Characterization of an isogenic bimA mutant in the ATS2021 strain of Burkholderia pseudomallei [0.03%]
Burkholderia pseudomallei 菌株ATS2021的同基因bimA突变体的表征
Christopher K Cote,Sherry Mou,Michael L Davies et al.
Christopher K Cote et al.
Encephalomyelitis is uncommon but is associated with Burkholderia pseudomallei strains whose bimA gene, encoding an actin-based motility protein, resembles bimA from Burkholderia mallei (designated bimABm). We previously characterized the v...
HnRNPA2B1 tunes antimycobacterial immune responses in macrophages through alternative splicing of Irgm1 [0.03%]
hnRNPA2B1通过Irgm1的可变剪接调节巨噬细胞中的抗结核免疫反应
M J Chapman,J B Huskey,K S Armijo et al.
M J Chapman et al.
The onset and progression of active tuberculosis disease result from upsetting the delicate balance between Mtb virulence and host defenses. Because it dynamically tunes the functional output of protein expression in cells, alternative spli...
Vaginal microbiome composition in pregnant and non-pregnant women: community structure, population variation, clinical impact, and metagenomics approaches [0.03%]
孕妇和非孕妇的阴道微生物组：群落结构、群体变化、临床影响及元基因组方法
Daiki Jonouchi,Srusti Shenoy,Renise Saintlouis et al.
Daiki Jonouchi et al.
The vaginal microbiome plays a critical role in reproductive health and undergoes characteristic remodeling during pregnancy that influences maternal and neonatal outcomes. Although the non-pregnant vaginal microbiome shows substantial inte...
Differential activation of NF-Κβ and HIF-1α between fetal liver-derived and myeloid-derived macrophages drives inflammatory differences following Mycobacterium abscessus infection [0.03%]
胎儿肝衍生和髓样衍生的巨噬细胞在感染Myobacterium abscessus后的NF-κβ和HIF-1α活化差异驱动炎症反应的不同
Haleigh N Gilliland,Soledad Soverina,Kayla N Conner et al.
Haleigh N Gilliland et al.
Pulmonary infections caused by Mycobacterium abscessus (Mab), a rapidly growing nontuberculous mycobacterium (NTM), are rising in patients with preexisting lung disease. Unfortunately, the natural recalcitrance of Mab to antibiotics drives ...
Fetal and neonatal demise in zoonotic diseases: pathology and pathogenesis [0.03%]
人畜共患病中的胎儿及新生儿死亡：病理与发病机制
Laice Alves da Silva,Thaynara Parente de Carvalho,Monique Ferreira Silva Souza et al.
Laice Alves da Silva et al.
Zoonotic infections constitute a major cause of reproductive failure and perinatal mortality in humans and animals. Among the most relevant etiological agents are Listeria monocytogenes, Brucella spp., and Toxoplasma gondii, which, despite ...
Liliana S McKay,Andrew Camilli,Peggy A Cotter
Liliana S McKay
Bacterial physiology plays an important role in virulence. Being a pathogen is energetically expensive, requiring the production of specialized virulence factors and other proteins that enable survival within the host. The most efficient wa...
Salmonella Typhi asparaginase-dependent activation of GCN2 promotes bacterial killing in murine macrophages [0.03%]
沙门氏菌酪酸亚硝基酶依赖性激活GCN2促进小鼠巨噬细胞中的细菌杀灭作用
Zachary M Powers,Michael J McFadden,Gi Young Lee et al.
Zachary M Powers et al.
Many intracellular pathogens stimulate host cell stress by directly or indirectly causing an imbalance in host nutrients. Depletion of amino acid pools, in particular, can act as a danger signal to infected cells. Using a restrictive host m...
Analysis of in vivo infection dynamics using bioluminescent Giardia duodenalis [0.03%]
利用生物发光性Giardia duodenalis分析感染的动态过程
Rita Kosile,Bergeline C Nguemwo Tentokam,Peiran Shen et al.
Rita Kosile et al.
Giardia duodenalis is an intestinal protozoan transmitted through contaminated food and water and is a major cause of diarrheal disease worldwide and has been linked to post-infectious sequelae and growth impairment in children. Quantifying...
Individual contributions of exotoxins S and T on internalized P. aeruginosa [0.03%]
绿脓杆菌毒素S和T对细胞内菌落形成的影响及机制研究
Zachary J Resko,Adam V Thota,Christopher J Corcoran et al.
Zachary J Resko et al.
Pseudomonas aeruginosa is a high-priority pathogen and significant burden to health care worldwide. Although often regarded as an extracellular pathogen, P. aeruginosa is also capable of existing intracellularly in multiple cell types, incl...
The diabetic wound microenvironment drives emergence and maintenance of CovRS variants in group B Streptococcus [0.03%]
糖尿病伤口微环境驱动B群链球菌CovRS变体的产生与维持
Rebecca A Keogh,Alyx M Job,Luke R Joyce et al.
Rebecca A Keogh et al.
Diabetic wounds are often infected with microbes, which perpetuate inflammation, and stall wound healing. The bacterium Group B Streptococcus (GBS) is frequently isolated from diabetic wounds; however, little is known about how GBS adapts t...