T6SS1 suppresses pro-inflammatory cytokine transcription to drive immune evasion and systemic infection in Vibrio parahaemolyticus [0.03%]
天性毒素系统1通过抑制促炎细胞因子转录促进创伤弧菌免疫逃逸和全身感染
Shuqi Lu,Shuo Yuan,Pengxuan Liu et al.
Shuqi Lu et al.
The type VI secretion system (T6SS) is a major virulence factor in Vibrio parahaemolyticus, but its pathogenic mechanisms are poorly understood or still not fully understood. This study investigates how two critical T6SS1 structural compone...
Quorum-sensing regulator LsrR modulates avian pathogenic Escherichia coli pathogenicity through direct regulation of cysN [0.03%]
泛素感知调节因子LsrR通过直接调控cysN调节致病性禽源大肠杆菌的毒力
Saqib Nawaz,Zhihao Wang,Wei Jiang et al.
Saqib Nawaz et al.
Avian Pathogenic Escherichia coli (APEC) is a major cause of economic loss in poultry, exacerbated by the rising prevalence of antibiotic resistance. While sulfur metabolism is essential for bacterial growth, its specific role and regulatio...
Mannoprotein Cig1 contributes to the immunogenicity of a heat-killed F-box protein Fbp1 Cryptococcus neoformans vaccine model [0.03%]
卡宾蛋白Cig1参与F-box蛋白FBP1热灭活型新生隐球菌疫苗模型免疫原性研究
Samantha L Avina,Siddhi Pawar,Roshni N Kadam et al.
Samantha L Avina et al.
Currently, no fungal vaccine exists for clinical use, while fungal infections are responsible for over 1.5 million deaths every year. Our previous studies identified a Cryptococcus neoformans mutant strain fbp1Δ as a potential vaccine cand...
A retrospectively registered pilot randomized controlled trial of postbiotic administration during antibiotic treatment increases microbiome diversity and enriches health-associated taxa [0.03%]
一项回顾性注册的抗生素治疗期间补充后生元对增加微生物组多样性和丰富有益菌株作用的试点随机对照试验
Jonas Schluter,William Jogia,Fanny Matheis et al.
Jonas Schluter et al.
Antibiotic-induced microbiome injury, defined as a reduction of ecological diversity and obligate anaerobe taxa, is associated with negative health outcomes in hospitalized patients, and healthy individuals who received antibiotics in the p...
Immunogenicity and plasmid delivery pathways of non-invasive Lactococcus lactis-vectored mucosal DNA vaccination [0.03%]
植物乳桿菌介導的粘膜DNA疫苗免疫原性及其質粒輸送途徑研究
Sarana Kawashima,Keita Takahashi,Daiki Yanagisawa et al.
Sarana Kawashima et al.
Mucosal DNA vaccination using a non-invasive Lactococcus lactis (LL) vector has been investigated. However, its immunogenicity and plasmid transfer mechanisms remain largely unknown. In this study, we investigated the intranasal delivery of...
Differential virulence and immune recognition of Klebsiella pneumoniae O-antigen subtypes O2α and O2β [0.03%]
肺炎克雷伯氏菌O抗原型O2α和O2β的毒力差异及免疫识别能力不同
Paeton L Wantuch,Lloyd S Robinson,Cory J Knoot et al.
Paeton L Wantuch et al.
Klebsiella pneumoniae infections are sharply on the rise among at-risk populations. K. pneumoniae has nine serogroups of O-antigens. Recently, additional O-antigen subtypes within these serogroups have been identified; the contributions of ...
Comparison of cytokine responses to group B Streptococcus infection in a human maternal-fetal interface organ-on-a-chip system and ex vivo culture model of human gestational membranes [0.03%]
一种基于人体胎盘 fetal-maternal 交互器官芯片系统的b群链球菌感染细胞因子应答与人妊娠蜕膜组织切片的 ex vivo 文化模型比较研究
Leslie A Kirk,Hannah A Richards,Danyvid Olivares-Villagómez et al.
Leslie A Kirk et al.
Adverse pregnancy outcomes represent a global health burden. Bacterial infection and subsequent inflammation in gestational membranes lead to immunological and physiological changes that contribute to adverse pregnancy outcomes. Although an...
Antimicrobial resistance is widespread among intestinal and extra-intestinal Bacteroides fragilis strains [0.03%]
肠内和肠外拟杆菌对多种抗菌素具有耐药性
Marvic Carrillo Terrazas,Renee E Oles,Luke R Loomis et al.
Marvic Carrillo Terrazas et al.
Bacteroides fragilis is an important member of the human gut microbiota, where it contributes to immune modulation, intestinal barrier integrity, and colonization resistance. Despite its beneficial roles as a symbiont in the gut, B. fragili...
A zinc-free alternative ribosomal protein RpsN.2 confers survival advantage to group A streptococcus during Zn scarcity [0.03%]
无锌依赖的核糖体蛋白RpsN.2可使链球菌在缺锌条件下更易生存
Subhasree Saha,Aswin Thacharodi,Dieu Linh Nguyen et al.
Subhasree Saha et al.
Infection induces unfavorable environments in the host that can be detrimental to the survival of commensal and pathogenic bacteria. Although the adaptive strategies employed by pathogenic bacteria to overcome harsh environments are charact...
Generation of a toxin/antitoxin-based counterselection marker for Chlamydia trachomatis [0.03%]
利用毒素/抗毒素体系生成沙眼衣原体反向筛选标记物
Eleanor Steiner,Samantha D&#x;Spain,Rachel Ende et al.
Eleanor Steiner et al.
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infection in the United States. The high rate of asymptomatic cases and absence of a vaccine often leave infections untreated, increasing the risk of serious compl...