The evolution of a Na+-sensitive Vibrio cholerae mutant unmasks the moonlighting aminopeptidase PepA as a regulator of nhaB Na+/H+ antiporter gene expression [0.03%]
钠敏感的霍乱弧菌突变体的进化揭露了多功能天冬氨肽酶PepA作为调控基因nhaB的表达的调节因子的功能
Sebastian Herdan,Katharina Kohm,Robert Warneke et al.
Sebastian Herdan et al.
The pathogenic bacterium Vibrio cholerae is aquatic and can be cultivated in nutrient media with increased salt concentration. To maintain osmotic balance, V. cholerae uses Na+/H+ antiporters and a Na+-translocating NADH:quinone oxidoreduct...
Identification of a conserved GNAT-family lysine acetyltransferase in Streptococcus gordonii involved in biofilm formation and oral colonization [0.03%]
识别出一组参与葛氏链球菌生物膜形成和口腔定植的保守GNAT家族赖氨酸乙酰化酶
Joseph O&#x;Brien,Flavia M Saavedra,Irene Choi et al.
Joseph O&#x;Brien et al.
Streptococcus gordonii is a gram-positive oral bacterium capable of adhering to a variety of biotic and abiotic surfaces and forming biofilms. To characterize physiological changes associated with biofilm formation in S. gordonii, we invest...
Oxygen-dependent partitioning of acetate assimilation via Acs and AckA-Pta pathways in Pseudomonas aeruginosa [0.03%]
铜绿假单胞菌中乙酸酯摄取的氧依赖性分区现象及其途径功能分析
M E Watkins,K V Tonapi,C M VanDrisse
M E Watkins
Pseudomonas aeruginosa is a metabolically versatile pathogen that thrives in host environments characterized by gradients of oxygen and nutrient availability. Although acetate is an abundant carbon source in chronic infections, the mechanis...
Hypermucoviscosity in Klebsiella pneumoniae: manifestation, regulation, and roles in pathogenesis [0.03%]
肺炎克雷伯菌高黏液表型的分子机制及其致病作用
Tamal Dey,Manoharan Shankar
Tamal Dey
In recent years, Klebsiella pneumoniae (Kpn) has evolved into a global public health threat. Convergent Kpn lineages that are both hypervirulent and multidrug-resistant have emerged and can cause community-acquired, drug-resistant infection...
A genome-wide screen in Pseudomonas aeruginosa identifies genes impacting production of the hemolytic phospholipase C/sphingomyelinase, PlcH [0.03%]
全基因组筛选鉴定出影响恶臭假单胞菌血红素磷脂酶C/鞘氨醇磷酸-diesterase（PlcH）产生的基因
Kristin Schutz,Olivia F Evans,Jacob R Mackinder et al.
Kristin Schutz et al.
The secreted phospholipase C/sphingomyelinase, PlcH, is the heat-labile hemolysin of Pseudomonas aeruginosa and one of its important secreted virulence factors. While there are known and suspected genes that impact PlcH production in P. aer...
Transcriptional landscape of metal-resistant Cupriavidus metallidurans: one sigma factor to rule them all [0.03%]
金属耐受型芽孢杆菌的转录图谱：一个σ因子统治他们所有
Dietrich H Nies,Jan Grau,Grit Schleuder et al.
Dietrich H Nies et al.
Cupriavidus metallidurans is able to grow in the presence of transition metal mixtures with high concentrations and varying compositions. This ability is mediated by a multitude of metal transport and repository systems. To reveal the genet...
Manju Narwal,Yeonoh Shin,Katsuhiko S Murakami
Manju Narwal
Coliphage N4 employs a unique infection and transcription strategy in which early gene expression is driven by a virion-encapsidated RNA polymerase (vRNAP) that is injected into the host cytoplasm upon infection. Despite extensive biochemic...
Mce transport systems in Mycobacterium tuberculosis: architecture, regulation, lipid import, and translational perspectives [0.03%]
结核分枝杆菌中的Mccest系统：结构、调控、脂质摄取与展望
Haishan Tan,Yuxiang Hu,Qinglan Wang
Haishan Tan
Mammalian cell entry (Mce) systems are now recognized as central determinants of lipid uptake, cell-envelope homeostasis, and host adaptation in Mycobacterium tuberculosis (Mtb). Although the term "mammalian cell entry" originated from earl...
Integrating multi-omics data with network modeling to characterize Pseudomonas aeruginosa persister cell metabolism [0.03%]
整合多组学数据与网络模型以表征恶臭假单胞菌休眠细胞代谢
Joseph M Ficarrotta,Anna S Blazier,Aline Metris et al.
Joseph M Ficarrotta et al.
Pseudomonas aeruginosa is a gram-negative bacterial pathogen capable of forming antimicrobial-tolerant subpopulations known as persister cells. These cells are transient phenotypic variants that can tolerate antimicrobial treatment and have...
Short-chain fatty acids activate the glutamate-dependent acid resistance system via the tRNA-modifying Mnm pathway in Escherichia coli [0.03%]
短链脂肪酸通过tRNA修饰的Mnm途径激活大肠杆菌中的谷氨酸依赖性酸抵抗力系统
Lingyun Guo,Sophie Brameyer,Nicola Victoria Hoesch et al.
Lingyun Guo et al.
Acid resistance is an important trait of enterobacteria, enabling survival under extreme gastric acidity (pH < 2.5) and the moderately acidic conditions in the large intestine (pH 5-6). In Escherichia coli, the glutamate-dependent acid resi...