Cholesterol Transport from ER to Outer Mitochondria by ERLIN2 in Steroid Metabolism [0.03%]
胆固醇通过ERLIN2从内质网运输到线粒体外膜以促进类固醇代谢
Himangshu S Bose,William E Burak Jr,Randy M Whittal
Himangshu S Bose
Cholesterol trafficking from the endoplasmic reticulum (ER) through the mitochondria-associated ER membrane (MAM) and finally to mitochondria is essential for mammalian survival. ER lipid raft-associated protein 2 (ERLIN2) scaffolds raft-li...
Correction [0.03%]
改正
Published Erratum
Molecular and cellular biology. 2025 Nov 14:1-3. DOI:10.1080/10985549.2025.2578939 2025
Low-Dose Caffeine Exposure Protects the Human Genome from Ionizing Radiation-Induced Damage and Prolongs Mouse Longevity [0.03%]
低剂量咖啡因暴露保护人类基因组免受电离辐射诱导的损伤并延长小鼠寿命
Susmita Kumari,Supriya V Vartak,Sabita Tamang et al.
Susmita Kumari et al.
Coffee is one of the most widely consumed beverages in the world and is a rich source of caffeine, a methylxanthine. Here we show that exposure to caffeine significantly reduces ionizing radiation (IR) induced DNA breaks and resulted in no ...
Pharmacological Modulation of Autophagy Corrects Cellular Defects in Pediatric Crohn's Disease [0.03%]
药理学调节自噬可纠正儿童克罗恩病的细胞缺陷
Mara Creoli,Pietro Buono,Sabrina Cenni et al.
Mara Creoli et al.
Crohn's disease (CD) is an inflammatory gastrointestinal disorder marked by impaired autophagy due to inefficient bacterial uptake. We studied the effects of autophagy modulation using Tat-beclin-1 and carbamazepine (CBZ) on dendritic cells...
From Genome Guardian to Immune Modulator: The Expanding Roles of Tumor Suppressor p53 [0.03%]
从基因组守护者到免疫调节因子—肿瘤抑制蛋白p53的多重作用机制
Weiwei Wang,Juan Liu,Zhaohui Feng et al.
Weiwei Wang et al.
p53 is a key tumor suppressor, and mutations in the p53 gene occur in more than half of all human cancers. p53, which is under tight and complex regulation in cells, functions primarily as a transcription factor regulating genes involved in...
From Biogenesis to Breakdown: How Protein Biogenesis and Quality Control Failures Drive Mitochondrial Disease [0.03%]
从生物发生到分解：蛋白质生物发生和质量控制失败如何驱动线粒体疾病
Phoebe J Leeming,Julia Mercuri-Svik,Diana Stojanovski
Phoebe J Leeming
Mitochondria rely on the coordinated function of over 1000 proteins, most of which are nuclear-encoded, synthesized in the cytosol, and imported into distinct mitochondrial sub-compartments. Thirteen additional proteins are synthesized with...
Metabolic Regulation of Copper Homeostasis Governs the Sec61-Dependent Protein Translocation Process in Saccharomyces cerevisiae [0.03%]
铜稳态的代谢调控决定了酿酒酵母中Sec61依赖性的蛋白质转运过程
Vandana Anjana,Smriti Anand,Prateeksha Thakur et al.
Vandana Anjana et al.
The concentration of cellular labile pool of copper must be strictly regulated because disruption in copper homeostasis results in diseases. In Saccharomyces cerevisiae, elevated levels of labile copper impair cell viability by inhibiting S...
The Role of Tumor-Intrinsic HuR in Modeling the Pancreatic Tumor Microenvironment: Molecular Mechanisms and Therapeutic Opportunities [0.03%]
肿瘤固有的HuR在胰腺肿瘤微环境建模中的作用：分子机制和治疗机会
Katherine R Pelz,Kyle P Gribbin,Tess Sevetson et al.
Katherine R Pelz et al.
Pancreatic ductal adenocarcinoma (PDAC) remains largely refractory to therapy, due in part to the complex interplay between tumor cells and their microenvironment. Human antigen R (HuR/ELAVL1), a ubiquitously expressed RNA-binding protein, ...
Deciphering the m6A Epitranscriptomic Landscape of mRNAs in Breast Cancer Cells [0.03%]
解析乳腺癌细胞中mRNA的m6A表转录组景观
Konstantina Athanasopoulou,Panagiotis G Adamopoulos,Panagiotis Tsiakanikas et al.
Konstantina Athanasopoulou et al.
N6-methyladenosine (m6A), the most prevalent modification in mRNAs, influences mRNA stability, splicing, and translation. Dysregulation of m6A patterns has been linked to various diseases, including cancer, highlighting its significance in ...
Effects of DNA Methylation Inhibitors on Molecular and Structural Changes in Chromatin Organization in Leukemia Cells [0.03%]
DNA甲基化抑制剂对白血病细胞染色质组织的分子和结构改变的影响
Przemysław Sareło,Aleksandra Kaczorowska,Marlena Gąsior-Głogowska et al.
Przemysław Sareło et al.
DNA methylation inhibitors are widely used in treating myeloid malignancies, yet their precise effects on chromatin organization and nuclear architecture remain incompletely understood. Here, the integrated molecular, cellular, and biophysi...