Alexandra Mazharian,Yotis A Senis
Alexandra Mazharian
Platelets, or thrombocytes are anucleate cell fragments of megakaryocytes (MKs) that are highly reactive to sites of vascular injury and implicated in many pathologies. However, the molecular mechanisms regulating the number and activity of...
Transcriptomic Analysis Uncovers an Unfolded Protein Response in ADNP Syndrome [0.03%]
转录组分析揭示了ADNP综合征中的未折叠蛋白反应
Anna Bieluszewska,Phillip Wulfridge,Kuo-Chen Fang et al.
Anna Bieluszewska et al.
Chromatin regulators are frequently mutated in autism spectrum disorders, but in most cases how they cause disease is unclear. Mutations in the activity dependent neuroprotective protein (ADNP) causes ADNP syndrome, which is characterized b...
Kinase Inhibitor-Induced Cell-Type Specific Vacuole Formation in the Absence of Canonical ATG5-Dependent Autophagy Initiation Pathway [0.03%]
经典的大自噬起始途径独立的激酶抑制剂诱导细胞类型特异性空泡形成反应
Susan Jose,Himanshi Sharma,Janki Insan et al.
Susan Jose et al.
Pyridinyl-imidazole class p38 MAPKα/β (MAPK14/MAPK11) inhibitors including SB202190 have been shown to induce cell-type specific defective autophagy resulting in micron-scale vacuole formation, cell death, and tumor suppression. We had ea...
Loss of HNRNPK During Cell Senescence Linked to Reduced Production of CDC20 [0.03%]
细胞衰老过程中HNRNPK丢失与CDC20产生减少有关
Chang Hoon Shin,Martina Rossi,Krystyna Mazan-Mamczarz et al.
Chang Hoon Shin et al.
Cellular senescence is a complex biological response to sublethal damage. The RNA-binding protein HNRNPK was previously found to decrease prominently during senescence in human diploid fibroblasts. Here, analysis of the mechanisms leading t...
Mariana D Mandler,Sneha Kulkarni,Pedro J Batista
Mariana D Mandler
RNA modifications are highly conserved across all domains of life, suggesting an early emergence and a fundamental role in cellular processes. The modification 3-(3-amino-3-carboxypropyl)uridine (acp³U) is found in tRNAs of eukaryotes and ...
Umur Keles,Nisan Ece Kalem-Yapar,Hanna Hultén et al.
Umur Keles et al.
Complex metabolic diseases due to overnutrition such as obesity, type 2 diabetes, and fatty liver disease are a major burden on the healthcare system worldwide. Current research primarily focuses on disease endpoints and trying to understan...
The Role of Med15 Sequence Features in Transcription Factor Interactions [0.03%]
Med15序列特征在转录因子相互作用中的作用
David G Cooper,Shulin Liu,Emma Grunkemeyer et al.
David G Cooper et al.
Med15 is a general transcriptional regulator and tail module subunit within the RNA Pol II mediator complex. The Saccharomyces cerevisiae Med15 protein has a well-structured N-terminal KIX domain, three activator binding domains (ABDs) and ...
Anticancer Effect of C19-Position Substituted Geldanamycin Derivatives Targeting NRF2-NQO1-activated Esophageal Squamous Cell Carcinoma [0.03%]
NRF2-NQO1激活的食管鳞癌的C19位取代的 geldanamycin衍生物抗肿瘤作用
Hiroyuki Oshikiri,Keiko Taguchi,Wataru Hirose et al.
Hiroyuki Oshikiri et al.
In esophageal squamous cell carcinoma, genetic activation of NRF2 increases resistance to chemotherapy and radiotherapy, which results in a significantly worse prognosis for patients. Therefore NRF2-activated cancers create an urgent clinic...
Erythropoietin Production in Embryonic Neural Cells is Controlled by Hypoxia Signaling and Histone Deacetylases with an Undifferentiated Cellular State [0.03%]
红细胞生成素的产生受低氧信号和组蛋白去乙酰化酶以及未分化细胞状态的影响
Yuma Iwamura,Taku Nakai,Koichiro Kato et al.
Yuma Iwamura et al.
During mammalian development, production sites of the erythroid growth factor erythropoietin (EPO) shift from the neural tissues to the liver in embryos and to the kidneys in adults. Embryonic neural EPO-producing (NEP) cells, a subpopulati...