Targeting Ubiquitinated Protein Aggregates in Neurodegenerative Diseases: current Status and Future Directions [0.03%]
神经退行性疾病中靶向泛素化蛋白聚集体的现状和未来方向
Masahiko Takahashi,Takayuki Abe,Masahiro Fujii
Masahiko Takahashi
Various cellular stressors inhibit translation initiation and promote ribosome disassembly, thereby transiently inducing stress granules (SGs), dynamic ribonucleoprotein condensates that contain mRNAs and RNA-binding proteins. Although SG a...
Global Profiling of Remodeled Subcellular Structures Due to Drug Treatment and Disease [0.03%]
药物治疗和疾病引起的重塑的亚细胞结构的全局分析
Rachel A Victor,Jesse J Altemus,Michelle A Lay et al.
Rachel A Victor et al.
Cellular biochemistry arises from various interactions between macromolecules, including proteins, nucleic acids, and lipids. These make up membrane-bound organelles, membrane-less compartments, and molecular assemblies and scaffolds. Chang...
Frequent Functional Orthology of Characterized Long Noncoding RNAs and Genomic Loci Associated with Complex Traits and Disorders [0.03%]
已知长链非编码RNA和与复杂性状及疾病相关的基因组位点频繁具有功能同源性
Mitchell J Cummins,John S Mattick
Mitchell J Cummins
Genome wide association studies (GWAS) have identified many haplotype blocks linked to a wide range of complex human traits, including intelligence, neuropsychiatric disorders, and immunological disorders, among many others. Approximately a...
So Masaki,Takayuki Nojima,Takako Oshiro-Ideue et al.
So Masaki et al.
Pyruvate kinase M (PKM) catalyzes the conversion of phosphoenolpyruvate to pyruvate in glycolysis and exists as two splice isoforms, PKM1 and PKM2, generated from alternative splicing of mutually exclusive exons 9 or 10, respectively. The e...
The Emerging Role of mTOR in Shaping the Cancer Cell Secretome and Plasticity [0.03%]
mTOR在塑造癌细胞分泌组和可塑性中的作用不容忽视
Tyler T Cooper,Ivan Topisirovic,Lynne M Postovit
Tyler T Cooper
As tumors expand and encounter hypoxia and nutrient deprivation, cancer cells must establish tight coordination between metabolic reprogramming, protein synthesis and secretory activity to enable effective adaptation. The mechanistic target...
KLF11 in Extracellular Vesicles Derived from adMSCs Inhibits Colorectal Cancer via Suppressing SOAT1-Mediated Lipogenesis [0.03%]
来源于adMSCs的外泌体中的KLF11通过抑制SOAT1介导的脂质生成抑制结直肠癌
Fan Yang,Haitao Yu,Jian Ni et al.
Fan Yang et al.
Colorectal cancer (CRC) remains one of the most frequently diagnosed and lethal malignancies. Recent studies showed that either adipose-derived mesenchymal stem cells (adMSCs) or the extracellular vesicles (EVs) they secrete retarded CRC pr...
ZRANB1 and ACSS2 Cooperate to Regulate Ubiquitination and Acetylation to Stabilize TWIST1 in Breast Cancer Metastasis [0.03%]
ZRANB1和ACSS2协作调节泛素化和乙酰化以稳定乳腺癌转移中的TWIST1蛋白质
Yeqing Xu,Liufang Zhou,Dizheng Liao et al.
Yeqing Xu et al.
The epithelial-mesenchymal transition (EMT) transcription factor TWIST1 plays a critical role in breast cancer progression. This study reveals that TWIST1 acetylation, which is elevated in metastatic breast cancer tissues, is regulated by a...
Gasdermin D Inhibition Attenuates Mitochondrial Damage and Cardiomyocyte Pyroptosis in Heart Failure with Preserved Ejection Fraction [0.03%]
gasdermin D 抑制减轻射血分数保留心力衰竭的心肌细胞线粒体损伤和细胞焦亡
Linlin Chen,Zhiming Jiang,Cheng Li et al.
Linlin Chen et al.
Heart failure with preserved ejection fraction (HFpEF) represents the most prevalent subtype of heart failure globally, with its underlying pathogenesis remaining incompletely elucidated. Pyroptosis and mitochondrial dysfunction have been i...
Dual Sub‑MIC Copper-Gentamicin Stress Drives Strain‑Specific, Non‑Additive Phenotypic Shifts in Pseudomonas aeruginosa [0.03%]
双次 MIC 状态下铜离子和硫酸庆大霉素应激驱动的铜绿假单胞菌品系特异性、非累加的表型变化
Agata Dorotkiewicz-Jach,Patrycja Paszkowska,Barbara Maciejewska et al.
Agata Dorotkiewicz-Jach et al.
Exposure to redox‑active metals and sub‑inhibitory antibiotics represents a significant selective pressure shaping bacterial physiology and antimicrobial susceptibility. Here, we investigated how four genetically and phenotypically distin...
Lianna Fiore,Zhijie Li,Collin Montgomery et al.
Lianna Fiore et al.
Gene expression regulated through a set of transcription factors orchestrates the physiologic processes that drive mammary gland development, breast cancer oncogenesis, and breast cancer progression. This review highlights recent progress i...