AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2 [0.03%]
AMPK和内皮型一氧化氮合酶信号通过环GMP依赖性蛋白激酶2调节K-Ras胞膜相互作用
Kwang-Jin Cho,Darren E Casteel,Priyanka Prakash et al.
Kwang-Jin Cho et al.
K-Ras must localize to the plasma membrane and be arrayed in nanoclusters for biological activity. We show here that K-Ras is a substrate for cyclic GMP-dependent protein kinases (PKGs). In intact cells, activated PKG2 selectively colocaliz...
Endoplasmic Reticulum Stress Enhances Mitochondrial Metabolic Activity in Mammalian Adrenals and Gonads [0.03%]
内质网应激增强哺乳动物肾上腺和性腺线粒体代谢活性
Manoj Prasad,Anna N Walker,Jasmeet Kaur et al.
Manoj Prasad et al.
The acute response to stress consists of a series of physiological programs to promote survival by generating glucocorticoids and activating stress response genes that increase the synthesis of many chaperone proteins specific to individual...
Human PDCD2L Is an Export Substrate of CRM1 That Associates with 40S Ribosomal Subunit Precursors [0.03%]
人PDCD2L是CRM1的出口底物，与40S核糖体亚基前体相关
Anne-Marie Landry-Voyer,Sarah Bilodeau,Danny Bergeron et al.
Anne-Marie Landry-Voyer et al.
Protein arginine methyltransferase 3 (PRMT3) forms a stable complex with 40S ribosomal protein S2 (RPS2) and contributes to ribosome biogenesis. However, the molecular mechanism by which PRMT3 influences ribosome biogenesis and/or function ...
SIK2 Restricts Autophagic Flux To Support Triple-Negative Breast Cancer Survival [0.03%]
SIK2限制自噬流量以支持三阴性乳腺癌细胞的存活
Kimberly E Maxfield,Jennifer Macion,Hariprasad Vankayalapati et al.
Kimberly E Maxfield et al.
Triple-negative breast cancer (TNBC) is a highly heterogeneous disease with multiple, distinct molecular subtypes that exhibit unique transcriptional programs and clinical progression trajectories. Despite knowledge of the molecular heterog...
Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells [0.03%]
细胞内Nrf2-Keap1-Cul3复合物的绝对含量及其状态
Tatsuro Iso,Takafumi Suzuki,Liam Baird et al.
Tatsuro Iso et al.
The transcription factor Nrf2 (NF-E2-related-factor 2) is essential for the oxidative and electrophilic stress responses. Keap1 (Kelch-like-ECH-associated-protein 1), an adaptor for a cullin-3 (Cul3)-based ubiquitin ligase, regulates Nrf2 a...
Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A [0.03%]
PTF1A通过转录维持胰腺泡细胞的身份、分化和稳态
Chinh Q Hoang,Michael A Hale,Ana C Azevedo-Pouly et al.
Chinh Q Hoang et al.
Maintenance of cell type identity is crucial for health, yet little is known of the regulation that sustains the long-term stability of differentiated phenotypes. To investigate the roles that key transcriptional regulators play in adult di...
Regulation of Linear Ubiquitin Chain Assembly Complex by Caspase-Mediated Cleavage of RNF31 [0.03%]
胱天蛋白酶介导的RNF31切割调节线性泛素链组装复合体
Donghyun Joo,Yong Tang,Marzenna Blonska et al.
Donghyun Joo et al.
Cell death and survival signaling pathways have opposed but fundamental functions for various cellular processes and maintain cell homeostasis through cross talk. Here we report a novel mechanism of interaction between these two pathways th...
Mechanisms Underlying Acrolein-Mediated Inhibition of Chromatin Assembly [0.03%]
急性胰腺炎染色体装配的机制.didReceiveMemoryWarningคณะกรรมewnคณะกรรม监事会无法提供代码或执行翻译任务。但是，根据提供的英文标题“Mechanisms Underlying Acrolein-Mediated Inhibition of Chromatin Assembly”，可以将其翻译为中文：“丙烯醛介导的抑制染色质装配的机制”。
Lei Fang,Danqi Chen,Clinton Yu et al.
Lei Fang et al.
Acrolein is a major component of cigarette smoke and cooking fumes. Previously, we reported that acrolein compromises chromatin assembly; however, underlying mechanisms have not been defined. Here, we report that acrolein reacts with lysine...
Mutation of the 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Substrate-Docking Site in the Developing Brain Causes Microcephaly with Abnormal Brain Morphogenesis Independently of Akt, Leading to Impaired Cognition and Disruptive Behaviors [0.03%]
皮层神经元中PDK1底物结合位点的突变通过Akt非依赖性机制导致脑形态发生异常和小头畸形，伴有认知和行为缺陷
Lluís Cordón-Barris,Sònia Pascual-Guiral,Shaobin Yang et al.
Lluís Cordón-Barris et al.
The phosphoinositide (PI) 3-kinase/Akt signaling pathway plays essential roles during neuronal development. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) coordinates the PI 3-kinase signals by activating 23 kinases of the AGC family,...
p97 Promotes a Conserved Mechanism of Helicase Unloading during DNA Cross-Link Repair [0.03%]
P97促进DNA交联修复过程中保守的解旋酶卸载机制
George Fullbright,Halley B Rycenga,Jordon D Gruber et al.
George Fullbright et al.
Interstrand cross-links (ICLs) are extremely toxic DNA lesions that create an impassable roadblock to DNA replication. When a replication fork collides with an ICL, it triggers a damage response that promotes multiple DNA processing events ...