Myeloid cell-specific type I interferon signaling mediates age-dependent inflammation and protection in Bordetella pertussis infection [0.03%]
髓系细胞特异性Ⅰ型干扰素信号介导百日咳鲍特氏菌感染中的年龄依赖性炎症和保护作用
Amit Kumar,Alicia Bukowski,Nicholas H Carbonetti
Amit Kumar
Type I interferons (IFNs) play complex roles during bacterial infections. We previously found that type I IFNs were induced in Bordetella pertussis-infected adult mice but not in infant mice, a potentially relevant clinical dichotomy, since...
Inhibition of RND-mediated efflux attenuates antibiotic resistance and virulence in hypervirulent Klebsiella pneumoniae [0.03%]
抑制RND介导的外排可减轻高毒力肺炎克雷伯菌的抗生素耐药性和毒力
Mia E Van Allen,Yuding Weng,X Renee Bina et al.
Mia E Van Allen et al.
Klebsiella pneumoniae (Kp) is a major human pathogen causing hospital-acquired and community-acquired infections with emerging hypervirulent strains (hvKp) posing a significant threat due to its ability to cause severe invasive infections i...
Elevated glucose increases Staphylococcus aureus antibiotic resistance in a cystic fibrosis airway epithelial cell infection model [0.03%]
高糖可增加表皮气道细胞感染模型中金黄色葡萄球菌的耐药性
Emily M Hughes,Meghan J Hirsch,Joshua T Huffines et al.
Emily M Hughes et al.
In a healthy lung, the airway epithelium regulates glucose transport to maintain low glucose concentrations in the airway surface liquid (ASL). However, hyperglycemia and chronic lung diseases, such as cystic fibrosis (CF), can result in in...
Activation of the Pseudomonas aeruginosa glycerol regulon reduces antibiotic susceptibility and modulates virulence phenotypes [0.03%]
铜绿假单胞菌甘油调节子的激活可降低抗生素敏感性并改变毒力表型
Nicholas Evans,Tanaiyah Wilson,Jessica A Scoffield
Nicholas Evans
Chronic infections with Pseudomonas aeruginosa are a major contributor of lung decline in persons with cystic fibrosis (pwCF). P. aeruginosa establishes life-long infections in the CF airway by utilizing various adaptation strategies to per...
Complete deletion of the Chlamydia muridarum putative cytotoxin locus reveals contributions during invasion in tissue culture and oviduct pathology during murine genital tract infection [0.03%]
鼠沙眼衣原体毒基因位点完全缺失揭示了其在细胞培养和小鼠生殖道感染中的作用
Lucie H Berclaz,Gracie Eicher,Grace Wieselquist et al.
Lucie H Berclaz et al.
Chlamydiaceae is a family of obligate intracellular bacteria that infect a wide range of human and animal hosts. Chlamydia muridarum is a murine-specific species that has been leveraged as an efficacious model of disease mediated by human-s...
Staphylococcus aureus transcriptomics and single-cell sequencing approaches [0.03%]
金黄色葡萄球菌转录组和单细胞测序方法
Natalia Malachowa,Frank R DeLeo
Natalia Malachowa
Staphylococcus aureus is an important cause of human infections globally and ranks among the top causes of death by bacteria. In addition, the microbe is notorious for developing resistance to antibiotics. Methicillin-resistant S. aureus is...
Lymphotoxin beta receptor-/- mice display altered B- and T-cell subpopulations in the bone marrow and peritoneal cavity after Toxoplasma gondii infection [0.03%]
淋巴毒素β受体基因敲除小鼠感染刚地弓形虫后骨髓和腹腔B、T淋巴细胞亚群改变
Marcel Helle,Ursula R Sorg,Johannes Ptok et al.
Marcel Helle et al.
Lymphotoxin β receptor (LTβR/TNFRSF3) signaling plays a crucial role in immune defense. Notably, LTβR-deficient (LTβR-/-) mice exhibit severe defects in innate and adaptive immunity against various pathogens and succumb to Toxoplasma go...
Cell death pathways in response to Mycobacterium tuberculosis and other mycobacterial infections [0.03%]
对结核杆菌等分枝杆菌感染的细胞凋亡途径响应
Md Atik Faysal,Mostafa Hanafy,Denise K Zinniel et al.
Md Atik Faysal et al.
Cell death mechanisms play a fundamental role in mycobacterial pathogenesis. We critically reviewed 94 research manuscripts, 44 review articles, and 4 book chapters to analyze important discoveries, background literature, and potential shor...
Evaluation of Mycoplasma mycoides subsp. mycoides antigens capable of stimulating host IRG-47 release identifies Mmm604, Mmm605, and Mmm606 as potential subunit vaccine antigens [0.03%]
评估能刺激宿主IRG-47释放的Mycoplasma mycoides subsp. mycoides抗原鉴定Mmm604、Mmm605和Mmm606为潜在亚单位疫苗抗原
Tong Liu,Huanjun Zhao,Qi Wu et al.
Tong Liu et al.
Contagious bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides (Mmm), is a devastating cattle disease with high morbidity and mortality, threatening cattle productivity in Sub-Saharan Africa and potentially in parts...
Listeria monocytogenes adenosine auxotrophs are impaired for intracellular and extracellular growth but retain potent immunogenicity [0.03%]
腺苷营养缺陷型李斯特菌单核细胞增生性李斯特菌株在胞内和胞外生长受到抑制，但仍保持强大的免疫原性
Ying Feng,Mariya Lobanovska,Jenna Vickery et al.
Ying Feng et al.
Listeria monocytogenes is a facultative intracellular pathogen that has garnered attention as a potential cancer therapeutic due to its ability to induce robust cell-mediated immunity. To ensure safe clinical administration, deletion of cer...