Lnc-ing the Hallmarks of Cancer: The Interplay between lncRNAs and the p53 Family Members across the Hallmarks of Cancer [0.03%]
长非编码RNA与p53家族成员在癌症标志物中的相互作用
Avani A Deshpande,John H Lockhart,Marco Napoli et al.
Avani A Deshpande et al.
The fascinating world of long non-coding RNAs (lncRNAs) has expanded significantly over the past two decades, and their characterization has revealed their involvement in a variety of biological processes both in physiological and pathologi...
Hsp70/Hsp90 Organizing Protein (HOP) Maintains CRAF Kinase Activity and Regulates MAPK Signaling by Enhancing Hsp90-CRAF Association [0.03%]
Hsp70/90组织蛋白(HOP)通过增强Hsp90-CRAF相互作用维持CRAF激酶活性并调控MAPK信号通路
Nilanjan Gayen,Sahana Mitra,Somesh Roy et al.
Nilanjan Gayen et al.
The stability and activity of CRAF/Raf1 kinase are stringently regulated by heat shock protein 90 (Hsp90). Hsp90-mediated client folding and maturation are governed by its co-chaperones, but their functionality in chaperoning CRAF kinase to...
Paeonol Ameliorates Gastric Mucosal Enterosis and Dysplasia Associated with Chronic Atrophic Gastritis by Modulating the JAK2/STAT3 Pathway [0.03%]
芍药苷通过调节JAK2/STAT3信号通路改善慢性萎缩性胃炎相关肠上皮化生及不典型增生
Lei Zhang,Lei Zou
Lei Zhang
Paeonol (Pae) exhibits potent anti-inflammatory and antitumor effects. Chronic atrophic gastritis (CAG) is considered a gastric precancerous lesion, and the JAK2/STAT3 pathway plays a key role in gastrointestinal inflammation and tumorigene...
Importance of E3 Ligases for Preserving Genome Integrity: Progress and Challenges [0.03%]
E3连接酶在维护基因组稳定性中的作用：进展与挑战
Rumpa Mahata,Manas Kumar Santra
Rumpa Mahata
Maintenance of genome integrity is crucial for the survival of an organism. However, our genome is constantly being challenged by several processes that cause cellular stress, resulting in chromosomal instability and the onset of diseases l...
Chaihu Shugan Powder Attenuates Ferroptosis-Associated Injury in Acute Pancreatitis by Activating PGC-1α/Nrf2/HO-1 Pathway [0.03%]
柴胡舒肝散通过激活PGC-1α/Nrf2/HO-1信号通路对抗急性胰腺炎相关的铁死亡损伤
Yutao Chen,Dapeng Zhang,Quan Li et al.
Yutao Chen et al.
Acute pancreatitis (AP) is a life-threatening condition driven by premature pancreatic enzyme activation, leading to systemic complications and multi-organ dysfunction. Chaihu Shugan Powder (CSP) has been reported to mitigate pancreatic inj...
Stefano Donega,Myriam Gorospe,Lorna W Harries et al.
Stefano Donega et al.
Alternative splicing is a fundamental mechanism that ensures accurate gene expression, supports cellular adaptability, and expands protein diversity beyond the limits of a fixed gene pool. With aging, splicing fidelity weakens, contributing...
PKM2-DNMT3A-SMAD2 Axis Regulates Cell Proliferation via Histone Lactylation in Breast Cancer [0.03%]
乳腺癌中组蛋白乳酸化调节细胞增殖的PKM2-DNMT3A-SMAD2轴
Abin Sabu,Deepak Pant,Srinivas Abhishek Mutnuru et al.
Abin Sabu et al.
Cancer develops from the unregulated proliferation of cells, influenced by a confluence of genetic mutations and epigenetic modifications that disrupt normal regulatory networks. In recent years, cellular metabolism has emerged as an import...
Systematic Screening via WGCNA, Machine Learning, and Validation Identifies C3 and CFD as Prognostically Significant Regulators in GIST Progression [0.03%]
WGCNA、机器学习和验证的系统筛查识别出补体C3和补体因子D为胃肠道间质瘤进展中的预后重要调节基因
Yuxuan Ma,Xin Liu,Yuhao Wang et al.
Yuxuan Ma et al.
Gastrointestinal stromal tumor (GIST), the most common gastrointestinal mesenchymal neoplasm, remains poorly understood at the molecular level, limiting precise diagnosis and targeted therapy. This study aimed to systematically identify key...
Molecular Mechanisms of RNA Polymerase I Transcription in Health and Disease: An Overview [0.03%]
健康与疾病中的RNA聚合酶I转录的分子机制概述
Bridget M Walker,Jonathan Y Chung,Haleigh G Pascual et al.
Bridget M Walker et al.
RNA polymerase I (Pol I) is a specialized eukaryotic enzyme responsible for transcribing ribosomal DNA into precursor rRNA, a process that initiates ribosome biogenesis and supports cellular growth, metabolism, and proliferation. Recent str...
p62 Coordinates Autophagy, cAMP Signalling, and Cell-Fate Determination in Dictyostelium discoideum [0.03%]
P62在Dictyostelium discoideum中协调自噬、cAMP信号传导和命运决定
Saksham Gautam,Shweta Saran
Saksham Gautam
p62/SQSTM1 is a multifunctional adaptor protein playing a central role in the regulation of autophagy and stress response pathways in higher eukaryotes. However, its functional relevance in lower eukaryotes like Dictyostelium remains largel...