Protein tyrosine phosphatase PTP1B is a positive regulator of the intracellular development of Chlamydia trachomatis [0.03%]
蛋白酪氨酸磷酸酶PTP1B是沙眼衣原体细胞内发育的正调节因子
M Soban Khan,Rom Peles,Anna Haralampiev et al.
M Soban Khan et al.
The intracellular survival and replication of Chlamydia trachomatis rely on the precise manipulation of host signaling pathways. Host kinases are instrumental in the modulation of host signaling during C. trachomatis infection. However, the...
TRP75-mediated STAT3 activation promotes anti-apoptotic signaling and Ehrlichia chaffeensis infection [0.03%]
TRP75介导的STAT3活化促进抗凋亡信号传导和安氏伊立利亚体感染
Nicholas A Pittner,Jaclyn R McCoy,Duc-Cuong Bui et al.
Nicholas A Pittner et al.
Ehrlichia chaffeensis is an obligately intracellular bacterium that manipulates mononuclear phagocytes by hijacking host cell signaling pathways to promote infection. Previous studies from our laboratory have shown that multiple signal tran...
Dual immunomodulatory and antileishmanial potential of TLR7/8 agonists against Leishmania donovani [0.03%]
TLR7/8激动剂针对利什曼原虫的双重免疫调节和抗立克次氏体潜力
Shivani Thakur,Deepender Kaushik,Kushvinder Kumar et al.
Shivani Thakur et al.
Visceral leishmaniasis (VL), caused by Leishmania donovani, is a neglected tropical disease with limited therapeutic options and increasing drug resistance. This study investigates the immunological mechanisms and antiparasitic efficacy of ...
METTL3 aggravates lung injury in neonatal mice with Streptococcus pneumoniae-induced pneumonia via the circ_0001239/KLF10 axis [0.03%]
METTL3通过circ_0001239/KLF10轴加重肺炎球菌引起的新生小鼠肺损伤
Liping Yang,Yufei Xie,Panpan Yan et al.
Liping Yang et al.
As a leading causative agent of pneumonia infection worldwide, Streptococcus pneumoniae (Spn) induces lung injury and presents substantial therapeutic challenges. To elucidate the role of methyltransferase-like 3 (METTL3) in modulating circ...
Kat Pick,Valeria Tsviklist,Lauren Stadel et al.
Kat Pick et al.
Here, we report the identification of bacteriophage Mu contamination in a commonly used Citrobacter rodentium DBS100 ∆cpxRA mutant strain. After re-constructing a new Mu-free ∆cpxRA strain, we independently replicated the results of a rec...
Alterations in nutrient availability in the lungs during Streptococcus pneumoniae-induced pneumonia [0.03%]
肺炎链球菌诱导的肺炎期间肺营养物质可用性的改变
Hansol Im,Vipin Chembilikandy,Adonis D&#x;Mello et al.
Hansol Im et al.
Streptococcus pneumoniae is a leading cause of pneumonia. Importantly, the extent and impact of changes in the infected airway on bacterial nutrient availability and gene expression are not known. Utilizing untargeted UPLC-ESI-MS/MS metabol...
Longlong Wang,Jijie Jiang,Mengke Hou et al.
Longlong Wang et al.
Mycobacterium marinum serves as an ideal model organism for studying tuberculosis due to its genetic similarity to Mycobacterium tuberculosis. However, there is a need for more suitable animal models to study M. marinum infections. In this ...
Induced necroptosis limits Toxoplasma gondii replication in a RIPK3/MLKL-dependent manner [0.03%]
RIPK3/MLKL依赖的诱导性坏死凋亡限制弓形虫增殖
Billy J Erazo,Laura J Knoll
Billy J Erazo
Toxoplasma gondii is an obligate intracellular parasite capable of subverting host defenses to establish infection. Necroptosis, a lytic pro-inflammatory form of programed cell death, has emerged as a host defense mechanism against intracel...
The emerging view on the roles of butyrate in Clostridioides difficile pathogenesis [0.03%]
丁酸在艰难梭菌致病机制中的作用的最新研究进展
Horia A Dobrila,Andrew J Hryckowian
Horia A Dobrila
The Centers for Disease Control and Prevention classifies Clostridioides difficile as an urgent threat to the nation's health, as it causes 450,000 infections, 15,000 deaths, and 1 billion dollars in excess healthcare costs per year in the ...
Long non-coding RNA U90926 modulates IFN-γ-stimulated gene transcription and cell-intrinsic anti- Cryptosporidium defense in intestinal epithelial cells [0.03%]
长链非编码RNA U90926调节肠上皮细胞中IFN-γ刺激的基因转录和固有抗隐孢子虫防御功能
Marion L Graham,Ai-Yu Gong,Kehua Jin et al.
Marion L Graham et al.
Cryptosporidium infects the intestine in a wide variety of vertebrates, and intestinal epithelial cells provide the first line of defense against Cryptosporidium infection. Interferon gamma (IFN-γ) from immune cells infiltrated at the site...