Enhanced ELL Phase Separation Is Crucial for Efficient DNA Damage Repair to Restart Transcription and Cell Survival [0.03%]
增强型ELL相分离对于有效DNA损伤修复以重启转录和细胞存活至关重要
Sujay Pal,Prathama Talukdar,Arijit Ghosh et al.
Sujay Pal et al.
During genotoxic stress, mammalian cells adapt to resume transcription after repair of damaged DNA. However, mechanisms of these adaptations leading to optimal transcriptional restart are poorly known. In this study, we show critical role o...
Cancer-Associated DAXX Mutations Reveal a Critical Role for ATRX Localization in ALT Suppression [0.03%]
DAXX突变体揭示了ATRX定位在ALT抑制中的关键作用
Sarah F Clatterbuck Soper,Robert L Walker,Marbin A Pineda et al.
Sarah F Clatterbuck Soper et al.
To maintain genome stability, proliferating cells must enact a program of telomere maintenance. While most tumors maintain telomeres using telomerase, a subset of tumors utilize a DNA-templated process termed alternative lengthening of telo...
PIH1D1 and RPAP3, Components of the PAQosome: Emerging Roles in Cellular Physiology [0.03%]
PAQesome成分PIH1D1和RPAP3：在细胞生理中的新兴作用
Mahaiwon Shadang,Riyaz Ahmad Mir
Mahaiwon Shadang
The PAQosome (R2TP/PFDL complex) is a recently characterized co-chaperone of Hsp90 that orchestrates the assembly and stabilization of diverse macromolecular protein complexes essential for cellular homeostasis. It consists of RUVBL1, RUVBL...
Deletion of Adaptor Protein ShcD Impairs Olfactory Bulb Morphology and Function [0.03%]
凋 adaptor 蛋白 ShcD 缺失影响嗅球形态和功能
Hannah N Robeson,Laura A New,Begüm Alural et al.
Hannah N Robeson et al.
Shc family adaptor proteins are involved in diverse signaling pathways that regulate critical cellular functions, including proliferation, differentiation, migration, and survival. ShcD is the most recently isolated member and while previou...
Dual Regulatory Roles of USP10 in Tau Pathology and Neuronal Fate During Alzheimer's Disease Progression [0.03%]
USP10在阿尔茨海默病进展过程中对tau病理和神经元命运的双重调控作用
Masahiko Takahashi,Hiroki Kitaura,Asa Nakahara et al.
Masahiko Takahashi et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by neuronal cell death, brain atrophy, and cognitive decline. Aggregation of Tau protein in neurons is a critical factor in the pathogenesis of AD. Tau aggre...
Silybin Improves Acute Kidney Injury by Regulating HDAC6/NF-κB/NLRP3 Signaling to Reduce Inflammation and Ferroptosis [0.03%]
通过调节HDAC6/NF-κB / NLRP3信号通路减轻炎症和铁死亡改善急性肾损伤_silybin抗氧化作用机制研究
Ying Wei,Mingjing Yin,Guojiang Chen et al.
Ying Wei et al.
Inflammation and ferroptosis play a crucial role in cisplatin (CP)-induced acute kidney injury (AKI). Silybin (SYB), a polyphenolic flavonoid, has shown renal protective effects, but its underlying mechanisms remain unclear. CP-induced HK-2...
Distinct Functions of the Tor1 and Tor2 Kinases in Regulation of the Ribosomal Protein Gene Expression via TORC1, Not TORC2 [0.03%]
Tor1和Tor2激酶通过TORC1而非TORC2调节核糖蛋白基因表达的不同的功能
Amala Kaja,Bhawana Uprety,Pritam Chakraborty et al.
Amala Kaja et al.
The serine/threonine kinase, TOR (target of rapamycin), exists in two complexes, namely TORC1 (with either Tor1 or Tor2 kinase) and TORC2 (that contains Tor2, but not Tor1), and its pharmacological inhibition by rapamycin impairs the PIC (p...
Schizosaccharomyces pombe Telomerase RNA: Secondary Structure and Flexible-Scaffold Function [0.03%]
裂殖酵母端粒酶RNA：二级结构及其作为空间框架的作用
Karen McMurdie,Allison N Peeney,Melissa A Mefford et al.
Karen McMurdie et al.
The telomerase RNA-protein enzyme is critical for most eukaryotes to complete genome copying by extending chromosome ends, thus solving the end-replication problem and postponing senescence. Despite the importance of the fission yeast Schiz...
Qi Lian Jie Ning Ameliorates DSS-Induced Colitis in Rats by Inhibition of JAK2/STAT3 and TLR4/NF-kB Pathways [0.03%]
秦建宁方通过抑制JAK2/STAT3和TLR4/NF-κB信号通路改善DSS诱导的结肠炎
Jinyang Hu,Songlin Zeng,Shisheng Jiang et al.
Jinyang Hu et al.
Ulcerative colitis (UC) is a clinically common idiopathic inflammatory bowel disease. The DSS-induced colitis model was induced via 5% DSS for 7 days. Rats were gavaged with QLJCN solution in different concentrations. This study measured bo...
Recent Insights into Mechanisms Regulating the Proteasome: Implications for Human Disease [0.03%]
调控蛋白酶体机制的最新见解及其对人类疾病的影响
Rintaro Sumikama,Yuri Shibata,Rihan Wu et al.
Rintaro Sumikama et al.
Since its discovery several decades ago, the proteasome has been recognized as one of the most complex and highly evolved proteolytic systems. Through the selective and rapid degradation of ubiquitinated proteins, it plays a pivotal role in...