CRISPR-based genetic tools for the study of host-microbe interactions [0.03%]
基于CRISPR的遗传工具研究宿主微生物相互作用
Martin Echavarria Galindo,Yong Lai
Martin Echavarria Galindo
CRISPR-based genetic tools have revolutionized our ability to interrogate and manipulate genes. These tools can be applied to both host and microbial cells, and their use can enhance our understanding of the dynamic nature of host-microbe i...
Cross-species protection suggests Entamoeba histolytica trogocytosis enables complement resistance through the transfer of negative regulators of complement activation [0.03%]
跨物种保护表明溶组织内阿米巴细胞吞噬作用通过转移补体调节蛋白使阿米巴逃避宿主补体的攻击
Maura C Ruyechan,Wesley Huang,Katherine S Ralston
Maura C Ruyechan
Entamoeba histolytica is a major cause of diarrheal disease. E. histolytica trophozoites ("amoebae") can invade the intestine and disseminate via the bloodstream, resisting complement lysis through unknown mechanisms. Amoebae kill human cel...
Structural and functional characterization of IdeC, a novel IgG-specific protease of Streptococcus canis [0.03%]
新型金黄色葡萄球菌IgG特异性蛋白酶IdeC的结构与功能研究
Saoirse Walsh,Antje-Maria Lapschies,Vega Miguel-Ruano et al.
Saoirse Walsh et al.
Streptococcus canis is an important opportunistic pathogen of cats, dogs, and cows, which can cause a range of infections, ranging from skin and soft tissue infections to septicemia and endocarditis. As a zoonotic agent, S. canis has also r...
Tick-borne coinfections modulate CD8+ T cell response and progressive leishmaniosis [0.03%]
蜱传共感染调节CD8+t细胞反应和利什曼病的进展
Breanna M Scorza,Danielle Pessôa-Pereira,Felix Pabon-Rodriguez et al.
Breanna M Scorza et al.
Leishmania infantum causes human visceral leishmaniasis and leishmaniosis (CanL) in reservoir host, dogs. As infection progresses to disease in both humans and dogs, there is a shift from controlling type 1 immunity to a regulatory, exhaust...
Edwardsiella ictaluri type III secretion system effector EseG modulates cytoskeletal dynamics and immune response in macrophages [0.03%]
爱德华氏菌属伊ctaluri亚种III型分泌系统效应物EseG调节巨噬细胞的细胞骨架动力学和免疫反应
Lidiya Dubytska,Ranjan Koirala,Matthew Rogge et al.
Lidiya Dubytska et al.
Edwardsiella ictaluri is a gram-negative enteric pathogen responsible for enteric septicemia of catfish. One of the critical virulence factors identified in E. ictaluri is its type III secretion system (T3SS). In this study, we report that ...
Saloni Bhimani,Mariola J Ferraro
Saloni Bhimani
Alfred R Babich
Alfred R Babich
Surface antigen SAG1 mediates Toxoplasma gondii fitness and host cell attachment in IFNγ-stimulated cells [0.03%]
表面抗原SAG1介导刚地列尅贾第虫在干扰素-γ刺激细胞中的适应性和宿主细胞黏附作用
Olivia Cohen,Parag Maru,Qinli Liang et al.
Olivia Cohen et al.
Toxoplasma gondii is an obligate intracellular protozoan parasite that can establish lifelong infections and cause severe disease in immunocompromised individuals. Interferon gamma (IFNγ) is a key host defense cytokine that induces a varie...
Brooke E Ryan,Laura A Mike
Brooke E Ryan
Nutrient availability shapes the course of infection. Arginine, a conditionally essential amino acid, plays a crucial role in both host immune defense and pathogen metabolism. As a precursor for nitric oxide production, arginine supports im...
Rickettsia heilongjiangensis suppresses RIPK1 kinase-mediated host cell death during the infection [0.03%]
洪湖立克次氏体感染期间该细菌能够抑制宿主细胞的坏死性凋亡
Maozhang He,Qingyin Shi,Yu Xin et al.
Maozhang He et al.
Spotted fever group Rickettsia (SFGR) poses a significant challenge in the field of tick-borne diseases, characterized by its obligate intracellular lifestyle and its ability to disrupt various host cellular pathways. A deeper understanding...