Polyphosphatases have a polyphosphate-independent influence on the virulence of Cryptococcus neoformans [0.03%]
聚磷酸酶对新型隐球菌的毒力具有多磷酸盐非依赖性影响
Kabir Bhalla,Eddy Sánchez León-Hing,Yu-Hsuan Huang et al.
Kabir Bhalla et al.
Cryptococcus neoformans, an invasive basidiomycete fungal pathogen, causes one of the most prevalent, life-threatening diseases in immunocompromised individuals and accounts for ~19% of AIDS-associated deaths. Therefore, understanding the p...
Heterologous prime-boost immunization of two-component vaccine candidate PWDVax protected pigs against F18 enterotoxigenic Escherichia coli post-weaning diarrhea [0.03%]
由两组分疫苗候选物PWDVax组成的异源初免-加强免疫保护断奶后猪免受F18肠毒素大肠杆菌引起腹泻的危害
Chongyang Zhang,Siqi Li,Ipshita Upadhyay et al.
Chongyang Zhang et al.
Post-weaning diarrhea (PWD) is associated predominantly with enterotoxigenic Escherichia coli (ETEC) and continuously causes significant economic losses to swine producers worldwide. Currently, there are no effective countermeasures against...
Glucose uptake is essential for Brucella abortus growth in the extracellular space of the murine placenta [0.03%]
葡萄糖吸收对布鲁氏菌在鼠胎盘胞外空间生长至关重要
Leticia Lázaro-Antón,Thaynara Parente de Carvalho,Eric Pirillo et al.
Leticia Lázaro-Antón et al.
Brucella abortus infects the placenta of its natural bovine host, which results in abortion and transmission of infection to other cattle and to humans. While the metabolism of B. abortus during chronic infection of the mononuclear phagocyt...
Type I IFNs contribute to upregulation of PD-L1 during Chlamydia trachomatis infection [0.03%]
I型IFN促进沙眼衣原体感染期间PD-L1的高表达
Nicole V Reinhold-Larsson,Michael N Starnbach
Nicole V Reinhold-Larsson
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that if left untreated can cause reproductive harm. Failure of natural adaptive immunity results in chronic and repeat infections. In efforts to understand the failure of...
Peromyscus leucopus, Mus musculus, and humans have distinct transcriptomic responses to larval Ixodes scapularis bites [0.03%]
不同物种对幼虫黑腿鹿蜱咬伤的转录组反应各不相同： Peromyscus leucopus，Mus musculus 和人类之间的差异
Jeffrey S Bourgeois,Julie E McCarthy,Siu-Ping Turk et al.
Jeffrey S Bourgeois et al.
Ixodes scapularis ticks are an important vector for at least seven tick-borne human pathogens, including a North American Lyme disease spirochete, Borrelia burgdorferi. The ability for these ticks to survive in nature is credited, in part, ...
Sphingosine-mediated death of Pseudomonas aeruginosa involves degradation of cardiolipin by the maintenance of outer lipid asymmetry system [0.03%]
鞘氨醇介导的铜绿假单胞菌死亡涉及通过外脂不对称性系统维持心磷脂的降解
Heike Grassmé,Gregory C Wilson,Yuqing Wu et al.
Heike Grassmé et al.
Respiratory infections with multiresistant Pseudomonas aeruginosa are a major clinical problem, affecting mainly patients with pre-existing lung diseases such as cystic fibrosis (CF) or chronic obstructive pulmonary disease but also immunoc...
Borrelia miyamotoi in vivo antigenic variation demonstrated by serotype reisolations from infected mice [0.03%]
通过从感染小鼠中重新分离血清型展示的伯氏疏螺旋体miyamotoi体内抗原变异
Brittany A Armstrong,Kevin S Brandt,Robert D Gilmore
Brittany A Armstrong
Relapsing fever Borrelia (RFB) employs antigenic variation to alter its surface protein structure in response to host immune pressure. This process occurs by the single translocation of archived variable major protein (Vmp) pseudogenes into...
Helicobacter pylori CagA and Cag type IV secretion system activity have key roles in triggering gastric transcriptional and proteomic alterations [0.03%]
幽门螺旋杆菌CagA和Cag四型分泌系统在触发胃转录和蛋白质组学改变方面具有关键作用
Jennifer H B Shuman,Aung Soe Lin,Mandy D Westland et al.
Jennifer H B Shuman et al.
Colonization of the human stomach with cag pathogenicity island (PAI)-positive Helicobacter pylori strains is associated with increased gastric cancer risk compared to colonization with cag PAI-negative strains. To evaluate the contribution...
The hypervirulent Type-1/Type-17 phenotype of Cryptococcus neoformans clinical isolates is specific to A/J mice [0.03%]
Cryptococcus neoformans临床分离株的超毒型-1/型-17表型特异于A / J小鼠
Minna Ding,Katrina M Jackson,Madeline Harris-Gordon et al.
Minna Ding et al.
Cryptococcus neoformans is a fungal pathogen that causes cryptococcal meningitis in immunocompromised individuals. Both host- and pathogen-specific factors are known to affect patient outcome, and recent studies showed that strain-specific ...