Listeria monocytogenes adenosine auxotrophs are impaired for intracellular and extracellular growth but retain potent immunogenicity [0.03%]
腺苷营养缺陷型李斯特菌单核细胞增生性李斯特菌株在胞内和胞外生长受到抑制，但仍保持强大的免疫原性
Ying Feng,Mariya Lobanovska,Jenna Vickery et al.
Ying Feng et al.
Listeria monocytogenes is a facultative intracellular pathogen that has garnered attention as a potential cancer therapeutic due to its ability to induce robust cell-mediated immunity. To ensure safe clinical administration, deletion of cer...
Acquired tick resistance in Peromyscus leucopus alters Ixodes scapularis infection [0.03%]
鹿鼠获得性硬蜱叮咬耐受作用影响对鹿硬蜱感染的影响
Elis A Fisk,Cassie J Leonard,Kristin L Rosche et al.
Elis A Fisk et al.
Ticks are obligate hematophagous parasites and pathogen vectors responsible for morbidity and mortality worldwide. Ixodes scapularis is a vector for at least seven pathogens relevant to human and animal health, including the Lyme disease mi...
Timely excision of prophage Φ13 is essential for the Staphylococcus aureus infectious process [0.03%]
及时切除噬菌体Φ13对于金黄色葡萄球菌的感染过程是必不可少的
Olivier Poupel,Gérald Kenanian,Lhousseine Touqui et al.
Olivier Poupel et al.
Mobile genetic elements play an essential part in the infectious process of major pathogens, yet the role of prophage dynamics in Staphylococcus aureus pathogenesis is still not well understood. Here, we studied the impact of the Φ13 hlb-c...
Modulation of group B Streptococcus infection and vaginal cell inflammatory signaling in vitro by Lactobacillus crispatus-loaded electrospun fibers [0.03%]
负载Lactobacillus crispatus的静电纺丝纤维对体外群体B链球菌感染及阴道细胞炎性信号传导的调节作用
Nagwa El-Baz,Anthony Kyser,Mohamed Y Mahmoud et al.
Nagwa El-Baz et al.
Vaginal colonization by Streptococcus agalactiae, also known as Group B Streptococcus (GBS), is a major risk factor for ascending infections, preterm birth, and neonatal sepsis. Current GBS prevention efforts include routine GBS perinatal s...
Host-directed therapeutic targets in macrophages and their ligands against mycobacteria tuberculosis [0.03%]
针对巨噬细胞的宿主导向治疗靶点及其抗结核分枝杆菌作用机制
Jin Li,Yanmei Wang,Lei He et al.
Jin Li et al.
Although current combination regimens of antibiotics have significantly improved tuberculosis (TB) cure rates, substantial challenges persist in the global effort to end TB. These include poor patient compliance, the emergence of drug-resis...
Mouse monoclonal antibodies against Clostridioides difficile toxins TcdA and TcdB target diverse epitopes for neutralization [0.03%]
针对难辨梭菌毒素TcdA和TcdB的鼠单克隆抗体靶向中和不同表位
Heather K Kroh,Jaime L Jensen,Sabine Wellnitz et al.
Heather K Kroh et al.
Clostridioides difficile is a spore-forming, Gram-positive bacterium that can cause infections in subjects with weakened immune system or following antibiotic treatment. These infections may lead to pseudomembranous colitis and antibiotic-a...
Genetic transformation of Gardnerella species and characterization of vaginolysin and sialidase mutants [0.03%]
加德纳菌的基因转化及其阴道溶解素和神经氨酸酶突变株的表征
Amy K Klimowicz,Erin M Garcia,Kimberly K Jefferson et al.
Amy K Klimowicz et al.
Bacterial vaginosis (BV) is the most prevalent vaginal disorder in women of childbearing age and causes pregnancy complications, including preterm birth, amnionitis, and postpartum endometritis. BV also interferes with sexual health and inc...
The host calcium system contributes to intracellular Rickettsia pathogenesis [0.03%]
宿主钙系统对立克次体胞内致病性的作用
Jinyi C Zhu,Jack H Cook,Mustapha Dahmani et al.
Jinyi C Zhu et al.
Bacteria in the genus Rickettsia are obligate intracellular parasites of the eukaryotic cytoplasm. Pathogenic Rickettsia species are exquisitely evolved to only proliferate within eukaryotic host cells, particularly within endothelial cells...
Peter Østrup Jensen,Morten Rybtke,Tim Tolker-Nielsen
Peter Østrup Jensen
Chronic infections involving bacterial biofilms are a major clinical challenge due to the ability of biofilm to resist antimicrobial treatments and host immune responses. The resulting persistent infections are often accompanied by collater...
Cervicovaginal microbial features predict Chlamydia trachomatis spread to the upper genital tract of infected women [0.03%]
宫颈阴道微生物组特征预测感染女性沙眼衣原体向生殖道上行性传播
Sangmi Jeong,Tammy Tollison,Hayden Brochu et al.
Sangmi Jeong et al.
Chlamydia trachomatis (CT) infection can lead to pelvic inflammatory disease, infertility, and other reproductive sequelae when it ascends to the upper genital tract. Factors including chlamydial burden, coinfection with other sexually tran...