Determinants of susceptibility and tolerance of Streptococcus pneumoniae to hypothiocyanous acid [0.03%]
Balázs Rada,Jorge E Vidal
Balázs Rada
Infections caused by Streptococcus pneumoniae (Spn, pneumococcus), manifesting as pneumonia, meningitis, and otitis media, represent a leading cause of severe morbidity and mortality globally. Escalating antibiotic resistance and serotype r...
The growth and pathogenesis of Citrobacter rodentium are compromised when multiple mucin sugar utilization pathways are disrupted, leading to accumulation of N-acetylglucosamine 6-phosphate [0.03%]
Zhiquan Clarence Huang,Matthias Ahmad Mslati,Caixia Ma et al.
Zhiquan Clarence Huang et al.
Many enteric bacterial pathogens, including attaching/effacing (A/E) Escherichia coli strains, cause acute gastroenteritis in humans. Considering the highly competitive nature of the mammalian gastrointestinal (GI) tract, these pathogens mu...
Mono- and co-infections of primary porcine respiratory cells with Bordetella bronchiseptica and Streptococcus suis are not affected by the dermonecrotic toxin [0.03%]
猪源原发呼吸道上皮细胞同时或单独感染副猪嗜血杆菌和溶血性链球菌时，皮肤坏死毒素没有影响
Désirée Schaaf,Muriel Dresen,Yenehiwot Berhanu Weldearegay et al.
Désirée Schaaf et al.
Bordetella bronchiseptica is a gram-negative bacterium contributing to respiratory diseases in many different animal species. In the swine population, it occurs frequently and plays a role in the Porcine Respiratory Disease Complex as well ...
Enhanced Salmonella mortality in naturally resistant, immunocompetent male mice is associated with an altered systemic immune response [0.03%]
自然抵抗且免疫功能完好的小鼠中沙门氏菌导致的死亡率升高与系统性免疫反应改变有关
Aliyah N Bennett,Allysa L Cole,John S Gunn
Aliyah N Bennett
While typhoid fever affects both sexes at an equal rate, males are at a higher risk for intestinal perforation, which increases mortality. The mechanisms behind the increased morbidity of typhoid fever in human males remain an important but...
The Borreliella burgdorferi BosR-associated small non-coding RNA BasA regulates virulence [0.03%]
波氏伯氏疏螺旋体BosR相关的小分子非编码RNA BasA调控毒力
Brittany L Shapiro,Prashant Jaiswal,Lisa J Funkhouser-Jones et al.
Brittany L Shapiro et al.
Post-transcriptional regulation is an adaptive response used by living systems to alter protein levels independently of transcription initiation. In bacteria, one mechanism of post-transcriptional regulation involves the binding of small, n...
DRP1/DMNL-1-mediated mitochondrial fission augments Rickettsia parkeri replication in macrophages [0.03%]
线粒体分裂通过增强Rickettsia parkeri在巨噬细胞中的复制而促进DRP1/DMNL-1介导的寄生虫生长
Elliott Collins,Natasha Kelly,Heather Green et al.
Elliott Collins et al.
Pathogenic Spotted Fever Group (SFG) Rickettsia species, including Rickettsia parkeri, replicate in endothelial cells and macrophages in vitro and during infections in murine models of disease. We demonstrated that infection of human macrop...
Defining the human lung pathodegradome of the V8 protease from Staphylococcus aureus [0.03%]
金黄色葡萄球菌V8蛋白酶的人类肺病理降解组学定义
Emilee M Mustor,Dale Chaput,Sophie Sipprell et al.
Emilee M Mustor et al.
Staphylococcus aureus is a globally relevant human pathogen and key driver of human morbidity and mortality. During infection, it employs a suite of extracellular proteases to subvert host defenses and promote disease progression. Key among...
Molecular and mechanistic insights into the gut-liver axis in K. pneumoniae infections: current advances and future directions [0.03%]
Klebsiella肺炎感染中肠道-肝脏轴的分子及机制研究：进展与展望
Jie Deng,Ling Cheng,Jinbo Liu et al.
Jie Deng et al.
Klebsiella pneumoniae is an opportunistic Gram-negative pathogen in clinical settings, primarily causing opportunistic infections in hospitals. The prevalence of liver abscess cases caused by hypervirulent K. pneumoniae (hvKP) has significa...
Maternal influences on oral microbiome development and implications for early childhood health: a systematic review [0.03%]
母亲对口腔微生物群发育的影响及其对孩子早期健康的意义：系统性综述
Audrey Wang,Lien Quynh Dao,Francisco Ramos-Gomez et al.
Audrey Wang et al.
A deeper understanding of how maternal-infant interactions shape the establishment and diversification of the oral microbiome could have significant clinical applications; however, relatively few studies emphasize early maternal-infant micr...
A Hidden "Promoter": Schistosoma japonicum soluble egg antigen activates MAPK/PI3K-AKT pathways and inhibits autophagy to facilitate colorectal cancer [0.03%]
隐匿的“促癌者”：日本血吸虫卵抗原通过激活MAPK/PI3K-AKT信号通路和抑制自噬促进结直肠癌发生发展
Jinyuan Zhang,Wenwen Zheng,Yiyan Gong et al.
Jinyuan Zhang et al.
Schistosomiasis affects approximately 250 million people globally. Eggs deposited in the colon are the main culprits causing pathological damage, with soluble egg antigen (SEA) being the most significant pathogenic factor in schistosomiasis...