Diabetes and hyperglucosuria exacerbate the severity of urinary tract infection caused by uropathogenic E. coli in the mouse model [0.03%]
Sarita Neupane,Iris George,Veerakit Vanitshavit et al.
Sarita Neupane et al.
Diabetes and urinary tract infection (UTI) are major global public health problems. We investigated the effects of glucose on bacterial colonization and host response to UTI caused by uropathogenic Escherichia coli (UPEC) in a mouse model o...
Bacterial and host factors affecting acquisition of Streptococcus pneumoniae in a murine model [0.03%]
Daniel P Fecko,Cindy Wu,Jeffrey N Weiser
Daniel P Fecko
Initial acquisition is a critical step in the establishment of colonization that in turn enables transmission to new hosts and potentially leads to invasive disease. Here, we studied host and bacterial factors affecting acquisition, as dist...
Navin Jeyabalan,Frederick Reinhart Tanoto,Haris Antypas et al.
Navin Jeyabalan et al.
Chronic wound infections are a common comorbidity of diabetes mellitus and can progress to amputation if untreated, yet effective strategies to manage these infections are limited. Commensals such as Enterococcus faecium and Staphylococcus ...
SeaB is a conserved Salmonella enterica extracellular matrix binding protein involved in biofilm formation and infection [0.03%]
Rochelle M Da Costa,Jessica L Rooke,Faye C Morris et al.
Rochelle M Da Costa et al.
Salmonella enterica is a leading cause of gastroenteritis worldwide. Exacerbating this issue is the emergence of multi-drug-resistant strains, posing a major threat to human health. Type 5 secretion system proteins play a major role in viru...
Michelle J Vaz,Sanjana Sankaran,Molly E Sharp et al.
Michelle J Vaz et al.
Group B Streptococcus (GBS) intestinal colonization is critical for the pathogenesis of late-onset disease in infants. Using a murine model, we explore the role of rodA, which encodes a peptidoglycan polymerase RodA, belonging to the shape,...
Mesenchymal stem cell-derived conditioned medium demonstrates novel antibacterial effects in ocular bacterial infections [0.03%]
Sairam Abbireddy,Joveeta Joseph,Bhupesh Bagga et al.
Sairam Abbireddy et al.
Bacterial keratitis is a potentially blinding corneal infection, with Staphylococcus aureus and Pseudomonas aeruginosa being the leading gram-positive and gram-negative pathogens, respectively. The increasing antimicrobial resistance among ...
CCR6 is essential for effective immunity against Mycobacterium tuberculosis infection in mice [0.03%]
Summer J Harris,Oyindamola O Adefisayo,Rachel K Meade et al.
Summer J Harris et al.
Tuberculosis (TB) is a global epidemic that has threatened human health throughout recorded history. TB disease, caused by infection with Mycobacterium tuberculosis (M.tb), is heterogeneous between individuals, and clinical TB outcomes are ...
Immunological mechanism behind reactivated cryptococcosis in persistently infected mice following FTY720 treatment [0.03%]
Michiko Yoshida,Ko Sato,Nana Nakahata et al.
Michiko Yoshida et al.
The Cryptococcus neoformans species complex (CNSC), responsible for cryptococcosis, is controlled by Th1-type immunity, in which IFN-γ-activated macrophages form granulomas that contain infection. Nevertheless, CNSC can evade host immunity...
Lysosomal permeabilization by Group A Streptococcus releases proteins into the macrophage cytosol [0.03%]
Ava Quezada,Kevin Lord,Cheldon Alcantara et al.
Ava Quezada et al.
The human-specific bacterial pathogen Group A Streptococcus (GAS) is a significant cause of morbidity and mortality due to its ability to cause severe invasive infection. Although macrophages are important for controlling GAS infection, we ...
Xuemei Wang,Cuixiu Wu,Yidan Gao et al.
Xuemei Wang et al.
The cGAS-STING pathway is activated during chlamydial infection and plays a critical role in controlling Chlamydia trachomatis infection in the mouse lower genital tract. The current study evaluated whether intravaginal administration of ex...