Proteomic profiling reveals immunomodulatory role of IL-33 in ocular bacterial and fungal infections [0.03%]
蛋白组学分析揭示IL-33在眼部细菌和真菌感染中的免疫调节作用
Zeeshan Ahmad,Sukhvinder Singh,Dhanwini Rudraprasad et al.
Zeeshan Ahmad et al.
Bacterial and fungal pathogens are major causes of infectious endophthalmitis following eye surgery or trauma, often leading to vision impairment or blindness. The distinct clinical outcomes observed in bacterial and fungal endophthalmitis ...
Trimming the fat: a brief review of lipids at the host-pathogen interface [0.03%]
减脂增效：宿主与病原微生物互作中的脂质研究综述
Filiz T Korkmaz
Filiz T Korkmaz
Microbial-derived lipids and the host receptors that bind them are collectively critical for immune regulation on the host side and for a multitude of biological functions on the microbial side, including membrane structure, energy generati...
Bridget A Bowman,Fernanda O Novais
Bridget A Bowman
Oxygen availability plays a fundamental role in shaping immune responses to infections. Leishmaniasis, a disease caused by protozoan parasites of the genus Leishmania, manifests in a spectrum of clinical outcomes, ranging from localized cut...
Working together: gut microbe-microbe interactions shape host inflammation [0.03%]
携手并进-肠道微生物之间的相互作用影响宿主炎症反应
Ally Lawing,Rachel Bleich
Ally Lawing
Inflammatory bowel disease (IBD) is a debilitating disorder characterized by chronic intestinal inflammation that currently has no cure. Alterations to the composition of the gut microbiota, including reduced microbial diversity and expansi...
Monoclonal antibody neutralizes Staphylococcus aureus serine protease-like protein B (SplB)-induced pathology [0.03%]
单克隆抗体中和金黄色葡萄球菌丝氨酸蛋白酶样蛋白B(SplB)诱导的病理变化
Jawad Iqbal,Jessica von Fournier,Nico Wittmann et al.
Jawad Iqbal et al.
Staphylococcus aureus is a versatile pathogen, renowned for its arsenal of virulence and immune evasion factors. Several S. aureus virulence factors have been targeted in vaccination trials; however, so far, without success. Promising new v...
Investigating the immunomodulatory effects of honeybee venom peptide apamin in Drosophila platforms [0.03%]
利用果蝇模型研究蜜蜂毒液肽apamin的免疫调节作用
Yanan Wei,Wenjie Jia,Yanying Sun et al.
Yanan Wei et al.
Apamin, an 18-amino-acid honeybee venom peptide, although traditionally recognized for its neurotoxic effects, demonstrates potent antimicrobial properties in our research when genetically expressed in Drosophila. This antimicrobial efficac...
GM-CSF engages multiple signaling pathways to enhance pro-inflammatory cytokine responses in human monocytes during Legionella infection [0.03%]
GM-CSF通过多种信号通路增强Legionella感染期间人单核细胞的促炎细胞因子反应
Víctor R Vázquez Marrero,Madison Dresler,Mikel D Haggadone et al.
Víctor R Vázquez Marrero et al.
The proinflammatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) is required for host defense against a wide range of pathogens. During infection with the intracellular bacterial pathogen Legionella pneumophila, we pre...
Multi-system dysregulation in placental malaria contributes to adverse perinatal outcomes in mice [0.03%]
胎盘疟疾多系统紊乱会导致小鼠不良的围产期结局
Phebe Ekregbesi,Brittany Seibert,Maclaine A Parish et al.
Phebe Ekregbesi et al.
Sequestration of Plasmodium parasites in the placental vasculature contributes to increased morbidity and mortality in pregnant compared to non-pregnant patients in malaria-endemic regions. In this study, outbred pregnant CD1 mice with semi...
Characterization of the Listeria monocytogenes PieRS regulon distinguishes the function of the critical secretion chaperone PrsA2 from other regulon members [0.03%]
链球菌PieRS调控子的特征确定将关键性分泌分子伴侣PrsA2与其他调节成员的功能区分开来
Xiomarie Alejandro-Navarreto,Laty A Cahoon,Nancy E Freitag
Xiomarie Alejandro-Navarreto
Listeria monocytogenes (Lm) is a gram-positive pathogen that is widespread throughout the environment and known for its ability to infect mammalian hosts following the ingestion of contaminated food. Lm uses a variety of mechanisms to survi...
Ficolin-1 in pediatric Plasmodium falciparum malaria and its possible role in parasite clearance and anemia [0.03%]
儿童恶性疟原虫疟疾中的FcγⅠ和其在清除病原体和贫血中的可能作用
Di Zheng,Natalie Ferrington,Dilini Rathnayake et al.
Di Zheng et al.
Plasmodium falciparum malaria causes significant disease, especially in young children. A successful immune response to P. falciparum is a major determinant of clinical outcome. The ficolins are a family of lectins that act as pattern recog...