Loss of E-Cadherin Alters Cigarette Smoke Extract (CSE)-Induced Damage and Repair Responses in Human Airway Epithelial Cells; Implications for Chronic Obstructive Pulmonary Disease (COPD) [0.03%]
E-钙黏着蛋白丢失改变人支气管上皮细胞中烟草烟雾提取物诱导的损伤和修复反应；对慢性阻塞性肺病的意义
Xinzi Zheng,Kingsley Okechukwu Nwozor,Marnix Jonker et al.
Xinzi Zheng et al.
COPD is characterized by airway epithelial barrier dysfunction. We hypothesized that downregulation of E-cadherin results in abnormal responses to cigarette smoke extract (CSE) with impaired repair and increased pro-inflammatory activity. W...
Site Specific and Orientation Dependent CTCF Binding Determines VDJ Recombination at Murine Tcrb Locus [0.03%]
特定位点和取向依赖的CTCF结合决定小鼠Tcrb位点VDJ重组
Monika Yadav,Samriddhi Sharma,S R Rajalekshmi et al.
Monika Yadav et al.
CTCF is a multifunctional protein that mediates long-range cis-DNA interactions in mammalian genomes. Chromatin architecture governs spatial and functional interactions of gene regulatory elements at various loci and is impacted by the abil...
Lactate as an Exercise Mimetic: Mitigating Disuse Atrophy and Improving Muscle Endurance in Aging SAMP8 Mice [0.03%]
乳酸作为运动模拟物对改善SAMPM小鼠骨骼肌横截面积和耐力的作用研究
Zhen Qi,Xi Liu,Yifen Chen et al.
Zhen Qi et al.
Lactate, historically considered a metabolic byproduct, has emerged as a key regulator of muscle physiology and metabolism. This study explores its potential as an exercise mimetic to counteract disuse muscle atrophy (DMA) in aging skeletal...
Histone Acetyltransferases Gcn5 and Esa1 Regulate Occupancy of RSC to Maintain Nucleosome-Depleted Regions and Promote RSC Recruitment to Coding Regions Genome-Wide in Saccharomyces cerevisiae [0.03%]
组蛋白乙酰转移酶Gcn5和Esa1调控RSC的驻留以维持染色质上的无核小体区并促进酵母基因组上RSC募集到编码区
Emily Biernat,Mansi Verma,Matthew Werick et al.
Emily Biernat et al.
Chromatin remodelers are important for maintaining chromatin structure and regulating gene expression. In this study, we investigated the roles of histone acetyltransferases (HATs) Gcn5 and Esa1 in regulating RSC and histone occupancy on ch...
PARP1-Dependent and Independent Pathways for Resolution of Trapped Topoisomerase I Covalent Complexes [0.03%]
依赖 PARP1 和独立于 PARP1 的捕获型拓扑异构酶I共价复合物的解离途径
Benu Brata Das,Banhi Chowdhury,Sarita Das et al.
Benu Brata Das et al.
Topoisomerase I (Top1) alleviates DNA supercoiling during replication and transcription, but its catalytic cycle can be hijacked by chemotherapeutic agents such as camptothecin (CPT), stabilizing Top1-DNA covalent complexes (Top1cc) that th...
Acyl-CoA Reductase Far1 Deficiency Impairs Ether Lipid Production and Hypomyelination in Mouse Brains [0.03%]
脂肪酰基辅酶A还原酶Far1缺陷损害小鼠脑醚脂生成和少髓鞘形成
Tenga Takahashi,Kento Otsuka,Takayuki Sassa et al.
Tenga Takahashi et al.
Mammalian cell membranes contain ether lipids, which include an alkyl chain derived from a fatty alcohol that is produced by fatty acyl-CoA reductases (FARs). There are two mammalian FAR genes, FAR1 and FAR2, and mutations in FAR1 cause the...
Immune Regulation of Itaconate and Its Derivatives in Liver Diseases [0.03%]
丁酸盐通过诱导产生IL-10的调节性NK细胞减轻NASH炎症
Tianning Ge,Yifei Zhang
Tianning Ge
Over the past few decades, liver disease has emerged as one of the leading causes of death worldwide. Liver injury is frequently associated with infections, alcohol consumption, or obesity, which trigger hepatic inflammation and ultimately ...
Molecular Insights into the Pathophysiology of Dysregulated Erythropoiesis: The Crucial Role of Iron Homeostasis [0.03%]
红细胞生成紊乱的病理生理学的分子见解：铁稳态的关键作用
Tohru Fujiwara,Hideo Harigae
Tohru Fujiwara
Erythropoiesis, i.e., process of red blood cell (RBC) production, is highly dependent on iron, with 60-70% of the total body iron incorporated into hemoglobin. Iron homeostasis is tightly regulated, given that both iron overload and deficie...
Manish Kumar,Ioannis Grammatikakis
Manish Kumar
Alternative splicing is a major player in post-transcriptional gene regulation leading to transcript variant and protein isoform diversity. Intron retention (IR) is a type of alternative splicing resulting in inclusion of sequences in matur...
Net1 Controls Src Activation to Regulate Breast Cancer Cell Motility and Invasion [0.03%]
Net1通过调控Src活化来调节乳腺癌细胞迁移和侵袭
Yan Zuo,Heather S Carr,Wen Li et al.
Yan Zuo et al.
The cytoplasmic tyrosine kinase Src supports many phenotypes in cancer cells, including proliferation, migration and invasion, survival, and metastasis. We have previously shown that Src promotes cytoplasmic localization of the RhoGEF Net1,...