Growing Staphylococcus aureus in synthetic cystic fibrosis medium promotes colonization in a murine pneumonia model [0.03%]
在合成囊性纤维化培养基中培养金黄色葡萄球菌可促进肺炎小鼠模型定植
Justin M Luu,Ian N Moore,Dina A Moustafa et al.
Justin M Luu et al.
Staphylococcus aureus is a leading cause of bacterial infections worldwide and can lead to diseases, such as osteomyelitis, skin, and lung infections in humans. Murine infection models have been an essential tool to the study of S. aureus v...
Early enhanced control of Plasmodium yoelii infection in IL-10-deficient mice is independent of IFN-γ, IL-12, and the humoral response [0.03%]
白细胞介素(IL)-10缺陷型小鼠疟原虫(Plasmodium yoelii)感染的早期强化控制与干扰素(ifn)-γ、il-12和体液反应无关
Meghan D Jones,Kara A O&#x;Neal,Sheldon L Zeltner et al.
Meghan D Jones et al.
The outcome of a Plasmodium infection depends on the timely regulation of the robust pro-inflammatory response required to eliminate the parasite, but this response can cause tissue damage if not properly controlled. Interleukin-10 (IL-10) ...
Characterization of Pasteurella multocida type B capsule biosynthesis proteins [0.03%]
多杀巴斯德菌B型荚膜合成蛋白的表征
Thomas R Smallman,Chantelle M Cairns,Frank St Michael et al.
Thomas R Smallman et al.
Pasteurella multocida causes several severe animal diseases, including hemorrhagic septicemia in ungulates. Strains of P. multocida are differentiated into five capsular and nine lipopolysaccharide genotypes. To date, only P. multocida stra...
Dual roles of genes required for intrinsic resistance to clarithromycin in evasion of killing by serum complement in Haemophilus influenzae [0.03%]
白喉荚膜杆菌对克拉霉素固有耐药相关基因在逃避血清补体杀伤中的双刃剑效应
Cameron Huhn,Justine Dees,Jeffrey Gawronski et al.
Cameron Huhn et al.
Macrolide antibiotics are commonly prescribed to treat Haemophilus influenzae respiratory tract infections. Studies have primarily focused on emerging H. influenzae strains with acquired macrolide resistance, while the bacterium's intrinsic...
Subunits of adaptor protein complex-1 make distinct contributions to the virulence of Cryptococcus neoformans [0.03%]
适应蛋白复合物-1的亚基在新型隐球菌毒力中的不同作用
Kabir Bhalla,Eddy Sánchez-León,Yu-Hsuan Huang et al.
Kabir Bhalla et al.
Cryptococcal meningoencephalitis is among the most prevalent invasive fungal diseases, posing a threat to immunocompromised individuals and representing a growing global health concern. The mechanisms of cryptococcal trafficking of virulenc...
A multivalent subunit vaccine augments pre-existing immunity to protect against T3SS-positive Pseudomonas aeruginosa but reveals immunological interference against ExlA-positive strains [0.03%]
一种多价亚单位疫苗可增强对产T3SS的潘氏杆菌的先天免疫保护，但会对ExlA阳性菌株产生免疫干扰
Debaki R Howlader,Sayan Das,Satabdi Biswas et al.
Debaki R Howlader et al.
Pseudomonas aeruginosa (Pa) is a ubiquitous, opportunistic nosocomial pathogen that poses a significant threat due to its innate and acquired multidrug resistance. Novel vaccine strategies are urgently needed for vulnerable populations, man...
The AP-1 adaptor complex is required for cell surface modifications and the survival of Cryptococcus neoformans in phagocytic cells [0.03%]
AP-1衔接子复合物是新生隐球菌在吞噬细胞中存活所必需的
Eddy Sánchez-León,Kabir Bhalla,Victoria French et al.
Eddy Sánchez-León et al.
The pathogenic yeast Cryptococcus neoformans causes life-threatening meningoencephalitis in individuals with compromised immune systems. The ability of the fungus to cause disease depends on key cell-surface features, such as a polysacchari...
Desiccation tolerance as a driver of environmental persistence and transmission in nosocomial bacterial pathogens [0.03%]
干燥容忍性作为医院细菌病原体环境持久性和传播的驱动因素
Michael J Bucher,Alejandro Rivera-Madera,Erin R Green
Michael J Bucher
Hospital-acquired infections (HAIs) represent a major global health burden, leading to increased patient morbidity, mortality, and healthcare costs. These infections frequently occur following patient contact with microbial pathogens persis...
Innate immune recognition of Debaryomyces hansenii requires Dectin-1-Card9 signaling [0.03%]
Dectin-1-Card9信号通路介导的德巴利酵母 innate免疫识别
Kevin P Newhall,Sarah K McNeer,Scott T Espenschied et al.
Kevin P Newhall et al.
Innate immune signaling plays a key role in host response to infection, yet the pattern recognition receptors that detect non-model gut-associated yeasts remain poorly defined. Here, we investigated macrophage sensing of Debaryomyces hansen...
Curiouser and curiouser: understanding the intersection of inter- and intra-specific diversity during the Borrelia burgdorferi enzootic cycle and Lyme disease [0.03%]
越来越奇怪：在莱姆病的螺旋体杆菌流行周期中的种间和种内多样性相互作用的理解
Marina S Winter,Kareem D Adams,Jeffrey S Bourgeois
Marina S Winter
A consequence of the Borrelia (Borreliella) burgdorferi lifecycle is that a "standard" host-pathogen interaction involving the spirochete is challenging to define. The bacteria continuously cycle between vertebrate and invertebrate hosts, e...