Ian E Hollifield,Kristen L Clement,Kaylynn A Fernando et al.
Ian E Hollifield et al.
The prevailing dogma is that enterotoxigenic Escherichia coli (ETEC) use plasmid-borne colonization factors (CFs) to adhere to the intestinal epithelium, where the organisms proliferate and produce their diarrhea-causing virulence factors, ...
Guanylate-binding protein 5: a promising biomarker and therapeutic target [0.03%]
鸟苷酸结合蛋白5：有潜力的生物标志物和治疗靶点
Jianliang Lu,Wei Wang
Jianliang Lu
The guanylate-binding protein (GBP) family, a group of interferon-induced GTPases, is pivotal in pathogen defense, inflammation regulation, and tumor immunity. Among them, GBP5 has emerged as a key player due to its distinctive roles in var...
Strain-specific variation in the complement resistome of Pseudomonas aeruginosa [0.03%]
铜绿假单胞菌品系特异性补体耐受性差异
Manon Janet-Maitre,Mylène Robert-Genthon,François Cretin et al.
Manon Janet-Maitre et al.
Bloodstream infections caused by Pseudomonas aeruginosa are associated with high mortality rates. The complement system, a key component of the innate immune response, plays a major role in eliminating P. aeruginosa from human blood. Howeve...
Candida albicans gastrointestinal colonization resistance: a host-microbiome balancing act [0.03%]
白色念珠菌肠道定植抵抗：宿主-微生物组的平衡行为
Derek J Bays,Hannah P Savage
Derek J Bays
While Candida albicans is a common, commensal yeast colonizing 50%-60% of humans, it has the potential to expand in the gastrointestinal tract and enter the blood stream resulting in invasive candidiasis. Invasive candidiasis carries a mort...
Breaking down barriers: is intestinal mucus degradation by Akkermansia muciniphila beneficial or harmful? [0.03%]
突破屏障：Akkermansia muciniphila降解肠粘液是益还是害？
Anna M Tingler,Melinda A Engevik
Anna M Tingler
Akkermansia muciniphila is a specialized mucin-degrading bacterium that plays a pivotal role in gut health and disease. This review examines the dualistic nature of A. muciniphila mucin degradation, exploring its potential benefits and risk...
Yersinia pestis BipA is a novel regulator of pesticin and a type 6 secretion system [0.03%]
耶氏菌pesticin和第六型分泌系统的新型调节因子BipA
Madeleine G Scott,Wanfeng Guo,Jon S Blevins et al.
Madeleine G Scott et al.
Yersinia pestis is a gram-negative bacterium and the causative agent of bubonic, septicemic, and pneumonic plague. Y. pestis is most commonly transmitted to humans by infected fleas that deposit the bacteria into the dermis at the bite site...
Isabel Erickson,Jessica Tung,Drew J Schwartz
Isabel Erickson
Preterm infants are highly susceptible to bacterial infections and inflammatory diseases. These vulnerabilities arise from disruptions in gut microbiome structure and function, immune system immaturity, and underdeveloped organ systems. In ...
Loss of pulmonary tissue protection and neutrophil microbicidal defects promote severe Aspergillus fumigatus infection during influenza A virus infection [0.03%]
流感病毒感染期间肺泡巨噬细胞功能障碍促进曲霉菌感染加重
Zhihan Wang,Taylor Schmit,Kai Guo et al.
Zhihan Wang et al.
Invasive pulmonary aspergillosis (IPA) is a severe fungal disease caused by Aspergillus fumigatus (Af) that may spread hematogenously to extrapulmonary organs. IPA is typically associated with a broad spectrum of immunocompromised condition...
Exploring the vaginal ecosystem: insights into host-microbe interactions and microbial community dynamics [0.03%]
探索阴道生态系统：关于宿主-微生物相互作用及微环境动态的见解
Emily F Landolt,Jéssica da Conceição Mendonça,Abbey E Behler et al.
Emily F Landolt et al.
The vaginal tract is a complex environment that changes throughout various life stages. Recent advances have improved our understanding of the vaginal microbiota and the influence of host factors on microbial colonization. The vaginal niche...
Infections as ecosystems: community metabolic interactions in microbial pathogenesis [0.03%]
感染与生态系统：微生物致病中的群落代谢相互作用
Aanuoluwa E Adekoya,Shannon R West,Sydney K Arriaga et al.
Aanuoluwa E Adekoya et al.
Microbes rarely exist alone; instead, they live in dynamic multi-species communities with a range of metabolic capacities. To establish within a polymicrobial community, an organism must compete with the other members of the community for s...