccharomyces cerevisiae optimizes iron utilization by downregulating nonessential iron-dependent processes, such as mitochondrial respir...
Loss of Function Mouse Models Reveal a Novel Regulatory Function for ULK1 in Myeloproliferative Neoplasms [0.03%]
无功能小鼠模型揭示了ULK1在髓系增生性肿瘤中的新调控作用
Diana Saleiro,Jeremy Q Wen,Markella Zannikou et al.
Diana Saleiro et al.
Defining the mechanisms that promote development and progression of myeloproliferative neoplasms (MPNs) is important for understanding the mechanisms of malignant hematopoiesis and critical development of new treatment approaches. We provid...
Molecular Function of Midnolin and Its Relevance to Parkinson's Disease [0.03%]
Midnolin的分子功能及其与帕金森病的关系
Yutaro Obara,Ayano Chiba
Yutaro Obara
Midnolin (Midn) was originally discovered as a gene expressed specifically in the mouse midbrain at the embryonic developmental stage; MIDN was localized in the nucleus/nucleolus. Although the pathophysiological roles of MIDN remained large...
miR-365-3p Regulates Gastrointestinal Dysfunction in Diabetes Mellitus Rats via the TLR4/MyD88/NF-κB Pathway [0.03%]
miR-365-3p通过TLR4/MyD88/NF-κB通路调节糖尿病大鼠胃肠功能障碍
Jiao Xiao,Bin Gao,Yan Xiao et al.
Jiao Xiao et al.
Over half of diabetes mellitus (DM) patients suffer from gastrointestinal motility disorders. miR-365-3p is involved in DM progression, but its role in gastrointestinal motility disorders remains unclear. This study explored whether miR-365...
The Ubiquitin E3 Ligase UBE3A Regulates GRIPAP1 and PACSIN1 Proteins Linked to the Endocytic Recycling of AMPA Receptors [0.03%]
泛素蛋白酶UBE3A调节与AMPA受体内吞循环有关的GRIPAP1和PACSIN1蛋白质
Laura Drebushenko,Natalya Belous,Fritz W Lischka et al.
Laura Drebushenko et al.
Angelman syndrome (AS) is a neurodevelopmental disorder characterized by cognitive and language impairments, seizures, reduced or fragmented sleep, motor ataxia, and a characteristic happy affect. AS arises due to the neuronal loss of UBE3A...
MARBP-lncRNA Complexes Alter Gene Function Through Modulation of Epigenetic Landscape [0.03%]
染色质构象重构复合物通过调节表观遗传景观来改变基因功能
Nilanjana Maji,Anindya Dutta,Animesh Anand et al.
Nilanjana Maji et al.
Chromatin structure in eukaryotes is organized into functional domains through protein-DNA complexes. The cis-acting DNA elements are attached to the nuclear matrix, known as scaffold/matrix attachment regions (S/MARs). The associated prote...
Hypoxia Signaling in the Cell Type-Specific Regulation of Erythropoietin Production Throughout Mammalian Development [0.03%]
低氧诱导生成促红细胞生成素的信号通路及其在哺乳动物发育过程中各种细胞类型中特异性的调节作用
Norio Suzuki,Taku Nakai,Yuma Iwamura et al.
Norio Suzuki et al.
To maintain the oxygen supply to peripheral organs, the production of erythropoietin (EPO), an essential growth factor for red blood cells, is controlled in a hypoxia-inducible manner in mammals. The developmentally earliest site of EPO pro...
Differential Transcriptional Activity of ΔNp63β Is Encoded by an Isoform-Specific C-Terminus [0.03%]
ΔNp63β的转录活性差异由特异性的C末端编码而来
Abby A McCann,Morgan A Sammons
Abby A McCann
p63 is a clinically relevant transcription factor heavily involved in development and disease. Mutations in the p63 DNA-binding domain cause severe developmental defects and overexpression of p63 plays a role in the progression of epithelia...
Anna E Enneking,Marc M Khorey,Laura E Edgington-Mitchell
Anna E Enneking
While the cysteine proteases legumain and cathepsins have traditionally been known as "lysosomal" proteases, there is increasing evidence to suggest that they also contribute to a wide range of extralysosomal processes, including in the nuc...
Identification of a Novel Intracellular Function of the Secreted Ribonuclease RNASE1 in Inhibiting Gene Expression [0.03%]
分泌型核糖核酸酶RNASE1的胞内功能鉴定：抑制基因表达作用
Ragini Singh,Ahlina Archibald,Xiao Ling Li et al.
Ragini Singh et al.
RNASE1 is a ribonuclease secreted by cells and degrades extracellular RNAs. Here, we unexpectedly found that RNASE1, in addition to being secreted, is predominantly localized to the nucleus and functions to inhibit gene expression in human ...