Investigating the immunomodulatory effects of honeybee venom peptide apamin in Drosophila platforms [0.03%]
利用果蝇模型研究蜜蜂毒液肽apamin的免疫调节作用
Yanan Wei,Wenjie Jia,Yanying Sun et al.
Yanan Wei et al.
Apamin, an 18-amino-acid honeybee venom peptide, although traditionally recognized for its neurotoxic effects, demonstrates potent antimicrobial properties in our research when genetically expressed in Drosophila. This antimicrobial efficac...
GM-CSF engages multiple signaling pathways to enhance pro-inflammatory cytokine responses in human monocytes during Legionella infection [0.03%]
GM-CSF通过多种信号通路增强Legionella感染期间人单核细胞的促炎细胞因子反应
Víctor R Vázquez Marrero,Madison Dresler,Mikel D Haggadone et al.
Víctor R Vázquez Marrero et al.
The proinflammatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) is required for host defense against a wide range of pathogens. During infection with the intracellular bacterial pathogen Legionella pneumophila, we pre...
Multi-system dysregulation in placental malaria contributes to adverse perinatal outcomes in mice [0.03%]
胎盘疟疾多系统紊乱会导致小鼠不良的围产期结局
Phebe Ekregbesi,Brittany Seibert,Maclaine A Parish et al.
Phebe Ekregbesi et al.
Sequestration of Plasmodium parasites in the placental vasculature contributes to increased morbidity and mortality in pregnant compared to non-pregnant patients in malaria-endemic regions. In this study, outbred pregnant CD1 mice with semi...
Characterization of the Listeria monocytogenes PieRS regulon distinguishes the function of the critical secretion chaperone PrsA2 from other regulon members [0.03%]
链球菌PieRS调控子的特征确定将关键性分泌分子伴侣PrsA2与其他调节成员的功能区分开来
Xiomarie Alejandro-Navarreto,Laty A Cahoon,Nancy E Freitag
Xiomarie Alejandro-Navarreto
Listeria monocytogenes (Lm) is a gram-positive pathogen that is widespread throughout the environment and known for its ability to infect mammalian hosts following the ingestion of contaminated food. Lm uses a variety of mechanisms to survi...
Ficolin-1 in pediatric Plasmodium falciparum malaria and its possible role in parasite clearance and anemia [0.03%]
儿童恶性疟原虫疟疾中的FcγⅠ和其在清除病原体和贫血中的可能作用
Di Zheng,Natalie Ferrington,Dilini Rathnayake et al.
Di Zheng et al.
Plasmodium falciparum malaria causes significant disease, especially in young children. A successful immune response to P. falciparum is a major determinant of clinical outcome. The ficolins are a family of lectins that act as pattern recog...
Differentiating Peromyscus leucopus bone marrow-derived macrophages for characterization of responses to Borrelia burgdorferi and lipopolysaccharide [0.03%]
利用脂多糖和伯氏疏螺旋体分化白足鼠骨髓来源的巨噬细胞以表征其反应类型
Christopher C Wells,Tanja Petnicki-Ocwieja,Shumin Tan et al.
Christopher C Wells et al.
Currently, most tools utilized in host-pathogen interaction studies depend on the use of human or mouse (Mus musculus) cells and tissues. While these species have led to countless breakthroughs in our understanding of infectious disease, th...
Augmented insights and minor adjustments to the role of adhesin proteins in Acinetobacter baumannii infections [0.03%]
关于粘附素蛋白在鲍曼不动杆菌感染中作用的见解和微调
Dongmei Xiao,Huaichang Zhong,Qionghua Huang et al.
Dongmei Xiao et al.
Infectivity of a pathogenicity-attenuated Chlamydia muridarum mutant in the genital tract [0.03%]
减毒肺炎衣原体突变株的生殖道感染性研究
Caiting Li,Zhaoyang Liu,Yaoqin Hua et al.
Caiting Li et al.
A Chlamydia muridarum mutant designated as intrOv was evaluated as an intracellular oral vaccine vector because it can induce protection in the genital tract following oral inoculation but does not elicit genital pathology following intrava...
Acquisition of daptomycin resistance in patients results in decreased virulence in Drosophila [0.03%]
患者达托霉素耐药菌的获得减少了果蝇中的毒力
Brigitte Lamy,Frédéric Laurent,Carolina J Simoes Da Silva et al.
Brigitte Lamy et al.
Staphylococcus aureus can acquire antimicrobial resistance, which in turn may affect its pathogenic potential. Using a panel of paired clinical isolates collected before and after daptomycin resistance acquisition, most frequently through a...
Maternal transfer of oral vaccine induced anti-OspA antibodies protects Peromyscus spp. from tick-transmitted Borrelia burgdorferi [0.03%]
母体转移口服疫苗诱导的抗OspA抗体可保护鼠类免受由蜱传播的伯氏疏螺旋体感染
Jose F Azevedo,Greg Joyner,Suman Kundu et al.
Jose F Azevedo et al.
The efficacy and duration of passive immunity protection depend on maternal antibody levels and transfer efficiency. We investigated whether oral vaccination of Peromyscus leucopus dams with recombinant outer surface protein A (OspA)-expres...