TRF-1 Mediates PRC2 Function at Ectopic Telomere Repeats in Neurospora crassa [0.03%]
TRF-1介导了Neurospora crassa中异位端粒重复序列处PRC2的功能
Colleen C Mumford,Peregrine D Painter,Kevin J McNaught et al.
Colleen C Mumford et al.
Telomeres are crucial for maintaining chromosomal integrity and are characterized by repetitive DNA sequences, which may be stabilized by the shelterin protein complex or by formation of secondary structures, such as G-quadruplexes (G4 DNA)...
The Copper Chaperone ATOX1 Exhibits Differential Protein-Protein Interactions and Contributes to Skeletal Myoblast Differentiation [0.03%]
铜伴侣ATOX1表现出不同的蛋白质相互作用并参与骨骼肌母细胞分化
Nathan Ferguson,Yu Zhang,Alexandra M Perez et al.
Nathan Ferguson et al.
Copper is an essential but potentially toxic nutrient required for a variety of biological functions. Mammalian cells use a complex network of copper transporters and metallochaperones to maintain copper homeostasis. Previous work investiga...
Molecular Mechanisms of Transcription Factors with Dual Activator and Repressor Functions [0.03%]
兼有激活子和阻遏物功能的转录因子的作用机制
Jinhong Dong,Michael J Guertin
Jinhong Dong
Transcription factors (TFs) are traditionally classified as activators or repressors, yet some can perform both roles. We highlight well-supported examples of dual activator/repressor functions and review the mechanisms that explain how dua...
Impact of Transposable Elements on DNA Double-Strand Break Repair and Genomic Stability [0.03%]
转座元件对DNA双链断裂修复及基因组稳定性的影响
Mohd Iqbal Bhat,Raj K Pandita,Arjamand Mushtaq et al.
Mohd Iqbal Bhat et al.
Transposable elements (TEs) are indispensable components of eukaryotic genomes, mechanistically linked to carcinogenesis, aging and other degenerative diseases. The ability of TEs to self-propagate and cause deletions, inversions or inserti...
Acetylation-Dependent Histone H2AX Exchange Suppresses Pathological Senescence via MDC1 Degradation [0.03%]
乙酰化依赖的组蛋白H2AX交换通过MDC1降解抑制病理性衰老现象
Masae Ikura,Kanji Furuya,Yasunori Horikoshi et al.
Masae Ikura et al.
Cellular senescence has a dual role in both tumor suppression and the promotion of age-related diseases. This paradox suggests the existence of functionally distinct "beneficial" and "detrimental" senescent states, yet the molecular basis t...
How Particular RNA Editing Sites Can be Selectively Superior to Heterozygous SNPs Independent of Temporospatial Regulation [0.03%]
特定的RNA编辑位点如何能够优于杂合SNP并独立于时间空间调控而具有选择优势
Qiuhua Xie,Ling Ma,Wanzhi Cai et al.
Qiuhua Xie et al.
A-to-I RNA editing introduces A-to-G variation at post-transcriptional level, but it remains mysterious. What is the advantage of functional RNA editing compared to an A/G heterozygous SNP? Here, we provide the following situations that par...
Mitochondria and Lipids in Cellular Signaling of the Brain: from Physiology to Neurodegeneration [0.03%]
脑细胞信号传导中的线粒体和脂质：从生理学到神经退行性病变
Plamena R Angelova,Lauren Millichap,Andrey Y Abramov
Plamena R Angelova
The brain is one of the most lipid-rich organs, reflecting the critical role of lipid metabolism in neuronal and glial cell function. While mitochondria are central to energy metabolism, calcium signaling, and cell death, they do not utiliz...
Xiangpi Shengji Ointment Accelerates Anal Fistula Healing by Regulating Macrophage-Fibroblast Crosstalk Through the Nuclear Factor Kappa B/Hypoxia-Inducible Factor Alpha/Vascular Endothelial Growth Factor Signaling Axis [0.03%]
消痞生肌膏通过调控核因子κB/缺氧诱导因子α/血管内皮生长因子信号轴巨噬细胞-成纤维细胞交互作用促进肛瘘愈合
Kui Li,Jiaqing Xiong,Sai Yang et al.
Kui Li et al.
This study elucidates the molecular mechanism by which Xiangpi Shengji ointment (Xiangpi Shengji gao, XPSJG) promotes anal fistula wound healing. Integrated network pharmacology and transcriptomic analyses (GSE28914, GSE203244) revealed the...
The Role the Saccharomyces cerevisiae Nonsense-Mediated mRNA Decay Pathway Plays in Metal Toxin Uptake and Detoxification [0.03%]
酿酒酵母终止密码子介导的mRNA降解途径在金属毒物摄取和排毒中的作用研究
Sunday Olaniyan,Jacqueline Carroll,Stephnie Nwaiwu et al.
Sunday Olaniyan et al.
Regulation of gene expression at the messenger RNA (mRNA) level is crucial for organisms to rapidly respond to changing environmental conditions, especially harmful toxins. The highly conserved nonsense-mediated mRNA decay (NMD) pathway is ...
The Role of the RhoA Activating Protein Net1 in Cancer Initiation and Progression [0.03%]
RhoA活化蛋白Net1在癌症发生和发展中的作用
Yan Zuo,Stephanie A Planque,Jeffrey A Frost
Yan Zuo
Rho GTPases are Ras-like proteins that contribute to many aspects of human cancer. However, unlike Ras, Rho proteins are not often mutagenically activated in cancers, but require activation by upstream proteins known as Rho GDP exchange fac...